Patents by Inventor Makoto Haino

Makoto Haino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-hydroxyformamide derivative and medicament containing same
    Patent number: 8765814
    Abstract: A compound represented by the following general formula (I) which has ADAM17 inhibitory activity, or a salt thereof, or a solvate thereof: wherein X represents a phenylene group; Y represents a hydrogen atom, —(CH2)mR1 or the like; R1 represents —NR5COR2, —NR5SO2R2 or —NR3R4; R2 represents a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group; R3 and R4 represent a C1-C6 alkyl group and the like; R5 represents a hydrogen atom or a C1-C6 alkyl group or the like; m indicates an integer of from 0 to 4; and Z represents a hydrogen atom or a C1-C6 alkyl group.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: July 1, 2014
    Assignee: Kaken Pharmaceutical Co., Ltd.
    Inventors: Kentaro Kawai, Shigeru Miyamoto, Masanao Shimano, Makoto Haino
  • N-HYDROXYFORMAMIDE DERIVATIVE AND MEDICAMENT CONTAINING SAME
    Publication number: 20130131180
    Abstract: A compound represented by the following general formula (I) which has ADAM17 inhibitory activity, or a salt thereof, or a solvate thereof: wherein X represents a phenylene group; Y represents a hydrogen atom, —(CH2)mR1 or the like; R1 represents —NR5COR2, —NR5SO2R2 or —NR3R4; R2 represents a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group; R3 and R4 represent a C1-C6 alkyl group and the like; R5 represents a hydrogen atom or a C1-C6 alkyl group or the like; m indicates an integer of from 0 to 4; and Z represents a hydrogen atom or a C1-C6 alkyl group.
    Type: Application
    Filed: July 5, 2011
    Publication date: May 23, 2013
    Applicant: KAKEN PHARMACEUTICAL CO., LTD.
    Inventors: Kentaro Kawai, Shigeru Miyamoto, Masanao Shimano, Makoto Haino
  • Reverse hydroxamic acid derivatives
    Patent number: 7511144
    Abstract: Reverse hydroxamic acid derivatives having specific structure represented by a general formula (Ia): (wherein A is a hydrogen atom or the like; Ar1 is an arylene or the like; Ar2 is an optionally substituted aryl, a heteroaryl or the like; R1 is a hydrogen atom, an alkyl or the like; R2a is a substituted cycloaryl, a heterocycloaryl or the like) and a general formula (I): (wherein A, Ar1, Ar2, and R1 are the same as defined above and R2 is an hydrogen atom, R2a or the like) and salts thereof, which have TNF-? converting enzyme (TACE) inhibitory activity.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: March 31, 2009
    Assignee: Kaken Pharmaceutical Co., Ltd.
    Inventors: Masanao Shimano, Noriyuki Kamei, Tomohiro Tanaka, Tatsuhiro Harada, Makoto Haino, Akihiko Okuyama, Yoshio Arakawa, Yoshiko Murakami
  • Reverse hydroxamic acid derivatives
    Publication number: 20040242928
    Abstract: Reverse hydroxamic acid derivatives having specific structure represented by a general formula (Ia): 1
    Type: Application
    Filed: March 4, 2004
    Publication date: December 2, 2004
    Inventors: Masanao Shimano, Noriyuki Kamei, Tomohiro Tanaka, Tatsuhiro Harada, Makoto Haino, Akihiko Okuyama, Yoshio Arakawa, Yoshiko Murakami