Abstract: A method for manufacturing a fluidic device comprises: forming a laminate including a first substrate made from resin material transmissive to laser light, an intermediate layer stacked on the first substrate and made from resin material absorptive to the laser light, and a second substrate stacked on the intermediate layer and made from resin material transmissive to the laser light; and welding the first substrate and the intermediate layer, and the intermediate layer and the second substrate, by irradiating the laminate with laser light from the direction of the first or the second substrate and melting the intermediate layer over the entire thickness direction in an area irradiated with the laser light, wherein the forming includes forming a flow channel in a contact surface of the first or the second substrate with the intermediate layer; or forming a penetration area penetrating in the stacked direction in the intermediate layer.

Abstract: An imaging device (10) includes a substrate (1), a first optical system (2), and an imaging part (3). A subject (110) is disposed on the substrate (1). The first optical system (2) irradiates the subject (110) with first emitted light (L1). The imaging part (3) images an interference image between first reflected light (L2) and second reflected light (L3). The first reflected light (L2) is the first emitted light (L1) reflected at a first interface (F1) conforming to an outer surface of the subject (110). The second reflected light (L3) is the first emitted light (L1) reflected at a second interface (F2) between the subject (110) and the substrate (1).

Abstract: In a first aspect of the present invention, a manipulation method of an organism is provided which includes: forming a gas-liquid interface, in which a restoring force acts against minute interface movement, in a flow channel or at an end part of the flow channel, with the end part immersed in a liquid in which an organism is immersed; and manipulating the organism by using the gas-liquid interface.

Abstract: An analysis system includes: an acquisition unit configured to acquire a cell image including images of a plurality of cultured cells which are cultured in a medium; and an image analyzing unit configured to analyze living states of the plurality of cultured cells included in the cell image on the basis of luminance values and cell diameters of the cultured cells included in the cell image.

Abstract: According to a first aspect of the present invention, a method of applying a force to an organism is provided which includes: forming a gas-liquid interface between a liquid, in which an organism is immersed, and a gas in a flow channel or at an end portion of the flow channel after arranging the end portion in the liquid; controlling a vector of a force applied from the gas-liquid interface to the organism; and applying a force to the organism from the gas-liquid interface.

Abstract: A first aspect of the present invention provides a manipulating method of an organism including forming an air bubble in liquid where the organism is immersed, attaching the organism to the air bubble, and controlling an airflow by generating the airflow in the air bubble and manipulating a position of the organism with the airflow.

Abstract: In a first aspect of the present invention, a manipulation method of an organism is provided, comprising: forming an air bubble by introducing gas into liquid in which an organism is submerged; controlling of energy before, during or after the forming of the air bubble, including controlling of difference (E1 - E2) obtained by subtracting, from surface free energy E1 at an interface between the gas and the organism, surface free energy E2 at an interface between the gas and the liquid; and manipulating the organism using the air bubble, by bringing the air bubble into contact with the organism during or after the controlling of energy.

Abstract: A determination device is provided which includes a determination unit which refers to a learned model generated by learning a teacher data including an optical spectrum measured from a cancer tissue whose primary focus is known, and determines a primary focus of a biological specimen according to input data based on an optical spectrum of a biological specimen measured by a measurement unit.