Patents by Inventor Makiko Yui

Makiko Yui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for expanding hematopoietic stem cells using heterocyclic compound
    Patent number: 9527828
    Abstract: An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various hematopoietic disorders is provided. A method for expanding hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises culturing hematopoietic stem cells and/or hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein X, Y, X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
    Type: Grant
    Filed: December 6, 2008
    Date of Patent: December 27, 2016
    Assignees: Nissan Chemical Industries, Ltd., ReproCELL Incorporated
    Inventors: Taito Nishino, Norihisa Ishiwata, Katsuaki Miyaji, Shunsuke Iwamoto, Yasuyuki Asai, Makiko Yui
  • Method for producing hematopoietic stem cells using pyrazole compounds
    Patent number: 9212348
    Abstract: An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided. A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R1 to R8 are as defined in the description).
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: December 15, 2015
    Assignees: NISSAN CHEMICAL INDUSTRIES, LTD., REPROCELL INCORPORATED
    Inventors: Taito Nishino, Makiko Yui, Yasuyuki Asai, Ayako Asai
  • METHOD FOR PRODUCING HEMATOPOIETIC STEM CELLS USING PYRAZOLE COMPOUNDS
    Publication number: 20140057353
    Abstract: An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided. A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R1 to R8 are as defined in the description).
    Type: Application
    Filed: December 1, 2011
    Publication date: February 27, 2014
    Applicants: REPROCELL INCORPORATED, NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Ayako Asai, Taito Nishino, Makiko Yui
  • METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND
    Publication number: 20100266556
    Abstract: An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various hematopoietic disorders is provided. A method for expanding hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises culturing hematopoietic stem cells and/or hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein X, Y, X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
    Type: Application
    Filed: December 6, 2008
    Publication date: October 21, 2010
    Applicants: Nissan Chemical Industries Ltd., ReproCell Incorporated
    Inventors: Taito Nishino, Norihisa Ishiwata, Katsuaki Miyaji, Shunsuke Iwamoto, Yasuyuki Asai, Makiko Yui