Patents by Inventor Makoto Hazama

Makoto Hazama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10770281
    Abstract: An ion trap includes: an ion trap including a plurality of electrodes; a rectangular voltage generator including a voltage source for generating a direct voltage and a switching section, the rectangular voltage generator configured to operate the switching section to generate a rectangular voltage by switching the direct voltage generated by the voltage source and to apply the rectangular voltage to at least one of the plurality of electrodes; and a switching section temperature controller configured to control a temperature of the switching section so as to maintain the temperature of the switching section at a target temperature which is higher than a highest reaching temperature of the switching section.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: September 8, 2020
    Assignee: Shimadzu Corporation
    Inventor: Makoto Hazama
  • Publication number: 20200152438
    Abstract: A mass spectrometer includes a MALDI ion source, an ion separator that separates ions generated from the MALDI ion source, a detector that detects ions ejected from the ion separator, a data processor that acquires a mass spectrum of the ion detected in the detector, and a controller that controls intensity of laser light with which the MALDI ion source is irradiated. The controller includes a determiner that determines whether a peak of a matrix is detected in the mass spectrum acquired in the data processor while increasing intensity of laser light emitted to a sample matrix mixture from a first intensity, and a setter that acquires intensity of laser light at a time point at which the peak of the matrix is detected as a second intensity, and sets the second intensity as intensity of laser light used for analysis of the sample.
    Type: Application
    Filed: August 19, 2019
    Publication date: May 14, 2020
    Applicant: Shimadzu Corporation
    Inventor: Makoto HAZAMA
  • Publication number: 20200090921
    Abstract: An ion trap includes: an ion trap including a plurality of electrodes; a rectangular voltage generator including a voltage source for generating a direct voltage and a switching section, the rectangular voltage generator configured to operate the switching section to generate a rectangular voltage by switching the direct voltage generated by the voltage source and to apply the rectangular voltage to at least one of the plurality of electrodes; and a switching section temperature controller configured to control a temperature of the switching section so as to maintain the temperature of the switching section at a target temperature which is higher than a highest reaching temperature of the switching section.
    Type: Application
    Filed: March 1, 2018
    Publication date: March 19, 2020
    Applicant: Shimadzu Corporation
    Inventor: Makoto HAZAMA
  • Publication number: 20190143612
    Abstract: A fiber-reinforced resin hollow body includes an axial-direction fiber layer containing reinforcing fibers aligned parallel to an axial direction of the hollow body, and a non-axial-direction fiber layer provided on top of at least one of an internal and an external side of the axial-direction fiber layer, and containing reinforcing fibers oriented in a direction different from the alignment direction of the axial-direction fiber layer. The non-axial-direction fiber layer includes one or more peripheral-direction fiber layers containing reinforcing fibers aligned parallel to a peripheral direction of the hollow body, and one or more non-aligned fiber layers containing reinforcing fibers not aligned in a specific direction.
    Type: Application
    Filed: March 29, 2017
    Publication date: May 16, 2019
    Applicants: KURIMOTO, LTD., MAZDA MOTOR CORPORATION
    Inventors: Takeshi KITAGAWA, Masaya HAZAMA, Toshiki OKAUJI, Makoto TAKEDA, Jun WATANABE, Takashi TABAKOYA, Shin MATSUMURA, Yoshiyasu KAJIMOTO, Kazuhisa TO
  • Patent number: 9396923
    Abstract: Provided is an ion selection method capable of isolating and leaving a target ion in an ion trap within a short period of time and with high separating power. In a digital ion trap, after ions over a wide range of m/z near a target ion are selectively retained by rough isolation using an FNF signal or the like (S11), unnecessary ions on a low-mass side are removed with high separating power by changing the duty ratio of a rectangular voltage (S12). Furthermore, unnecessary ions on a high-mass side are removed with high separating power by resonant excitation discharge (S13).
