Abstract: It is an object of the present invention to provide a safe hair dye, which has a good dyeing property and is easy-to-use, and which has less uneven dyeing and has high stability of the formulation. The present invention provides a hair dye which comprises a combination of (1) a first gel agent containing tannic acid, benzyl alcohol and xanthane gum, and (2) a second agent containing an iron salt.

Abstract: Provided is a hair dye, which comprises a combination of (1) a first agent containing a substance reacting with iron to develop color, and (2) a second agent containing (a) an iron salt and (b) at least one component selected from among xylitol, sorbitol, pentylene glycol, dipropylene glycol, triethylene glycol, erythritol and diglycerin.

Abstract: It is an object of the present invention to provide a safe hair dye, which has a good dyeing property and is easy-to-use, and which has less uneven dyeing and has high stability of the formulation. The present invention provides a hair dye which comprises a combination of (1) a first gel agent containing tannic acid, benzyl alcohol and xanthane gum, and (2) a second agent containing an iron salt.

Abstract: Provided is a hair dye, which comprises a combination of (1) a first agent containing a substance reacting with iron to develop color, and (2) a second agent containing (a) an iron salt and (b) at least one component selected from among xylitol, sorbitol, pentylene glycol, dipropylene glycol, triethylene glycol, erythritol and diglycerin.

Abstract: It is an object of the present invention to provide a safe hair dye, which requires a short hair dyeing time, has good hair dyeing property and color tone, and also has an effect of preventing photofading. The present invention provides a hair dye, which comprises a combination of (a) a first agent containing a substance reacting with iron to develop color and an ultraviolet absorbent having a 2-hydroxybenzophenone skeleton, and (b) a second agent containing iron salt.

Abstract: It is an object of the present invention to provide a composition for hair which comprises highly safe nanoparticles having high transparency due to the small particle size and high permeability into hair and scalp. The present invention provides a composition for hair which comprises protein nanoparticles containing an active ingredient for hair.

Abstract: It is an object of the present invention to provide a method for producing a hair cosmetic product comprising protein nanoparticles which is obtained by mixing an aqueous medium and an oil medium, wherein the method enables stable emulsification without losing the performance of the protein nanoparticles. The present invention provides a method for producing a hair cosmetic product containing protein nanoparticles which is obtained by mixing an aqueous medium and an oil medium, wherein (a) protein nanoparticles having a mean particle size of 10 to 200 nm are mixed with an aqueous medium having a pH value different from the isoelectric point of the protein at an amount of 0.01% by weight to 5% by weight based on the total weight of the entire solution; and (b) the obtained liquid is mixed with a substance selected from a cationic substance and an anionic substance, which has an electric charge that is on the same side as that of the protein obtained in the step (a).

Abstract: It is an object of the present invention to provide a safe hair dye, which requires a short hair dyeing time, has good hair dyeing property and color tone, and also has an effect of preventing photofading. The present invention provides a hair dye, which comprises a combination of (a) a first agent containing a substance reacting with iron to develop color and an ultraviolet absorbent having a 2-hydroxybenzophenone skeleton, and (b) a second agent containing iron salt.

Abstract: It is an object of the present invention to provide a composition for hair which comprises highly safe nanoparticles having high transparency due to the small particle size and high permeability into hair and scalp. The present invention provides a composition for hair which comprises protein nanoparticles containing an active ingredient for hair.

Abstract: It is an object of the present invention to provide a skin anti-aging agent for external use which comprises highly safe protein nanoparticles having high transparency due to the small particle size and high permeability into skin. The present invention provides a skin anti-aging agent for external use, which comprises protein nanoparticles containing an active ingredient.

Abstract: An object of the present invention is to provide highly safe nanoparticles which can be used simultaneously for imaging, hyperthermia and DDS and have high drug incorporation ratio. The present invention provides a nanoparticle which comprises an inorganic nanoparticle of 1 to 500 nm in average particle size having an active substance immobilized on the surface and a polymer.

Abstract: An object of the present invention is to provide nanoparticles that can easily be delivered to a small site such as a capillary and can be produced using highly biocompatible and safe material. The present invention provides a nanoparticle which contains at least one pharmaceutically active component, a magnetically responsive particle, and a protein.

Abstract: An object of the present invention to provide: a nanoparticle, which can be produced without the use of surfactants and synthetic polymers, which has a controllable size and is stable in the acidic range, and which further contains an active substance; and a method for producing the same. The present invention provides a casein nanoparticle which contains an active substance and has an average particle size between 10 nm or more and less than 300 nm, which is produced by the following steps (a) to (c): (a) a step of mixing casein into a basic aqueous medium between pH 8 or more and less than pH 11; (b) a step of adding at least one type of active substance to the solution obtained in the step (a); and (c) a step of injecting the solution obtained in the step (b) into an acidic aqueous medium at pH 3.5 to pH 7.5.

Abstract: It is an object of the present invention to provide a highly safe composition comprising minoxidil and having high transparency due to the small particle size and high permeability into scalp and hair follicles. The present invention provides a protein nanoparticle which comprises minoxidil.

Abstract: It is an object of the present invention to provide a skin anti-aging agent for external use which comprises highly safe protein nanoparticles having high transparency due to the small particle size and high permeability into skin. The present invention provides a skin anti-aging agent for external use, which comprises protein nanoparticles containing an active ingredient.

Abstract: A hair dye composition containing an azo dye (1) or a salt thereof: wherein R represents a coupler moiety, R1 and R3 each independently represent —SO3M, —SO2NR4R5 or a hydrogen atom, R2, R4 and R5 each independently represent a hydrogen atom or a substituent, and M represents a hydrogen atom, metal atom or ammonium, with a proviso that R1 and R3 are not hydrogen atoms at the same time.

Abstract: It is an object of the present invention to provide highly safe nanoparticles made from highly biocompatible materials without the use of a surfactant or synthetic polymer. The present invention provides a protein nanoparticle which is obtained by enzymatic crosslinking during and/or after the formation of protein nanoparticle.

Abstract: It is an object of the present invention to provide an anti-acne skin agent for external use which comprises highly safe protein nanoparticles having high transparency due to the small particle size, moisturizing properties, and high permeability into skin. The present invention provides an anti-acne skin agent for external use, which comprises protein nanoparticles containing an active ingredient.

Abstract: An object of the present invention is to provide an external dermatologic preparation which comprises nanoparticles consisting of proteins that can exhibit desirable effects via regulation of particle diameters. The present invention provides an external dermatologic preparation which comprises protein nanoparticles containing an active ingredient and having an average particle size of 200 to 500 nm.

Abstract: It is an object of the present invention to provide a transpulmonary preparation wherein physiologically active ingredient can be stably retained and which has high absorption efficacy and gives low damage to tissue. The present invention provides a transpulmonary preparation which comprises protein nanoparticles containing an active ingredient and having an average particle size of 200 nm to 500 nm.