Patents by Inventor Makoto Kanebako
Makoto Kanebako has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220047585Abstract: A preventing or treating agent for glaucoma is provided. This drug has a strong action of reducing intraocular pressure such that the intraocular pressure can be reduced even from the normal intraocular pressure. More specifically, a prophylactic or therapeutic agent for glaucoma, a preventing or treating agent for ocular hypertension, and eye drops containing (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl homopiperazine or its salt and phosphoric acid or its salt are provided.Type: ApplicationFiled: November 1, 2021Publication date: February 17, 2022Applicant: KOWA CO., LTD.Inventors: Shin SUGIMOTO, Ken MIZUNO, Masatoshi TAKAHASHI, Makoto KANEBAKO
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Publication number: 20190328730Abstract: A preventing or treating agent for glaucoma is provided. This drug has a strong action of reducing intraocular pressure such that the intraocular pressure can be reduced even from the normal intraocular pressure. More specifically, a prophylactic or therapeutic agent for glaucoma, a preventing or treating agent for ocular hypertension, and eye drops containing (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl homopiperazine or its salt and phosphoric acid or its salt are provided.Type: ApplicationFiled: July 8, 2019Publication date: October 31, 2019Applicant: KOWA CO., LTD.Inventors: Shin SUGIMOTO, Ken MIZUNO, Masatoshi TAKAHASHI, Makoto KANEBAKO
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Patent number: 8673960Abstract: The present invention provides an indomethacin-containing external liquid preparation which provides good feeling of use, which exhibits high percutaneous absorption of indomethacin, and which, particularly in a low-temperature environment, does not cause precipitation of crystals with time. The present invention is drawn to an external liquid preparation containing indomethacin, a lower alcohol, water, a sulfite, and polyethylene glycol having an average molecular weight of 3,000 to 15,000.Type: GrantFiled: October 16, 2006Date of Patent: March 18, 2014Assignee: Kowa Co., Ltd.Inventors: Hiroshi Miura, Makoto Kanebako
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Patent number: 8442629Abstract: Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis. An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.Type: GrantFiled: April 17, 2009Date of Patent: May 14, 2013Assignee: Kowa Co., Ltd.Inventors: Kenichi Suzuki, Makoto Kanebako, Toshio Inagi
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Patent number: 8362027Abstract: The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.Type: GrantFiled: August 8, 2011Date of Patent: January 29, 2013Assignees: Kowa Co., Ltd., Tokyo University of Science Educational Foundation Administrative OrganizationInventors: Toshio Inagi, Makoto Kanebako, Hiroshi Terada, Kimiko Makino, Masakazu Toi
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Patent number: 8105630Abstract: A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2?) corresponding to a d value of at least 1 nm. The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.Type: GrantFiled: April 28, 2004Date of Patent: January 31, 2012Assignees: Kowa Co., Ltd., Kabushiki Kaisha Toyota Chuo KenkyushoInventors: Hiroshi Miura, Makoto Kanebako, Masayuki Kanishi, Toshio Inagi, Hirofumi Takeuchi, Tsutomu Kajino, Yoshiaki Fukushima, Haruo Takahashi
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Patent number: 8101207Abstract: A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2?) corresponding to d of 1 nm or more); and a method for producing the composition. The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.Type: GrantFiled: April 28, 2004Date of Patent: January 24, 2012Assignee: Kowa Co., Ltd.Inventors: Hiroshi Miura, Makoto Kanebako, Masayuki Kanishi, Yasuo Shinoda, Toshio Inagi, Hirofumi Takeuchi
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Patent number: 8097275Abstract: An object of the invention is to provide a hydrous external skin patch, which has adherence sufficient for adhering to an affected area for several times without using an auxiliary tape or the like and is excellent in utility so that the patch can be easily peeled off even if the paste adheres to itself before application to the affected area. The hydrous external skin patch is characterized in that a paste of the patch comprises 0.1 to 10 wt % of a drug, 0.1 to 20 wt % of an adhesive base, 0.001 to 3.0 wt % of a crosslinker, 15 to 60 wt % of water, 2 to 20 wt % of a tackifier resin, 0.4 to 10 wt % of a dissolving agent for the tackifier resin, 0.1 to 30 wt % of an oil absorbing inorganic powder, and 0.1 to 20 wt % of a dextrin fatty acid ester and has a thickness of 100 to 1,000 ?m.Type: GrantFiled: April 23, 2009Date of Patent: January 17, 2012Assignees: Kowa Company, Ltd., Maeda Pharmaceutical Co., Ltd.Inventors: Makoto Kanebako, Gou Yanagimoto, Toru Watanabe, Shouichi Hasegawa
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Publication number: 20120004305Abstract: An external preparation containing the following components (A), (B), (C), and (D): (A) a non-steroidal analgesic/anti-inflammatory agent, (B) a terpene and/or an essential oil containing a terpene, (C) a higher alcohol, and (D) a polyoxyalkylene alkyl ether and/or a polyoxyalkylene alkenyl ether. The external preparation of the present invention has improved skin permeation, and can thus be effective at a low concentration, and also has excellent appearance.Type: ApplicationFiled: March 11, 2010Publication date: January 5, 2012Applicant: Kowa Co., Ltd.Inventors: Seiji Miura, Makoto Kanebako
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Publication number: 20110295189Abstract: The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.Type: ApplicationFiled: August 8, 2011Publication date: December 1, 2011Applicants: Tokyo Univ. of Sci. Edu. Fdn. Admin. Org., Kowa Co., Ltd.Inventors: Toshio INAGI, Makoto Kanebako, Hiroshi Terada, Kimiko Makino, Masakazu Toi
