Patents by Inventor Makiko Nagai

Makiko Nagai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stem cell-based culture system for drug development
    Patent number: 9765297
    Abstract: The present invention relates to culture systems comprising differentiated stem cells, that may be used for identifying agents useful in treating degenerative nervous system disorders and are suitable for high-throughput screening applications. It is based, at least in part, on the discovery that co-cultures of (i) astrocytes expressing a mutated SODI gene and (ii) stem-cell derived motor neurons manifested cell death via a Bax-dependent mechanism, and modeled motor neuron death in amyotrophic lateral sclerosis.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: September 19, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Serge Przedborski, Hynek Wichterle, Makiko Nagai, Thomas M. Jessell
  • STEM CELL-BASED CULTURE SYSTEM FOR DRUG DEVELOPMENT
    Publication number: 20100267073
    Abstract: The present invention relates to culture systems comprising differentiated stem cells, that may be used for identifying agents useful in treating degenerative nervous system disorders and are suitable for high-throughput screening applications. It is based, at least in part, on the discovery that co-cultures of (i) astrocytes expressing a mutated SODI gene and (ii) stem-cell derived motor neurons manifested cell death via a Bax-dependent mechanism, and modeled motor neuron death in amyotrophic lateral sclerosis.
    Type: Application
    Filed: April 10, 2008
    Publication date: October 21, 2010
    Inventors: Serge Przedborski, Hynek Wichterle, Makiko Nagai, Thomas M. Jessell