Patents by Inventor Makoto Kakiuchi

Makoto Kakiuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200155764
    Abstract: A dual chamber prefillable syringe (100) includes: a cylinder (10) which has a bypass portion (11); a hub luer-lock (20); a front stopper (30); a middle stopper (40) which seals a preparation (S) together with the front stopper (30); an end stopper (50) which seals a solvent (L) together with the middle stopper (40); a finger grip (60); and a plunger rod (70) which is connected to the end stopper from the rear end side. A female screw portion (64) which is screwed around the axis line is formed on an inner circumferential surface of the finger grip (60), and a male screw portion (73) which is able to be screwed to the female screw portion is formed on an outer circumferential surface of the plunger rod (70).
    Type: Application
    Filed: November 15, 2019
    Publication date: May 21, 2020
    Applicants: ARTE CORPORATION, OTSUKA PHARMACEUTICAL CO. LTD.
    Inventors: Makoto KAKIUCHI, Seiji SHIMAZAKI, Yasuhiko TAKESHIMA, Shogo HIRAOKA, Tadayoshi MAESAKA
  • Patent number: 9919094
    Abstract: A cartridge set including: a plurality of cartridges; a plurality of holders, each of which has an upper end externally fitted to the outer peripheral surface of each of the cartridges, and has a lower end face whose outer diameter is greater than the outer diameter of the outer peripheral surface of the cartridge; a supporting plate that has a plurality of through-holes, each of which has an inner diameter greater than the outer diameter of the outer peripheral surface of the cartridge and has each of the plurality of cartridges inserted therethrough; a storage box that stores the supporting plate therein; and a lid member that blocks an upper end opening of the storage box.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: March 20, 2018
    Assignee: ARTE CORPORATION
    Inventors: Seiji Shimazaki, Makoto Kakiuchi, Teruo Matsuda
  • Patent number: 9636463
    Abstract: A combination container/syringe (1) provided with an outer cylinder (10) that forms a cylindrical shape centered on an axial line (O); a front stopper that is inserted into a distal end side of the outer cylinder (10); and a cylindrical tip (50) that is fitted to an outer periphery of the distal end of the outer cylinder via a fitting hole (61) at a base end side, and that has a bypass chamber (71) that houses the front stopper at a front side of the fitting hole, in which an inner diameter of the bypass chamber is formed larger than an outer diameter of the front stopper, and a plurality of ribs (74) that protrude toward an inside in a radial direction and extend in the direction of the axial line to make close contact with the outer peripheral surface of the front stopper that has moved to the inside of the bypass chamber are provided spaced apart in a circumferential direction on the inner peripheral surface (73) of the bypass chamber.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: May 2, 2017
    Assignee: ARTE CORPORATION
    Inventors: Makoto Kakiuchi, Harumi Kakiuchi, Seiji Shimazaki
  • Patent number: 9333147
    Abstract: A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: May 10, 2016
    Assignee: ARTE CORPORATION
    Inventors: Andreas Schuetz, Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda
  • Publication number: 20150041498
    Abstract: A device for accommodating a freeze-dried pharmaceutical product (S) for reconstitution, comprising: a vessel (1) having at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), wherein the front plunger (2) is configured to be positioned inside the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), and wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and outside of the vessel (1) in communication with each other when the
    Type: Application
    Filed: February 11, 2013
    Publication date: February 12, 2015
    Inventors: Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda, Andreas Schuetz
  • Patent number: 8684977
    Abstract: A combined container-syringe includes a body that has an outer tube to be filled with a drug solution. A cylindrical tip is attached to a front end portion of the outer tube and to a front end portion of which an injection needle is attached. A cylindrical safety device is attached on an outer circumferential surface of the outer tube in a freely sliding manner. A first retaining member fixes the safety device in a disengageable manner at a first position where the safety device is separated from the injection needle. A second retaining member fixes the safety device at a second position where the safety device covers the injection needle. A biasing member biases the safety device in the direction from the first position to the second position. A latch releasing member releases the engagement by the first retaining member.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: April 1, 2014
    Assignee: Arte Corporation
    Inventor: Makoto Kakiuchi
  • Publication number: 20140048432
    Abstract: A combination container/syringe (1) provided with an outer cylinder (10) that forms a cylindrical shape centered on an axial line (O); a front stopper that is inserted into a distal end side of the outer cylinder (10); and a cylindrical tip (50) that is fitted to an outer periphery of the distal end of the outer cylinder via a fitting hole (61) at a base end side, and that has a bypass chamber (71) that houses the front stopper at a front side of the fitting hole, in which an inner diameter of the bypass chamber is formed larger than an outer diameter of the front stopper, and a plurality of ribs (74) that protrude toward an inside in a radial direction and extend in the direction of the axial line to make close contact with the outer peripheral surface of the front stopper that has moved to the inside of the bypass chamber are provided spaced apart in a circumferential direction on the inner peripheral surface (73) of the bypass chamber.
