Patents by Inventor Makoto Matsui

Makoto Matsui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240100022
    Abstract: The present invention relates to an oral solid dosage form comprising N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alaninamide, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof as an active ingredient, which has good dissolution and storage-stability. When the oral solid dosage form is a tablet, the tablet can be prepared while inhibiting tableting troubles from low content to high content of the active ingredient.
    Type: Application
    Filed: December 22, 2021
    Publication date: March 28, 2024
    Applicants: SUMITOMO PHARMA CO., LTD., ALPHANAVI PHARMA INC.
    Inventors: Hiroki IKARI, Yuka KATO, Makoto MATSUOKA, Yasuhiro MATSUI, Megumi MARUYAMA
  • Publication number: 20240053540
    Abstract: A light guide plate includes a glass substrate having a mark on a surface thereof and a refractive index of 1.7 or more. The mark includes a plurality of dots. Each dot is contained in a minimum circle having a diameter of 30 to 250 ?m. Each dot has raised portions higher than the surface at outermost and innermost peripheral edge portions having a height of 0.11 to 4 ?m. Each dot is composed of laser irradiation marks, each having a diameter of 10 to 40 ?m, and being in contact with or overlapping with each other. A specific loop shape, formed by the laser irradiation marks, having a diameter of a minimum circle containing the loop shape of 100 ?m or less, is configured as an open loop including an open portion having a length of one tenth to twice of a maximum diameter of the laser irradiation mark.
    Type: Application
    Filed: October 23, 2023
    Publication date: February 15, 2024
    Applicant: AGC Inc.
    Inventors: Makoto MATSUI, Kunihisa TAKAHASHI
  • Patent number: 11890347
    Abstract: A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: February 6, 2024
    Assignee: Tokyo Institute of Technology
    Inventors: Nobuhiro Nishiyama, Hiroyasu Takemoto, Abdul-Hackam Ranneh, Keishiro Tomoda, Takahiro Nomoto, Makoto Matsui
  • Patent number: 11707530
    Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: July 25, 2023
    Assignees: TOKYO INSTITUTE OF TECHNOLOGY, OSAKA UNIVERSITY
    Inventors: Nobuhiro Nishiyama, Hiroyasu Takemoto, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Naoki Yamada, Yuto Honda, Hideshi Ishii, Masaki Mori, Masamitsu Konno
  • Patent number: 11555082
    Abstract: The present invention pertains to: a p-boronophenylalanine derivative that comprises a polymer to which a group represented by formula (I) is linked directly or via a linker; a composition containing same; and a kit for producing said derivative and composition.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: January 17, 2023
    Assignee: TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Nobuhiro Nishiyama, Takahiro Nomoto, Yukiya Inoue, Ying Yao, Kaito Kanamori, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda
  • Publication number: 20220387609
    Abstract: A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A): wherein each symbol is as defined in the present specification, is provided by the present invention.
    Type: Application
    Filed: March 26, 2020
    Publication date: December 8, 2022
    Applicants: NOF CORPORATION, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Hiroki YOSHIOKA, Kazuki OSAKAMA, Mika HAMURA, Takanori INABA, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Takahiro NOMOTO, Xiaohang SUN
  • Publication number: 20220265836
    Abstract: A complex is provided comprising a conjugate in which a polymer having a boronic acid group and a compound having a diol structure are bonded, and a substance that is complexed with the conjugate.
    Type: Application
    Filed: May 29, 2020
    Publication date: August 25, 2022
    Applicants: TOKYO INSTITUTE OF TECHNOLOGY, KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Nobuhiro Nishiyama, Yuto Honda, Takahiro Nomoto, Hiroyasu Takemoto, Makoto Matsui, Hiroaki Kinoh, Kazunori Kataoka, Xueying Liu, Anjaneyulu Dirisala
  • Publication number: 20220211646
    Abstract: A conjugate is provided in which a deferoxamine-type compound, which is at least one compound selected from the group consisting of deferoxamine or an ion or salt thereof, and a derivative thereof, and a biocompatible polymer are conjugated, where the biocompatible polymer contains a first biocompatible polymer chain and a second biocompatible polymer chain that is different from the first biocompatible polymer chain.
    Type: Application
    Filed: April 23, 2020
    Publication date: July 7, 2022
    Inventors: Nobuhiro NISHIYAMA, Takahiro NOMOTO, Kana KOHMOTO, Hiroyasu TAKEMOTO, Makoto MATSUI
  • Patent number: 11376266
    Abstract: The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: July 5, 2022
    Assignees: Keio University, Tokyo Institute of Technology
    Inventors: Hideyuki Saya, Osamu Nagano, Kenji Tsuchihashi, Kentaro Suina, Nobuhiro Nishiyama, Hiroyasu Takemoto, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Naoki Yamada, Tsukasa Nishimori
  • Publication number: 20220153992
    Abstract: An intracellularly degraded branched and degradable polyethylene glycol derivative represented by the following formula (1): wherein each symbol is as defined in the present specification, that is used for modifying bio-related substances is provided by the present invention.
