Abstract: Compositions and methods for treating diabetes in a canine are provided. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a canine insulin polypeptide.

Abstract: Compositions and methods for treating type II diabetes in a feline are provided. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a feline GLP-1 receptor agonist.

Abstract: Compositions and methods for treating metabolic diseases in a subject are provided. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a GLP-1 receptor agonist fusion protein and regulatory sequences which direct expression thereof.

Abstract: Provided herein are nucleic acid molecules, vectors, and recombinant AAV comprising an inducible gene expression system. The system includes a transgene encoding a gene product operably linked to expression control sequences comprising a promoter; an activation domain comprising a canine or feline transactivation domain and a FKBP12-rapamycin binding (FRB) domain of canine or feline FKBP12-rapamycin-associated protein (FRAP); a DNA binding domain comprising a zinc finger homeodomain (ZFHD) and one, two or three FK506 binding protein domain (FKBP) subunit genes; and at least 8 copies of the binding site for ZFHD (8XZFHD) followed by a minimal IL2 promoter. The presence of an effective amount of a rapamycin or a rapalog induces expression of the transgene in a host cell.

Abstract: Provided herein are compositions useful for co-administering with a gene therapy vector to a patient having pre-existing neutralizing antibodies to the viral source of the gene therapy vector capsid. The compositions comprise an FcRn ligand which inhibits specific binding between FcRn and IgG.

Abstract: The objective of the present invention is to efficiently manage data required to verify the loading waiting time of a logistics contractor (truck driver), while ensuring the accuracy of the data. A metadata storage control unit 103 executes control to cause metadata relating to main data to be stored on a network N using blockchain technology or distributed ledger technology. A main data storage control unit 104 executes control to associate linking data linking metadata stored on the network N and the main data with the main data, and to store the same in a main data database 181 on a server 1.

Abstract: Provided is a medical image management apparatus including a hardware processor that records, when an image interpretation report on a plurality of medical images obtained in a single examination is created, a display time for which each of the plurality of images is displayed during creation of the image interpretation report, and controls, when the plurality of medical images in the single examination is viewed, a viewing speed of each of the plurality of medical images based on the recorded display time of each of the plurality of images during creation of the image interpretation report.

Abstract: The present invention is for calculating a distribution fee for when an article is transported by a moving body. According to the present invention, an article-characteristic-information acquisition unit 81 acquires article characteristic information that has been transmitted from a storage site terminal 3-Q. A moving-body-characteristic-information acquisition unit 82 acquires moving body characteristic information that has been transmitted from the storage site terminal 3-Q. When input information has been transmitted from a user terminal 2, an input-information acquisition unit 80 acquires the input information that has been transmitted from the user terminal 2-P.

Abstract: An ultrasound diagnosis apparatus generates an ultrasound image of an inside of a subject on a basis of ultrasound signals which are reflected off at the inside of the subject and received. The apparatus includes a needle position specifier and a needle emphasis processor. With respect to each region in the ultrasound image, the needle position specifier obtains a deep region feature value relating to signal intensity in a region deeper than a region subject to judgment in relation to ultrasound signal distribution along an emission direction of an ultrasound emitted in a subject, and specifies a position of a puncture-needle which is inserted in the subject. The needle emphasis processor carries out a process for emphasizing the position of the puncture-needle which is specified in the ultrasound image.

Abstract: Provided is a medical image management apparatus including a hardware processor that records, when an image interpretation report on a plurality of medical images obtained in a single examination is created, a display time for which each of the plurality of images is displayed during creation of the image interpretation report, and controls, when the plurality of medical images in the single examination is viewed, a viewing speed of each of the plurality of medical images based on the recorded display time of each of the plurality of images during creation of the image interpretation report.

Abstract: The present invention makes it possible for a person (a sender or a third party) that is not on a production side or a distribution side to form a distribution plan. According to the present invention, a received-order-information acquisition unit 61 acquires sender S side received-order information. (information on an order from a customer C or information on an order placed to a vendor V (a production/supply source)) from a sender terminal 3 or a vendor terminal 4 via a communication unit 19. A received-order-to-distribution conversion unit 62 converts the acquired received-order information into distribution information. (information on arrival from the vendor V (the production/supply source), information on shipping to the customer C). A parameter acquisition unit 63 acquires, from a parameter DB 71, parameters that include at least deadline, cost, and quality (accident rate).

Abstract: When a moving body is to receive a new, additional article for transport, the present invention makes it possible for the new, additional article to be received for transport with consideration given not only to restrictions on the weight that can be transported by the moving body but also to restrictions on driver compliance. According to the present invention, a present-situation-information acquisition unit 71 acquires: respective characteristic values for one or more articles that include a prescribed article and are being transported by a moving body; and present transport conditions that include respective transport routes for the one or more articles. An additional-conditions acquisition unit 72 acquires: a characteristic value for an additional article; and additional transport conditions that include a transport route for the additional article.