    Type: Application
    Filed: February 2, 2012
    Publication date: February 20, 2014
    Applicant: Arte Corporation
    Inventors: Makoto Kakiuchi, Seiji Shimazaki
  • Publication number: 20130341849
    Abstract: A cartridge set including: a plurality of cartridges; a plurality of holders, each of which has an upper end externally fitted to the outer peripheral surface of each of the cartridges, and has a lower end face whose outer diameter is greater than the outer diameter of the outer peripheral surface of the cartridge; a supporting plate that has a plurality of through-holes, each of which has an inner diameter greater than the outer diameter of the outer peripheral surface of the cartridge and has each of the plurality of cartridges inserted therethrough; a storage box that stores the supporting plate therein; and a lid member that blocks an upper end opening of the storage box.
    Type: Application
    Filed: June 18, 2013
    Publication date: December 26, 2013
    Inventors: Seiji SHIMAZAKI, Makoto Kakiuchi, Teruo Matsuda
  • Patent number: 8517983
    Abstract: A dual chamber combined container-syringe includes: an outer casing having a bypass portion; a hub lure lock; a front stopper; a middle stopper that seals a pharmaceutical preparation together with the front stopper; an end stopper that seals a liquid medicine together with the middle stopper; a finger grip; and a plunger rod that is connected to the end stopper from the rear end side, wherein a female screw portion twisted around an axis is formed on an inner peripheral surface of the finger grip, and a first male screw portion, a tip of which comes into contact with a rear end of the female screw portion and can be screwed into the female portion, and a first guide plate are formed on an outer peripheral surface of the plunger rod when a part of the middle stopper enters the bypass portion.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: August 27, 2013
    Assignee: Arte Corporation
    Inventors: Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda
  • Publication number: 20130197467
    Abstract: A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and
    Type: Application
    Filed: August 8, 2011
    Publication date: August 1, 2013
    Applicant: ARTE CORPORATION
    Inventors: Andreas Schuetz, Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda
  • Publication number: 20120220951
    Abstract: A container-cum-syringe including a safety device, a coil spring which biases the safety device forward, first holding means for causing the safety device to be in a fastened state at a retreated position against the biasing of the coil spring, fastening releasing means which is provided slidably along a radial direction of an axis for releasing the fastened state of the safety device by the first holding means through a sliding movement, and locking means for locking the fastened state of the safety device by the first holding means are provided. In this configuration, the safety device may be easily moved to a position for covering the injection needle. In addition, a malfunction of the safety device during an injecting operation may be reliably prevented.
    Type: Application
    Filed: November 5, 2010
    Publication date: August 30, 2012
    Applicant: ARTE Corporation
    Inventor: Makoto Kakiuchi
  • Publication number: 20120118777
    Abstract: A packaging plate that supports a plurality of syringe bodies in an arranged state, including a first plate in which a plurality of support hole portions into which the syringe bodies are respectively inserted and each having a rectangular shape in plan view are formed, and an extension portion on which a flange portion of the syringe body is mounted is formed in each of these support hole portions; and a second plate that is stacked on and fixed to the upper surface of the first plate and in which through-holes through which the flange portion cannot pass are formed at locations corresponding to the support hole portions.
    Type: Application
    Filed: September 28, 2011
    Publication date: May 17, 2012
    Applicant: ARTE CORPORATION
    Inventors: Makoto KAKIUCHI, Seiji SHIMAZAKI
  • Publication number: 20120095394
    Abstract: A dual chamber combined container-syringe includes: an outer casing having a bypass portion; a hub lure lock; a front stopper; a middle stopper that seals a pharmaceutical preparation together with the front stopper; an end stopper that seals a liquid medicine together with the middle stopper; a finger grip; and a plunger rod that is connected to the end stopper from the rear end side, wherein a female screw portion twisted around an axis is formed on an inner peripheral surface of the finger grip, and a first male screw portion, a tip of which comes into contact with a rear end of the female screw portion and can be screwed into the female portion, and a first guide plate are formed on an outer peripheral surface of the plunger rod when a part of the middle stopper enters the bypass portion.
    Type: Application
    Filed: October 18, 2011
    Publication date: April 19, 2012
    Applicant: ARTE CORPORATION
    Inventors: Makoto KAKIUCHI, Seiji SHIMAZAKI, Teruo MATSUDA
  • Publication number: 20110174647
    Abstract: In a combined container-syringe, a rubber packing that covers the distal end opening of a cylinder at a fitting hole of a cylindrical tip in an air tight and liquid tight manner, and in which is formed a through hole that brings a communication hole formed in a lure tip and the inside of the cylinder into communication, and a rubber member that is inserted from the distal end side of the communication hole and blocks the through hole are provided, and the rubber packing is formed with an elastic body that is corrosion resistant to the liquid medicament. With this combined container-syringe, in addition to being able to store it for a long period without deteriorating the liquid medicament, it is possible to observe well the liquid medicament or blood that flows to the cylindrical tip, and moreover preventing leftover liquid medicament after injection becomes possible.
