Patents by Inventor Makiko OTANI

Makiko OTANI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230021481
    Abstract: An object of the present invention is to provide a standard substance for quantification of PSA having a specific sugar chain that can be used in a general purpose quantification, wherein the standard substance has less unbalanced sugar chain expression patterns, can be manufactured with high reproducibility, and enables the quantification of patient's sample comprising a high concentration of PSA, and preparation method therefor, standard solution for PSA quantification, and PSA quantification method. The standard substance comprises a compound having the structure of a PSA with a sugar chain represented by any of the following formulae A to D, and is isolated and purified from a natural product, chemically or enzymatically altered from a natural product, or the compound is artificially synthesized.
    Type: Application
    Filed: November 10, 2020
    Publication date: January 26, 2023
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Tomonori KANEKO, Takatoshi KAYA, Makiko OTANI
  • Patent number: 11549940
    Abstract: A method for detecting an analyte according to the present invention includes: a first step of supplying a specimen to a detection device having a first ligand that is immobilized on a substrate and is capable of specifically binding to the analyte, the specimen being supplied onto the substrate of the detection device, and then causing the analyte included in the specimen to bind to the first ligand; a second step of supplying, onto the substrate, a second ligand that is labeled with a marker and is capable of specifically binding to the analyte, and then causing the second ligand to bind to the analyte bound to the first ligand; and a third step of measuring the second ligand bound to the analyte, wherein in the second step, carboxymethyl dextran is supplied onto the substrate.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: January 10, 2023
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Makiko Otani, Koji Miyazaki
  • Patent number: 11169089
    Abstract: A measurement chip including a prism, a metal film, and a capturing body is prepared. In a state in which a specimen is present on the metal film, scattered light obtained when first light which passes through the metal film and the specimen is scattered in the specimen when the first light is applied to the metal film from a prism side at a first incident angle smaller than a critical angle is detected. In a state in which a substance to be measured is captured by the capturing body and the specimen is not present on the metal film, a signal indicating an amount of the substance to be measured generated in the measurement chip when second light is applied to the metal film at a second incident angle not smaller than the critical angle from the prism side is detected. On the basis of a hematocrit value of the specimen determined from a light amount of the scattered light, a measurement value indicating the amount of the substance to be measured determined from the signal is corrected.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: November 9, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Tetsuya Noda, Fumio Nagai, Youichi Aoki, Makiko Otani
  • Publication number: 20210285874
    Abstract: A measurement chip including a prism, a metal film, and a capturing body is prepared. In a state in which a specimen is present on the metal film, scattered light obtained when first light which passes through the metal film and the specimen is scattered in the specimen when the first light is applied to the metal film from a prism side at a first incident angle smaller than a critical angle is detected. In a state in which a substance to be measured is captured by the capturing body and the specimen is not present on the metal film, a signal indicating an amount of the substance to be measured generated in the measurement chip when second light is applied to the metal film at a second incident angle not smaller than the critical angle from the prism side is detected. On the basis of a hematocrit value of the specimen determined from a light amount of the scattered light, a measurement value indicating the amount of the substance to be measured determined from the signal is corrected.
    Type: Application
    Filed: September 6, 2017
    Publication date: September 16, 2021
    Inventors: Tetsuya NODA, Fumio NAGAI, Youichi AOKI, Makiko OTANI
  • Publication number: 20200408688
    Abstract: An object of the present invention is to provide: a labeled antibody dispersion liquid in which a labeled antibody having a label substance bonded to an antibody is dispersed favorably when the labeled antibody is used in measurement; and a kit for SPFS. A labeled antibody dispersion liquid contains a labeled antibody having a label substance bonded to a thiol group generated by cleaving some of disulfide bonds of an antibody molecule; and a non-ionic surfactant.
    Type: Application
    Filed: March 22, 2019
    Publication date: December 31, 2020
    Inventors: Makiko OTANI, Takanori MURAYAMA
  • Publication number: 20200256844
    Abstract: To provide an inspection cartridge capable of preventing a user from using a blood sample of a wrong vacuum blood collection tube when the user dispenses the blood sample from the vacuum blood collection tube to the inspection cartridge, and a blood inspection device which performs a blood inspection using the same. An inspection cartridge used for performing a blood inspection with a blood inspection device provided with an identifier for identifying an anticoagulant usable in the inspection cartridge.
    Type: Application
    Filed: December 4, 2017
    Publication date: August 13, 2020
    Inventors: Masanao MAJIMA, Makiko OTANI, Masataka MATSUO, Takanori MURAYAMA
  • Publication number: 20200249226
    Abstract: A method for detecting an analyte according to the present invention includes: a first step of supplying a specimen to a detection device having a first ligand that is immobilized on a substrate and is capable of specifically binding to the analyte, the specimen being supplied onto the substrate of the detection device, and then causing the analyte included in the specimen to bind to the first ligand; a second step of supplying, onto the substrate, a second ligand that is labeled with a marker and is capable of specifically binding to the analyte, and then causing the second ligand to bind to the analyte bound to the first ligand; and a third step of measuring the second ligand bound to the analyte, wherein in the second step, carboxymethyl dextran is supplied onto the substrate.
    Type: Application
    Filed: October 2, 2018
    Publication date: August 6, 2020
    Inventors: Makiko OTANI, Koji MIYAZAKI
  • Publication number: 20190187125
    Abstract: A specimen containing blood is divided into a first specimen and a second specimen. The blood in the second specimen is hemolyzed. The first specimen containing a substance to be measured is introduced into an accommodating unit and a measurement value indicating an amount of the substance to be measured in the first specimen in a state in which the blood is not hemolyzed is acquired. In a state in which the second specimen in a state in which the blood is hemolyzed is present in the accommodating unit of a measurement chip, second light acquired when first light including light of a wavelength absorbed by a red blood cell passes through the second specimen in the accommodating unit is detected. On the basis of a detection result of the second light, a hematocrit value of the specimen is determined. The measurement value is corrected on the basis of the hematocrit value.
    Type: Application
    Filed: August 9, 2017
    Publication date: June 20, 2019
    Inventors: Makiko OTANI, Tetsuya NODA, Fumio NAGAI