Patents by Inventor Makoto Makishima

Makoto Makishima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition for the treatment of leukemia containing 9-cis-retinoic acid-.alpha.-tocopherol ester
    Patent number: 5827878
    Abstract: 9-Cis-retinoic acid-.alpha.-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia are provided and a combined use of a 9-cis-retinoic acid-.alpha.-tocopherol ester and either 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid exhibits a synergistic effect in the treatment of leukemia without any side effects caused by 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: October 27, 1998
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Makoto Makishima, Yasuhiro Kanatani, Yoshio Honma, Kohei Inomata, Takao Kishiye