Abstract: A light emitting element of one or more embodiments includes a first electrode, a second electrode oppositely to the first electrode, and an emission layer between the first electrode and the second electrode. The light emitting element of one or more embodiments includes a polycyclic compound represented by a specific chemical structure in the emission layer, thereby showing improved emission efficiency and life characteristics.

Abstract: A DC/DC converter in which a both-end voltage of each of capacitors can be safely uniformalized while an over current, which is passed through between the capacitors composing the DC/DC converter, is prevented. In a DC/DC converter which includes a plurality of switching elements, a reactor, a low-voltage side capacitor, a high-voltage side capacitor, a charge-discharge capacitor, and a controller which drives and controls the switching elements, the controller performs soft start control in which a duty ratio of at least one of the switching elements is gradually varied from 0% to 100%, and the switching element, in which the soft start control is not performed during the term of the soft start control, is turned off.

Abstract: A DC/DC converter in which a both-end voltage of each of capacitors can be safely uniformalized while an over current, which is passed through between the capacitors composing the DC/DC converter, is prevented. In a DC/DC converter which includes a plurality of switching elements, a reactor, a low-voltage side capacitor, a high-voltage side capacitor, a charge-discharge capacitor, and a controller which drives and controls the switching elements, the controller performs soft start control in which a duty ratio of at least one of the switching elements is gradually varied from 0% to 100%, and the switching element, in which the soft start control is not performed during the term of the soft start control, is turned off.

Abstract: Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.

Abstract: There is provided an FGF2 substitute-containing medicinal composition which comprises, as an active ingredient, a chimeric protein comprising the amino acid sequence of an FGF1 protein in which a partial sequence including a sequence of at least positions 62-83 within a sequence of positions 41-83 is substituted with a partial sequence at the corresponding positions in the amino acid sequence of an FGF2 protein; and the remaining region is formed of the amino acid sequence of FGF1. In particular, this medicinal composition is used for wound healing and for the prevention and treatment of radiation-induced damage, and it exhibits a pharmacological action superior to that of an FGF2 medicinal composition, and further, it can be easily formulated into a preparation.

Abstract: An object of the present invention is to clarify unelucidated aspects in the control mechanism of circadian rhythms. The present inventors have newly found that ROR? (retinoic acid binding-receptor alpha; the same shall apply hereinafter) stimulates an induction of Bmal1 expression and also that the induction of Bmal1 expression is promoted under hypoxia. These findings strongly suggest the existence of a control mechanism of circadian rhythms that, when ROR? expression is promoted under hypoxia or the like, an induction of Bmal1 expression is stimulated and, when the induction of Bmal1 expression is stimulated, binding between BMAL1 and CLOCK is stimulated and an induction of Per gene or Cry gene expression is stimulated. The present invention, therefore, has applicability as jet-lag regulating agents and anticancer agents.

Abstract: There is provided a method that achieves the prediction of a biological rhythm with high precision while minimizing the number of times a biological specimen is collected from a subject. There is also provided a method for predicting a biological rhythm of a subject on the basis of time series expression level data obtained by measuring expression levels of two clock genes in biological specimens collected from the subject three times within 24 hours, the clock genes having different phases of circadian cycles of a change in expression levels. In this method for predicting a biological rhythm, a biological rhythm can be predicted with particularly high precision by collecting a biological specimen from a subject three times within 24 hours at eight-hour intervals.

Abstract: There is provided an FGF2 substitute containing medicinal composition which comprises, as an active ingredient, a chimeric protein comprising the amino acid sequence of an FGF1 protein in which a partial sequence including a sequence of at least positions 62-83 within a sequence of positions 41-83 is substituted with a partial sequence at the corresponding positions in the amino acid sequence of an FGF2 protein; and the remaining region is formed of the amino acid sequence of FGF1. In particular, this medicinal composition is used for wound healing and for the prevention and treatment of radiation-induced damage, and it exhibits a pharmacological action superior to that of an FGF2 medicinal composition, and further, it can be easily formulated into a preparation.

Abstract: To provide a simple and low-invasive method for obtaining information on a biorhythm of an individual organism. Provided is a method for obtaining information on a biorhythm of an individual organism based on variations over time in an expression level of a clock gene in a hair follicle cell of the individual organism. According to this method, a phase shift of the biorhythm of the individual organism can be detected by preparing a plurality of times about the individual organism and conducting a collation. Further, a phase shift of the biorhythm of the individual organism can also be detected by collating an expression level of the clock gene at a predetermined time with the molecular clock table.

Abstract: Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.

Abstract: An object of the present invention is to clarify unelucidated aspects in the control mechanism of circadian rhythms. The present inventors have newly found that ROR? (retinoic acid binding-receptor alpha; the same shall apply hereinafter) stimulates an induction of Bmal1 expression and also that the induction of Bmal1 expression is promoted under hypoxia. These findings strongly suggest the existence of a control mechanism of circadian rhythms that, when ROR? expression is promoted under hypoxia or the like, an induction of Bmal1 expression is stimulated and, when the induction of Bmal1 expression is stimulated, binding between BMAL1 and CLOCK is stimulated and an induction of Per gene or Cry gene expression is stimulated. The present invention, therefore, has applicability as jet-lag regulating agents and anticancer agents.

Abstract: A device for detecting the degree of deterioration of bank notes has a driving rotary body and a detection rotary body, which are a pair of oppositely disposed rollers each having alternately disposed enlarged diameter portions and annular grooves. These enlarged portions and the grooves of the two rotary bodies are in staggered, opposed relationship so that when a bank note is conveyed between the two rotary bodies, the note is deformed into a wave shape. The rotation of the driving rotary body influences the rotary movement of the detection rotary body depending on the stiffness of the bank note in the wave shape. When the bank note is new and stiff, the influence is strong, while when the bank note is old and deteriorated with a small stiffness, the influence is small. Such influence is detected from variation in rotary movement of the detection rotary body to which a predetermined rotational characteristic is given by a resistance imparting device.