Patents by Inventor Makoto HARUMOTO

Makoto HARUMOTO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIQUID EMBOLICS
    Publication number: 20210290816
    Abstract: Described herein are formulations that transition from a liquid state to a solid state for use in the embolization of arteriovenous malformations (AVM's) and solid tumors.
    Type: Application
    Filed: March 17, 2021
    Publication date: September 23, 2021
    Inventors: Matthew Fitz, Gregory M. Cruise, Makoto Harumoto, Yue Wu
  • PARTICLES
    Publication number: 20200368171
    Abstract: Described are particles configured for intravascular delivery of pharmaceutical agents to a diseased site.
    Type: Application
    Filed: May 22, 2020
    Publication date: November 26, 2020
    Inventors: Makoto Harumoto, Gregory M. Cruise, Michael Kebede
  • Long-lasting, controlled-release local anesthetic liposome preparation
    Patent number: 9724300
    Abstract: A long-lasting, controlled-release local anesthetic liposome preparation is produced by: providing a liposome composition, which is obtained by mixing, in a water-miscible organic solvent, a first aqueous phase solution with a water-miscible organic solution, in which a phospholipid and cholesterol are contained at a defined total concentration, at a defined ratio by volume thereby obtaining an emulsion wherein a total concentration of the phospholipid and cholesterol in the mixed phase is at 15 w/v % to 50 w/v %, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution to obtain a liposome composition wherein an ion gradient is formed between an internal-region aqueous phase of a liposome membrane made of the first aqueous phase solution and an external-region aqueous phase of the liposome membrane made of the second aqueous phase solution; and encapsulating a local anesthetic in the internal-region aqueous phase according to a remote loading method.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: August 8, 2017
    Assignees: TERUMO KABUSHIKI KAISHA, KANSAI MEDICAL UNIVERSITY EDUCATIONAL CORPORATION
    Inventors: Keiko Yamashita, Yasuo Kurosaki, Makoto Harumoto, Kyoko Shimamura, Masaki Kaibori, Yoshiro Araki, Masanori Kon, Seiji Ito
  • LONG-LASTING, CONTROLLED-RELEASE LOCAL ANESTHETIC LIPOSOME PREPARATION
    Publication number: 20150250724
    Abstract: A long-lasting, controlled-release local anesthetic liposome preparation is produced by: providing a liposome composition, which is obtained by mixing, in a water-miscible organic solvent, a first aqueous phase solution with a water-miscible organic solution, in which a phospholipid and cholesterol are contained at a defined total concentration, at a defined ratio by volume thereby obtaining an emulsion wherein a total concentration of the phospholipid and cholesterol in the mixed phase is at 15 w/v % to 50 w/v %, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution to obtain a liposome composition wherein an ion gradient is formed between an internal-region aqueous phase of a liposome membrane made of the first aqueous phase solution and an external-region aqueous phase of the liposome membrane made of the second aqueous phase solution; and encapsulating a local anesthetic in the internal-region aqueous phase according to a remote loading method.
    Type: Application
    Filed: March 19, 2015
    Publication date: September 10, 2015
    Applicants: Kansai Medical University Educational Corporation, Terumo Kabushiki Kaisha
    Inventors: Keiko YAMASHITA, Yasuo KUROSAKI, Makoto HARUMOTO, Kyoko SHIMAMURA, Masaki KAIBORI, Yoshiro ARAKI, Masanori KON, Seiji ITO