    Type: Application
    Filed: February 19, 2009
    Publication date: July 21, 2011
    Applicant: Arte Corporation
    Inventors: Seiji Shimazaki, Makoto Kakiuchi
  • Publication number: 20100198164
    Abstract: A combined container-syringe includes a body that has an outer tube to be filled with a drug solution. A cylindrical tip is attached to a front end portion of the outer tube and to a front end portion of which an injection needle is attached. A cylindrical safety device is attached on an outer circumferential surface of the outer tube in a freely sliding manner. A first retaining member fixes the safety device in a disengageable manner at a first position where the safety device is separated from the injection needle. A second retaining member fixes the safety device at a second position where the safety device covers the injection needle. A biasing member biases the safety device in the direction from the first position to the second position. A latch releasing member releases the engagement by the first retaining member.
    Type: Application
    Filed: April 27, 2009
    Publication date: August 5, 2010
    Applicant: ARTE CORPORATION
    Inventor: Makoto KAKIUCHI
  • Publication number: 20100190708
    Abstract: An object of the present invention is to obtain a composition, which is excellent in amelioration of a lipid metabolism disorder and has a preventive or ameliorating effect on hyperlipemia, obesity or type II diabetes induced by the lipid metabolism disorder, and is also economical and safe with respect to allergy, by extracting a rice bran extract containing a rice bran protein, followed by separation. Disclosed is a composition for amelioration of a lipid metabolism disorder, containing a rice bran protein.
    Type: Application
    Filed: January 19, 2010
    Publication date: July 29, 2010
    Inventors: Takuo Tsuno, Tetsuya Kariya, Makoto Kakiuchi, Yumi Minami, Atsushi Koyama, Takako Ishimoto
  • Publication number: 20100137800
    Abstract: A combined container-syringe includes: a cartridge; a needle hub having a base portion, a cylinder portion inside which a bypass chamber is formed, and a needle attachment portion inside which an introducing hole communicated with an injection needle is formed; a front stopper; a rear stopper; and a plunger rod connected to the rear stopper, in which: a bypass groove communicated with the introducing hole, and an annular groove connected to the bypass groove are formed on an inner circumferential surface of the bypass chamber; an air-bubble introducing groove is formed on an outer circumferential surface of the front stopper, the air-bubble introducing groove extending from a rear end surface of the front stopper toward a front end; and the air-bubble introducing groove and the annular groove are communicated with each other in a state where a part of the front stopper is disposed in the cartridge.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 3, 2010
    Applicant: ARTE CORPORATION
    Inventors: Makoto KAKIUCHI, Yasuhiko Takeshima
  • Patent number: 7727203
    Abstract: This combined container-syringe comprising a glass cylinder which can be pre-filled with a drug, an cylindrical tip provided at an exterior portion of an anterior end of the syringe, and a finger grip provided at an exterior portion of an posterior end of the syringe, and a drug is pre-filled therein and sealed by a stopper. Furthermore, an impact absorption part is provided around the exterior portion of the cylindrical tip and a diameter of the impact absorption part is greater than an outer diameter of a fitting part to the cylinder of the cylindrical tip.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: June 1, 2010
    Assignee: Arte Corporation
    Inventors: Seiji Shimazaki, Makoto Kakiuchi
  • Publication number: 20100130928
    Abstract: The combined container-syringe 1 has a cylindrical cylinder 7 that is filled with a drug solution and an injection needle is mounted on the front end thereof; an engagement portion 13 that is provided at the front end side of the cylinder; a finger grip 9 that is provided on the rear end side of the cylinder 7; and a cylindrical-shaped safety device 3 that is mounted in a slidable manner on the outer periphery of the cylinder 7, and covers all the sphere of the injection needle 10 when it has moved in the front end direction. Furthermore, a return prevention stopper 27 which flexes inward in the radial direction by a pressing ring 5 and prevents the movement of the safety device 3 in the rear end direction by engaging with the engagement portion 13, and a slip-out prevention stopper 25 which prevents the movement of the safety device 3 in the front end direction, by engaging with the engagement portion 13.
    Type: Application
    Filed: April 24, 2008
    Publication date: May 27, 2010
    Inventor: Makoto Kakiuchi
  • Publication number: 20090036837
    Abstract: The present invention relates to a combined container-syringe including: a cylindrical cylinder filled with a drug solution; a cylindrical tip provided at the cylinder; an injection needle mounted on the cylindrical tip; a finger grip provided on the cylinder; a cylindrical-shaped safety device that is mounted in a slidable manner on the outer periphery of the cylinder and covers the injection needle when it has moved in the front end direction; a retaining member that selectively engages the safety device at a first position that is away from the injection needle and a second position that covers the injection needle; and a coil spring that biases the safety device in the direction of the second position. According to the present invention, it is possible to reliably cover the injection needle by causing the safety device to move with respect to the syringe body and so possible to ensure safety.
    Type: Application
    Filed: July 31, 2008
    Publication date: February 5, 2009
    Applicant: ARTE CORPORATION
    Inventor: Makoto Kakiuchi