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Patent number: 8034824Abstract: The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.Type: GrantFiled: October 11, 2006Date of Patent: October 11, 2011Assignees: Kowa Co., Ltd., Tokyo University of Science Educational Foundation Administrative OrganizationInventors: Toshio Inagi, Makoto Kanebako, Hiroshi Terada, Kimiko Makino, Masakazu Toi
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Publication number: 20110034859Abstract: Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis. An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.Type: ApplicationFiled: April 17, 2009Publication date: February 10, 2011Applicants: Tokyo University of Sci Edu Found Admin Org, TAIHO PHARMACEUTICAL CO., LTD.Inventors: Kenichi Suzuki, Makoto Kanebako, Toshio Inagi
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Publication number: 20100233287Abstract: A preventing or treating agent for glaucoma is provided. This drug has a strong action of reducing intraocular pressure such that the intraocular pressure can be reduced even from the normal intraocular pressure. More specifically, a prophylactic or therapeutic agent for glaucoma, a preventing or treating agent for ocular hypertension, and eye drops containing (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl homopiperazine or its salt and phosphoric acid or its salt are provided.Type: ApplicationFiled: May 24, 2010Publication date: September 16, 2010Applicant: Kowa Co., Ltd.Inventors: Shin Sugimoto, Ken Mizuno, Masatoshi Takahashi, Makoto Kanebako
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Publication number: 20100003312Abstract: An object of the invention is to provide a hydrous external skin patch, which has adherence sufficient for adhering to an affected area for several times without using an auxiliary tape or the like and is excellent in utility so that the patch can be easily peeled off even if the paste adheres to itself before application to the affected area. The hydrous external skin patch is characterized in that a paste of the patch comprises 0.1 to 10 wt % of a drug, 0.1 to 20 wt % of an adhesive base, 0.001 to 3.0 wt % of a crosslinker, 15 to 60 wt % of water, 2 to 20 wt % of a tackifier resin, 0.4 to 10 wt % of a dissolving agent for the tackifier resin, 0.1 to 30 wt % of an oil absorbing inorganic powder, and 0.1 to 20 wt % of a dextrin fatty acid ester and has a thickness of 100 to 1,000 ?m.Type: ApplicationFiled: April 23, 2009Publication date: January 7, 2010Applicants: Kowa Company, Ltd., Maeda Pharmaceutical Co., Ltd.Inventors: Makoto Kanebako, Gou Yanagimoto, Toru Watanabe, Shouichi Hasegawa
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Publication number: 20090281063Abstract: The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.Type: ApplicationFiled: October 11, 2006Publication date: November 12, 2009Applicants: KOWA CO., LTD., TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATIONInventors: Toshio Inagi, Makoto Kanebako, Hiroshi Terada, Kimiko Makino, Masakazu Toi
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Publication number: 20090137657Abstract: The present invention provides an indomethacin-containing external liquid preparation which provides good feeling of use, which exhibits high percutaneous absorption of indomethacin, and which, particularly in a low-temperature environment, does not cause precipitation of crystals with time. The present invention is drawn to an external liquid preparation containing indomethacin, a lower alcohol, water, a sulfite, and polyethylene glycol having an average molecular weight of 3,000 to 15,000.Type: ApplicationFiled: October 16, 2006Publication date: May 28, 2009Applicant: Kowa Co., LtdInventors: Hiroshi Miura, Makoto Kanebako
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Publication number: 20070166360Abstract: An external preparation comprising following ingredients (A) and (B): (A) a compound represented by the following general formula (1) wherein R1 represents an organic residue having a cyclic structure that may have a substituent; R2 represents a hydrogen atom or a lower alkyl group; and X represents an ethylene group or an ethenylene group or a salt thereof, and (B) a monoterpene. The external preparation of the present invention is excellent in percutaneous absorbability.Type: ApplicationFiled: March 30, 2005Publication date: July 19, 2007Applicants: Kowa Co., Ltd., Nissan Chemical Industries, Ltd.Inventors: Tatsuya Nakai, Makoto Kanebako
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Publication number: 20070128273Abstract: A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2?) corresponding to d of 1 nm or more); and a method for producing the composition. The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.Type: ApplicationFiled: April 28, 2004Publication date: June 7, 2007Applicant: Kowa Co., Ltd.Inventors: Hiroshi Miura, Makoto Kanebako, Masayuki Kanishi, Yasuo Shinoda, Toshio Inagi, Hirofumi Takeuchi
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Publication number: 20060293327Abstract: A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2?) corresponding to a d value of at least 1 nm. The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.Type: ApplicationFiled: April 28, 2004Publication date: December 28, 2006Applicants: Kowa Co. Ltd., KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHOInventors: Hiroshi Miura, Makoto Kanebako, Masayuki Kanishi, Toshio Inagi, Hirofumi Takeuichi, Tsutomu Kajino, Yoshiaki Fukushima, Haruo Takahashi
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Publication number: 20060142270Abstract: A preventing or treating agent for glaucoma is provided. This drug has a strong action of reducing intraocular pressure such that the intraocular pressure can be reduced even from the normal intraocular pressure. More specifically, a prophylactic or therapeutic agent for glaucoma, a preventing or treating agent for ocular hypertension, and eye drops containing (S)-(-)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl homopiperazine or its salt and phosphoric acid or its salt are provided.Type: ApplicationFiled: December 14, 2005Publication date: June 29, 2006Applicant: Kowa Co., Ltd.Inventors: Shin Sugimoto, Ken Mizuno, Masatoshi Takahashi, Makoto Kanebako