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: July 19, 2016
    Assignee: SHIMADZU CORPORATION
    Inventors: Kei Kodera, Makoto Hazama
  • Publication number: 20150255263
    Abstract: Provided is an ion selection method capable of isolating and leaving a target ion in an ion trap within a short period of time and with high separating power. In a digital ion trap, after ions over a wide range of m/z near a target ion are selectively retained by rough isolation using an FNF signal or the like (S11), unnecessary ions on a low-mass side are removed with high separating power by changing the duty ratio of a rectangular voltage (S12). Furthermore, unnecessary ions on a high-mass side are removed with high separating power by resonant excitation discharge (S13).
    Type: Application
    Filed: September 6, 2013
    Publication date: September 10, 2015
    Applicant: SHIMADZU CORPORATION
    Inventors: Kei Kodera, Makoto Hazama
  • Patent number: 8306756
    Abstract: To enable accurate analysis of a base sequence even in an electrophoretic pattern containing a degraded part.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: November 6, 2012
    Assignee: Shimadzu Corporation
    Inventors: Shinichi Utsunomiya, Makoto Hazama
  • Publication number: 20120119083
    Abstract: Ions supplied in the form of a pulse are introduced into an ion trap through an ion entering orifice while a rectangular voltage of a frequency higher than the frequency at which the best trap is accomplished is applied to a ring electrode from a trap voltage generating unit. With this, since a well of a pseudo ion potential is formed in a radial direction in the ion trap, the spread of ions of low m/z values introduced previously is suppressed. A part of ions is introduced into the ion trap, and thereafter the frequency of the rectangular voltage applied to the ring electrode is lowered stepwise to the frequency at which the best trap is accomplished. As a result, the ions of the low m/z values introduced previously can be efficiently trapped, and introduction of ions of high m/z values reaching the ion trap later is not hindered.
    Type: Application
    Filed: March 30, 2009
    Publication date: May 17, 2012
    Applicant: SHIMADZU CORPORATION
    Inventors: Kei Kodera, Makoto Hazama, Shinichi Iwamoto, Sadanori Sekiya
  • Patent number: 8155889
    Abstract: Disclosed herein is a method for assessing the degree of reliability of a nucleic acid base sequence, by which a higher-accuracy assessment result of the degree of reliability can be obtained as compared to a case where the degree of reliability is assessed based on only the evaluation of analytical data. The method includes the steps: (A) when measured data is processed into analytical data, computing a processing evaluation value E1i for evaluating quality of measured data of an i-th base and contents of processing having been performed on the measured data of the i-th base; (B) computing an analytical data evaluation value E2i of the i-th base based on the processed analytical data; and (C) computing a degree of reliability by a predetermined calculation formula using the processing evaluation value E1i and the analytical data evaluation value E2i.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: April 10, 2012
    Assignee: Shimadzu Corporation
    Inventors: Shinichi Utsunomiya, Makoto Hazama
  • Publication number: 20100089771
    Abstract: To enable accurate analysis of a base sequence even in an electrophoretic pattern containing a degraded part.
    Type: Application
    Filed: October 26, 2006
    Publication date: April 15, 2010
    Inventors: Shinichi Utsunomiya, Makoto Hazama
  • Publication number: 20100070189
    Abstract: Disclosed herein is a method for assessing the degree of reliability of a nucleic acid base sequence, by which a higher-accuracy assessment result of the degree of reliability can be obtained as compared to a case where the degree of reliability is assessed based on only the evaluation of analytical data. The method includes the steps: (A) when measured data is processed into analytical data, computing a processing evaluation value E1i for evaluating quality of measured data of an i-th base and contents of processing having been performed on the measured data of the i-th base; (B) computing an analytical data evaluation value E2i of the i-th base based on the processed analytical data; and (C) computing a degree of reliability by a predetermined calculation formula using the processing evaluation value E1i and the analytical data evaluation value E2i.
