Patents by Inventor Makoto Higuchi

Makoto Higuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250064992
    Abstract: The purpose of the present invention is to provide a technique for imaging the brain of a live animal and application of the technique. A radiolabeled dibenzoazepine derivative, which shows excellent brainparmeability, high receptor selectivity and high quantitativity, is used for imaging a live animal body. A dibenzoazepine derivative is used for treating a disease in which hM4D receptor or hM3D receptor participates. Further, a radiolabeled dibenzoazepine derivative is used for imaging an axonal end which is innervated by a nerve cell.
    Type: Application
    Filed: November 7, 2024
    Publication date: February 27, 2025
    Applicant: National Institutes for Quantum and Radiological Science and Technology
    Inventors: Takafumi MINAMIMOTO, Yuji NAGAI, Bin JI, Naohisa MIYAKAWA, Makoto HIGUCHI, Tetsuya SUHARA
  • Patent number: 12195454
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Grant
    Filed: May 8, 2023
    Date of Patent: January 14, 2025
    Assignee: National Institutes for Quantum and Radiological Science and Technology
    Inventors: Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Meiei Cho, Hitoshi Shimada
  • Publication number: 20240397008
    Abstract: When scanning a document, an image scanning device conveys the document toward an image scanning position in a power supply stop state in which power supply to an electronic component is stopped, sets a power supply state in which power is supplied to the electronic component before scanning the document at the image scanning position, scans the document at the image scanning position in the power supply state, and sets the power supply stop state after scanning the document at the image scanning position.
    Type: Application
    Filed: May 21, 2024
    Publication date: November 28, 2024
    Inventors: SHOHICHI FUKUTOME, MAKOTO HIGUCHI
  • Publication number: 20240083893
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Application
    Filed: May 8, 2023
    Publication date: March 14, 2024
    Applicant: National Institutes for Quantum and Radiological Science and Technology
    Inventors: Makoto HIGUCHI, Tetsuya SUHARA, Masahiro MARUYAMA, Meiei CHO, Hitoshi SHIMADA
  • Publication number: 20230399323
    Abstract: An embodiment of the present invention relates to a compound represented by formula (I) or (II), a pharmaceutically acceptable salt thereof, or a solvate thereof.
    Type: Application
    Filed: August 24, 2021
    Publication date: December 14, 2023
    Inventors: Makoto Higuchi, Maiko Ono, Meiei Cho, Takeshi Yamamoto, Takeshi Wakabayashi
  • Patent number: 11667628
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: June 6, 2023
    Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY
    Inventors: Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Meiei Cho, Hitoshi Shimada
  • Publication number: 20230109839
    Abstract: The present invention is to provide a medicament for treating and/or preventing tauopathy by activating the voltage-gated sodium channel (Nav). The present invention relates to a medicament for treating and/or preventing tauopathy, comprising a Nav activator as an active ingredient.
    Type: Application
    Filed: January 6, 2021
    Publication date: April 13, 2023
    Applicant: SUMITOMO PHARMA CO., LTD.
    Inventors: Kazuaki SAMPEI, Takeo ISHIYAMA, Atsushi IKEDA, Taizo ISHIKAWA, Makoto HIGUCHI, Hiroyuki TAKUWA, Yuhei TAKADO
  • Patent number: 11555773
    Abstract: An inflammatory marker is calculated using a nonlinear function including, as variables, a parameter associated with an erythrocyte aggregation and another parameter associated with an erythrocyte density. The parameter associated with the erythrocyte aggregation is calculated based on a syllectogram measured from a blood specimen. The parameter associated with the erythrocyte density is measured from the blood specimen.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: January 17, 2023
    Assignee: NIHON KOHDEN CORPORATION
    Inventor: Makoto Higuchi
  • Publication number: 20220296548
    Abstract: A prophylactic or therapeutic agent for tauopathy, containing an inhibitor of ?2? of the voltage-dependent calcium channel is provided by the present invention.
