Patents by Inventor Makoto Kakutani

Makoto Kakutani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC OR PROPHYLACTIC AGENT FOR CHRONIC KIDNEY DISEASE CONTAINING PYRAZOLE-AMIDE COMPOUND
    Publication number: 20220362215
    Abstract: The present invention aims to provide novel pharmaceutical use of compound A or a pharmaceutically acceptable salt thereof, or a monohydrate of compound A. The present invention relates to a therapeutic or prophylactic agent for chronic kidney diseases containing compound A or a pharmaceutically acceptable salt thereof, or a monohydrate of compound A as the active ingredient.
    Type: Application
    Filed: September 10, 2019
    Publication date: November 17, 2022
    Inventors: Tomoyuki SAITO, Takeshi OHTA, Makoto KAKUTANI, Yasuko MERA
  • Triazole compounds and uses related thereto
    Patent number: 8153631
    Abstract: The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound has superior HSD1 inhibitory activity, and is useful as an HSD1 inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity or a therapeutic drug of metabolic syndrome.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: April 10, 2012
    Assignee: Amgen Inc.
    Inventors: Jay P. Powers, Mario G. Cardozo, Hiroyuki Goto, Kazuhito Harada, Katsuaki Imamura, Makoto Kakutani, Isamu Matsuda, Yasuhiro Ohe, Shinji Yata
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20110245223
    Abstract: The present invention provides a compound represented by the following formula [1?] or a salt thereof: wherein ring A, R2, R3, R4 and X are as defined in the description, and an agent for the treatment or prophylaxis of a pathology involving glucocorticoid, or a 11?HSD1 inhibitor, containing the compound or a salt thereof.
    Type: Application
    Filed: December 1, 2010
    Publication date: October 6, 2011
    Applicant: Japan Tobacco Inc.
    Inventors: Hiroshi Yamamoto, Yasuhiro Ohe, Hiroyuki Goto, Kazuhito Harada, Shinji Yata, Takashi Ito, Jun Nishiu, Makoto Kakutani, Shunsuke Fujii, Kota Asahina
  • Arylsulfones and uses related thereto
    Patent number: 7754890
    Abstract: Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: July 13, 2010
    Assignee: Amgen Inc.
    Inventors: Pingchen Fan, Hiroyuki Goto, Xiao He, Makoto Kakutani, Marc Labelle, Dustin L. McMinn, Jay P. Powers, Yosup Rew, Daqing Sun, Xuelei Yan
  • Triazole compounds and uses related thereto
    Patent number: 7683059
    Abstract: The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.
    Type: Grant
    Filed: September 5, 2006
    Date of Patent: March 23, 2010
    Assignee: Amgen Inc.
    Inventors: Mario G. Cardozo, Jay P. Powers, Hiroyuki Goto, Kazuhito Harada, Katsuaki Imamura, Makoto Kakutani, Isamu Matsuda, Yasuhiro Ohe, Shinji Yata
  • TRIAZOLE COMPOUNDS AND USES RELATED THERETO
    Publication number: 20100062972
    Abstract: The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound has superior HSD1 inhibitory activity, and is useful as an HSD1 inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity or a therapeutic drug of metabolic syndrome.
    Type: Application
    Filed: November 19, 2009
    Publication date: March 11, 2010
    Inventors: JAY P. POWERS, Mario G. CARDOZO, Hiroyuki GOTO, Kazuhito HARADA, Katsuaki IMAMURA, Makoto KAKUTANI, Isamu MATSUDA, Yasuhiro OHE, Shinji YATA
  • Triazole Compounds and Uses Related Thereto
    Publication number: 20080249084
    Abstract: The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.
    Type: Application
    Filed: October 27, 2004
    Publication date: October 9, 2008
    Inventors: Jay P. Powers, Mario G. Cardozo, Hiroyuki Goto, Kazuhito Harada, Katsuaki Imamura, Makoto Kakutani, Isamu Matsuda, Yasuhiro Ohe, Shinji Yata
  • Arylsulfones and uses related thereto
    Patent number: 7402704
    Abstract: Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: July 22, 2008
    Assignee: Amgen Inc.
    Inventors: Pingchen Fan, Hiroyuki Goto, Xiao He, Makoto Kakutani, Marc Labelle, Dustin L. McMinn, Jay P. Powers, Yosup Rew, Daqing Sun, Xuelei Yan
  • Pyrazole compounds and uses related thereto
    Publication number: 20080161374
    Abstract: Substituted pyrazoles are provided that are useful for the treatment of, for example, diabetes, obesity and metabolic syndrome.
    Type: Application
    Filed: February 14, 2008
    Publication date: July 3, 2008
    Inventors: Hiroyuki Goto, Makoto Kakutani, Jun Nishiu, Yasuhiro Ohe, Jay P. Powers, Shinji Yata, Hua Tu
  • Pyrazole compounds and uses related thereto
    Patent number: 7354938
    Abstract: Substituted pyrazoles are provided that are useful for the treatment of, for example, diabetes, obesity and metabolic syndrome.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: April 8, 2008
    Assignee: Amgen Inc.
    Inventors: Hiroyuki Goto, Makoto Kakutani, Jun Nishiu, Yasuhiro Ohe, Jay P. Powers, Shinji Yata, Hua Tu
  • Heterocyclic compounds
    Publication number: 20070072908
    Abstract: The present invention provides a compound represented by the following formula [1?] or a salt thereof: wherein ring A, R2, R3, R4 and X are as defined in the description, and an agent for the treatment or prophylaxis of a pathology involving glucocorticoid, or a 11?HSD1 inhibitor, containing the compound or a salt thereof.
    Type: Application
    Filed: June 8, 2006
    Publication date: March 29, 2007
    Applicant: JAPAN TOBACCO INC.
    Inventors: Hiroshi Yamamoto, Yasuhiro Ohe, Hiroyuki Goto, Kazuhito Harada, Shinji Yata, Takashi Ito, Jun Nishiu, Makoto Kakutani, Shunsuke Fujii, Kota Asahina
  • Arylsulfones and uses related thereto
    Publication number: 20050277665
    Abstract: Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
    Type: Application
    Filed: April 14, 2005
    Publication date: December 15, 2005
    Inventors: Pingchen Fan, Hiroyuki Goto, Xiao He, Makoto Kakutani, Marc Labelle, Dustin McMinn, Jay Powers, Yosup Rew, Daqing Sun, Xuelei Yan
  • Pyrazole compounds and uses related thereto
    Publication number: 20050272793
    Abstract: Substituted pyrazoles are provided that are useful for the treatment of, for example, diabetes, obesity and metabolic syndrome.
    Type: Application
    Filed: March 18, 2005
    Publication date: December 8, 2005
    Applicant: Amgen Inc.
    Inventors: Hiroyuki Goto, Makoto Kakutani, Jun Nishiu, Yasuhiro Ohe, Jay Powers, Shinji Yata