    Type: Application
    Filed: December 4, 2006
    Publication date: March 18, 2010
    Inventors: Shinichi Utsunomiya, Makoto Hazama
  • Patent number: 7655125
    Abstract: For automating the operation of an electrophoresis apparatus and improving the throughput, the present electrophoresis apparatus has two platens capable of controlling temperature of electrophoresis plates placed thereon, a loading medium charging unit for sending a loading medium under pressure, a loading medium charging nozzle mechanism having a pair of nozzles connected to the loading medium charging unit, a pipetter mechanism for dispensing samples to sample dispensing openings of the electrophoresis plates placed on the platens, a stacker mechanism for storing sample plates, a loading buffer solution supplying mechanism, a loading buffer solution dispensing mechanism connected to the loading buffer solution supplying mechanism, a power unit for allowing electrophoresis separation for each electrophoresis plate placed on the platens, and a detector for optically detecting components migrating through each electrophoresis flow channel of the electrophoresis plates.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: February 2, 2010
    Assignee: Shimadzu Corporation
    Inventors: Shin Nakamura, Rintaro Yamamoto, Akira Harada, Makoto Hazama, Takashi Ikegami, Toru Kaji, Naoya Endo, Hidesato Kumagai, Tetsuo Ohashi, Atsushi Inami, Keisuke Miyamoto, Shinichi Utsunomiya
  • Publication number: 20080087547
    Abstract: For automating the operation of an electrophoresis apparatus and improving the throughput, the present electrophoresis apparatus has two platens capable of controlling temperature of electrophoresis plates placed thereon, a loading medium charging unit for sending a loading medium under pressure, a loading medium charging nozzle mechanism having a pair of nozzles connected to the loading medium charging unit, a pipetter mechanism for dispensing samples to sample dispensing openings of the electrophoresis plates placed on the platens, a stacker mechanism for storing sample plates, a loading buffer solution supplying mechanism, a loading buffer solution dispensing mechanism connected to the loading buffer solution supplying mechanism, a power unit for allowing electrophoresis separation for each electrophoresis plate placed on the platens, and a detector for optically detecting components migrating through each electrophoresis flow channel of the electrophoresis plates.
    Type: Application
    Filed: October 2, 2007
    Publication date: April 17, 2008
    Applicant: SHIMADZU CORPORATION
    Inventors: Shin Nakamura, Rintaro Yamamoto, Akira Harada, Makoto Hazama, Takashi Ikegami, Toru Kaji, Naoya Endo, Hidesato Kumagai, Tetsuo Ohashi, Atsushi Inami, Keisuke Miyamoto, Shinichi Utsunomiya
  • Patent number: 7195698
    Abstract: An electrode plate of a sample plate is set on the body of an electrophoretic apparatus, while a plug is inserted into a migration high voltage line connection hole and connected to a high-tension distribution cable. Each well of a base plate is inserted into a through hole of a well guide and further press-fit and engaged into a cavity of an electrode plate, for fixing the base plate to the electrode plate. Thereafter a sample is introduced into each well of the base plate and an end of a capillary column is dipped into each well for applying a migration voltage and electrophoretically injecting the sample into the capillary column.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: March 27, 2007
    Assignees: The Institute of Physical and Chemical Research, Shimadzu Corporation, Japan Science and Technology Corporation
    Inventors: Yoshihide Hayashizaki, Shin Nakamura, Makoto Hazama, Hideshi Fujiwake
  • Patent number: 7006925
    Abstract: Waveform shaping by Fourier transformation is performed on data of N points from the head of detected data with a parameter of a previously set peak interval (S1, S2), base sequence is determined as to data of M points (M<N) from the head of the data of N points (S3), and a peak interval is obtained from the result of the sequence determination (S4). Waveform shaping by Fourier transformation is performed on data of N points from a position returning by L points (L<M) from final data of M points subjected to the sequence determination with a parameter of a precedently obtained peak interval, and thereafter the sequence determination, peak interval calculation and waveform shaping are similarly repeated. Thus, noise can be removed on the basis of Fourier transformation also as to a data section where a migration speed changes, for precisely determining the base sequence.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: February 28, 2006
    Assignee: Shimadzu Corporation
    Inventor: Makoto Hazama
  • Publication number: 20040217004
    Abstract: An electrode plate of a sample plate is set on the body of an electrophoretic apparatus, while a plug is inserted into a migration high voltage line connection hole and connected to a high-tension distribution cable. Each well of a base plate is inserted into a through hole of a well guide and further press-fit and engaged into a cavity of an electrode plate, for fixing the base plate to the electrode plate. Thereafter a sample is introduced into each well of the base plate and an end of a capillary column is dipped into each well for applying a migration voltage and electrophoretically injecting the sample into the capillary column.