Abstract: The present invention is for calculating a distribution fee for when an article is transported by a moving body. According to the present invention, an article-characteristic-information acquisition unit 81 acquires article characteristic information that has been transmitted from a storage site terminal 3-Q. A moving-body-characteristic-information acquisition unit 82 acquires moving body characteristic information that has been transmitted from the storage site terminal 3-Q. When input information has been transmitted from a user terminal 2, an input-information acquisition unit 80 acquires the input information that has been transmitted from the user terminal 2-P.

Abstract: An ultrasound diagnosis apparatus generating an ultrasound image of inside of a test object based on ultrasound signals reflected and received from the inside of the test object includes: a candidate region extracting unit which extracts a plurality of candidate detection regions in a needle position range corresponding to a position of a puncture needle inserted into the test object; a needle identification range setting unit which determines a needle identification range including the needle position range from the ultrasound image based on the extracted candidate detection regions; a needle position range estimating unit which determines an estimated range of the needle position range in the needle identification range based on a value indicating an aggregation state related to a distribution of the candidate detection regions in the needle identification range; and a needle emphasizing unit which performs a process for emphasizing the estimated range in the ultrasound image.

Abstract: Provided is a feature with which it is possible to successively determine the optimum route of a mobile entity and, as a result thereof, effectively operate a service or the like of keeping goods from a user in custody. A base information management unit 50 retrieves (manages) base information and transmits same to a server 1. A warehouse information management unit 70 retrieves (manages) warehouse information and transmits same to the server 1. A base information retrieval unit 80 retrieves the base information transmitted from a base terminal 2. A warehouse information retrieval unit 81 retrieves warehouse information transmitted from a warehouse terminal 3. A route determination unit 82 determines an optimum route from the base information and warehouse information retrieved by the sever 1 and determines the use information of a user.

Abstract: A medical image management device includes a hardware processor that causes a mobile terminal to display a medical image thereon and transmits related information concerning the medical image via the mobile terminal at least in a part of a time period when the medical image is being displayed on the mobile terminal. The hardware processor varies a transmission target part of the related information over time.

Abstract: A light-emitting module includes a substrate, an LED chip arranged on a main surface of the substrate, a sealing member covering the LED chip on the main surface of the substrate and converting a wavelength of the light produced by the LED chip, and a heat transfer member thermally connecting the sides of the LED chip to the main surface of the substrate and dissipating heat produced by the LED chip to the substrate. The heat transfer member is made up of a silicone resin having particles dispersed therein, the particles being nanoparticles of ZrO2 and microparticles of MgO, which have higher thermal conductivity than the silicone resin.

Abstract: A catalyst for use in a process for purifying exhaust gas from a gasoline engine of the fuel-direct-injection type that varies, in response to changes in the air-fuel ratio, between a first exhaust-gas state featured by an air-fuel ratio in the vicinity of the stoichiometrical air-fuel ratio, and a second exhaust-gas state that forms a more oxidizing, low-temperature atmosphere and that is featured by an air-fuel ratio greater than the stoichiometrical air-fuel ratio, the catalyst being obtained by causing a noble metal and a rare-earth oxide and/or a transition metal to be carried by or to be mixed with a fire-resistant inorganic oxide.

Abstract: An ultrasound diagnosis apparatus generating an ultrasound image of inside of a test object based on ultrasound signals reflected and received from the inside of the test object includes: a candidate region extracting unit which extracts a plurality of candidate detection regions in a needle position range corresponding to a position of a puncture needle inserted into the test object; a needle identification range setting unit which determines a needle identification range including the needle position range from the ultrasound image based on the extracted candidate detection regions; a needle position range estimating unit which determines an estimated range of the needle position range in the needle identification range based on a value indicating an aggregation state related to a distribution of the candidate detection regions in the needle identification range; and a needle emphasizing unit which performs a process for emphasizing the estimated range in the ultrasound image.

Abstract: An ultrasound diagnosis apparatus generates an ultrasound image of an inside of a subject on a basis of ultrasound signals which are reflected off at the inside of the subject and received. The apparatus includes a needle position specifier and a needle emphasis processor. With respect to each region in the ultrasound image, the needle position specifier obtains a deep region feature value relating to signal intensity in a region deeper than a region subject to judgment in relation to ultrasound signal distribution along an emission direction of an ultrasound emitted in a subject, and specifies a position of a puncture-needle which is inserted in the subject. The needle emphasis processor carries out a process for emphasizing the position of the puncture-needle which is specified in the ultrasound image.