    Type: Application
    Filed: October 20, 2020
    Publication date: September 22, 2022
    Inventors: Haruhisa Inoue, Keiko Imamura, Makoto Higuchi, Naruhiko Sahara, Maiko Ono
  • Publication number: 20220133698
    Abstract: The present invention provides an ?-synuclein aggregate binding agent that has high binding selectivity for an ?-synuclein aggregate. The ?-synuclein aggregate binding agent contains a compound represented by a formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: in the formula (I), R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; the ring A is a benzene or pyridine ring; the ring B is represented by the following formula (i) or (ii): R4 and R5 are each independently selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 5, 2022
    Inventors: Makoto Higuchi, Maiko Ono, Tetsuya Suhara, Meiei Cho
  • Publication number: 20220056020
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Application
    Filed: September 16, 2021
    Publication date: February 24, 2022
    Inventors: Makoto HIGUCHI, Tetsuya SUHARA, Masahiro MARUYAMA, Meiei CHO, Hitoshi SHIMADA
  • Patent number: 11122177
    Abstract: An image reading device reads two types of documents, a first document having a first size and a second document having a second size larger than the first size. A controller of the device causes the first document reader to read the first document and generate image data when the operation unit accepts a command. The first document reader reads a portion of the second document and generates image data on tilt of the second document when the operation unit accepts a command. The document tilt detector detects tilt of the second document based on the image data for detecting tilt of the second document. The document transporter stops transport of the second document when the document tilt detector detects tilt of the second document. The second document reader reads the second document and generates image data when the document tilt detector detects no tilt of the second document.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: September 14, 2021
    Assignee: SHARP KABUSHIKI KAISHA
    Inventors: Noritomo Nakashima, Makoto Higuchi
  • Publication number: 20210275696
    Abstract: The purpose of the present invention is to provide a technique for imaging the brain of a live animal and application of the technique. A radiolabeled dibenzoazepine derivative, which shows excellent brain parmeability, high receptor selectivity and high quantitativity, is used for imaging a live animal body. A dibenzoazepine derivative is used for treating a disease in which hM4D receptor or hM3D receptor participates. Further, a radiolabeled dibenzoazepine derivative is used for imaging an axonal end which is innervated by a nerve cell.
    Type: Application
    Filed: June 21, 2019
    Publication date: September 9, 2021
    Applicant: National Institutes for Quantum and Radiological Science and Technology
    Inventors: Takafumi MINAMIMOTO, Yuji NAGAI, Bin JI, Naohisa MIYAKAWA, Makoto HIGUCHI, Tetsuya SUHARA
  • Publication number: 20210044713
    Abstract: An image reading device reads two types of documents, a first document having a first size and a second document having a second size larger than the first size. A controller of the device causes the first document reader to read the first document and generate image data when the operation unit accepts a command. The first document reader reads a portion of the second document and generates image data on tilt of the second document when the operation unit accepts a command. The document tilt detector detects tilt of the second document based on the image data for detecting tilt of the second document. The document transporter stops transport of the second document when the document tilt detector detects tilt of the second document. The second document reader reads the second document and generates image data when the document tilt detector detects no tilt of the second document.
    Type: Application
    Filed: July 17, 2020
    Publication date: February 11, 2021
    Inventors: NORITOMO NAKASHIMA, MAKOTO HIGUCHI
  • Publication number: 20200262829
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and [Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Application
    Filed: February 21, 2020
    Publication date: August 20, 2020
    Inventors: Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Meiei Cho, Hitoshi Shimada
  • Patent number: 10604516
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and ??[Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 31, 2020
    Assignee: National Institutes for Quantum and Radiological Science and Technology
    Inventors: Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Meiei Cho, Hitoshi Shimada
  • Publication number: 20200059567
    Abstract: A data communication device that performs e-mail communication includes: an e-mail transmitter that attaches an image to an e-mail, and then transmits the e-mail; an image data detector that detects a data amount of an input image; an image data amount determiner that determines whether or not a data amount of the image attached to the e-mail exceeds a preset data amount; a communication controller that enables transmission of the e-mail if the data amount of the image does not exceed the preset data amount; and a data amount controller that performs data amount reduction processing of reducing the image data amount if the data amount of the image exceeds the preset data amount.
    Type: Application
    Filed: July 23, 2019
    Publication date: February 20, 2020
    Inventors: MAKOTO HIGUCHI, MOTOHIRO HAYASHI
  • Publication number: 20200018677
    Abstract: An inflammatory marker is calculated using a nonlinear function including, as variables, a parameter associated with an erythrocyte aggregation and another parameter associated with an erythrocyte density. The parameter associated with the erythrocyte aggregation is calculated based on a syllectogram measured from a blood specimen. The parameter associated with the erythrocyte density is measured from the blood specimen.
    Type: Application
    Filed: January 25, 2018
    Publication date: January 16, 2020
    Inventor: Makoto HIGUCHI
  • Publication number: 20190351177
    Abstract: A temperature adjuster (20) is configured to adjust temperature associated with a first gas supplying medium (10) for providing first gas to be mixed. A first flow rate controller (30) is configured to control a flow rate of the first gas. A second flow rate controller (40) is configured to control a flow rate of second gas to be mixed that is different from the first gas. A mixer (50) is configured to supply mixed gas in which the first gas supplied by the first flow rate controller (30) and the second gas supplied by the second flow rate controller (40) have been mixed.
    Type: Application
    Filed: January 10, 2018
    Publication date: November 21, 2019
    Inventors: Makoto HIGUCHI, Kentaro SUZUKI, Toshihiro URANO
  • Patent number: 10335503
    Abstract: The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. (In the formula, each of A and Z independently represents CO, SO or SO2; each of X and Y independently represents S or O; each of R1-R4 independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each R5 independently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.) This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: July 2, 2019
    Assignee: Public University Corporation Yokohama City University
    Inventors: Takuya Takahashi, Tomoyuki Miyazaki, Tetsuya Suhara, Makoto Higuchi, Meiei Cho