    Type: Application
    Filed: December 13, 2002
    Publication date: November 4, 2004
    Inventors: Yoshihide Hayashizaki, Shin Nakamura, Makoto Hazama, Hideshi Fujiwake
  • Patent number: 6517696
    Abstract: An electrode plate of a sample plate is set on the body of an electrophoretic apparatus, while a plug is inserted into a migration high voltage line connection hole and connected to a high-tension distribution cable. Each well of a base plate is inserted into a through hole of a well guide and further press-fit and engaged into a cavity of an electrode plate, for fixing the base plate to the electrode plate. Thereafter a sample is introduced into each well of the base plate and an end of a capillary column is dipped into each well for applying a migration voltage and electrophoretically injecting the sample into the capillary column.
    Type: Grant
    Filed: October 26, 1999
    Date of Patent: February 11, 2003
    Assignees: The Institute of Physical and Chemical Research, Shimadzu Corporation, Japan Science and Technology Corporation
    Inventors: Yoshihide Hayashizaki, Shin Nakamura, Makoto Hazama, Hideshi Fujiwake
  • Publication number: 20020090634
    Abstract: Waveform shaping by Fourier transformation is performed on data of N points from the head of detected data with a parameter of a previously set peak interval (S1, S2), base sequence is determined as to data of M points (M<N) from the head of the data of N points (S3), and a peak interval is obtained from the result of the sequence determination (S4). Waveform shaping by Fourier transformation is performed on data of N points from a position returning by L points (L<M) from final data of M points subjected to the sequence determination with a parameter of a precedently obtained peak interval, and thereafter the sequence determination, peak interval calculation and waveform shaping are similarly repeated. Thus, noise can be removed on the basis of Fourier transformation also as to a data section where a migration speed changes, for precisely determining the base sequence.
    Type: Application
    Filed: December 6, 2001
    Publication date: July 11, 2002
    Applicant: SHIMADZU CORPORATION
    Inventor: Makoto Hazama
  • Publication number: 20020090630
    Abstract: Peaks are extracted in a certain range of starting points of signals from migration waveforms. The peaks are classified on the basis of signal strengths for obtaining signal strength ratios of four groups classified. Corresponding bases are allocated to the four groups classified for obtaining a matrix value from the signal strength ratios of peak waveforms of the respective base groups. Base sequence is determined with the matrix value. Thus, the matrix value can be obtained from actual sample migration without employing an exclusive reagent kit.
    Type: Application
    Filed: November 26, 2001
    Publication date: July 11, 2002
    Applicant: Shimadzu Corporation
    Inventor: Makoto Hazama
  • Patent number: 5395594
    Abstract: The present invention is directed to a simultaneous multiple chemical synthesizer comprising a number of reaction vessels wherein each vessel has a filter in the bottom portion thereof, a number of needles wherein each needle is connected to an aspiration injection line of a reaction mixture and a gas supply line in connection with each reaction vessel and each needle does not touch the resin contained in the reaction vessel, a number of arms which are horizontally and vertically movable and hold the respective needles, a bubbling gas line and a waste discharge line in connection with each reaction vessel, wherein each line is connected to the bottom portion of each reaction vessel, a number of purging means which move synchronously with said waste discharge lines, and means for washing the portions of the needles and purge means which contact with the reaction reagents.
    Type: Grant
    Filed: August 24, 1992
    Date of Patent: March 7, 1995
    Assignee: Shimadzu Corporation
    Inventors: Kiyoshi Nokihara, Makoto Hazama, Rintaro Yamamoto, Shin Nakamura