    Type: Application
    Filed: March 26, 2020
    Publication date: May 19, 2022
    Applicants: NOF CORPORATION, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Hiroki YOSHIOKA, Kazuki OSAKAMA, Mika HAMURA, Takanori INABA, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Takahiro NOMOTO, Xiaohang SUN
  • Publication number: 20210308271
    Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.
    Type: Application
    Filed: August 17, 2017
    Publication date: October 7, 2021
    Applicants: TOKYO INSTITUTE OF TECHNOLOGY, OSAKA UNIVERISTY
    Inventors: Nobuhiro Nishiyama, Hiroyasu Takemoto, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Naoki Yamada, Yuto Honda, Hideshi Ishii, Masaki Mori, Masamitsu Konno
  • Publication number: 20210147624
    Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.
    Type: Application
    Filed: March 29, 2019
    Publication date: May 20, 2021
    Applicants: NOF Corporation, Tokyo Institute of Technology
    Inventors: Hiroki YOSHIOKA, Masaki KAMIYA, Yuji YAMAMOTO, Midori HIRAI, Akiko SASAKI, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Kazuki MIYAUCHI, Takahiro NOMOTO, Keishiro TOMODA
  • Publication number: 20210040244
    Abstract: The present invention pertains to: a p-boronophenylalanine derivative that comprises a polymer to which a group represented by formula (I) is linked directly or via a linker; a composition containing same; and a kit for producing said derivative and composition.
    Type: Application
    Filed: February 19, 2019
    Publication date: February 11, 2021
    Inventors: Nobuhiro NISHIYAMA, Takahiro NOMOTO, Yukiya INOUE, Ying YAO, Kaito KANAMORI, Hiroyasu TAKEMOTO, Makoto MATSUI, Keishiro TOMODA
  • Publication number: 20210023231
    Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 28, 2021
    Applicants: NOF CORPORATION, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Hiroki YOSHIOKA, Masaki KAMIYA, Yuji YAMAMOTO, Midori HIRAI, Akiko SASAKI, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Kazuki MIYAUCHI, Takahiro NOMOTO, Keishiro TOMODA
  • Publication number: 20200261476
    Abstract: The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.
    Type: Application
    Filed: January 5, 2017
    Publication date: August 20, 2020
    Applicants: KEIO UNIVERSITY, TOKYO INSTITUTE OF TECHNOLOGY, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Hideyuki SAYA, Osamu NAGANO, Kenji TSUCHIHASHI, Kentaro SUINA, Nobuhiro NISHIYAMA, Hiroyasu TAKEMOTO, Takahiro NOMOTO, Makoto MATSUI, Keishiro TOMODA, Naoki YAMADA, Tsukasa NISHIMORI
  • Publication number: 20200069807
    Abstract: A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.
    Type: Application
    Filed: December 5, 2017
    Publication date: March 5, 2020
    Inventors: Nobuhiro Nishiyama, Hiroyasu Takemoto, Abdul-Hackam Ranneh, Keishiro Tomoda, Takahiro Nomoto, Makoto Matsui
  • Publication number: 20190098151
    Abstract: An information processing apparatus comprises a touch panel and a frequency change control section. The touch panel is an electrostatic capacity type touch panel. The frequency change control section changes a scan frequency of the touch panel.
    Type: Application
    Filed: September 25, 2017
    Publication date: March 28, 2019
    Inventor: Makoto Matsui
  • Patent number: 9617620
    Abstract: An alumina- or magnesia-reducing process in which a greenhouse gas or substance harmful to the human body is not emitted, which can achieve improved energy efficiency in comparison with the Hall-Heroult or Pidgeon methods. The process includes: introducing an alumina or magnesia powder with a carrier gas to the upstream side of a throat provided on a reducing unit; pressure-transferring the powder and carrier gas to the throat by an operative gas introduced to the upstream side of the throat; irradiating the throat with a laser beam to convert the alumina or magnesia into a plasma state and dissociate the alumina or magnesia thermally; jetting the thermally dissociated product through a nozzle provided on the downstream side of the throat at a supersonic speed to form a frozen flow; and isolating aluminum or magnesium. Hydrogen may be added to the operative gas to accelerate the reduction of alumina or magnesia.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: April 11, 2017
    Inventors: Yoshihiro Arakawa, Masakatsu Nakano, Makoto Matsui, Tetsuya Goto
  • Publication number: 20150226425
    Abstract: A method to provide renewable energy by utilizing aluminum, which is easy to store and stably suppliable, as a fuel without harming the environment or human body. Aluminum powder and oxygen are introduced into a combustion chamber and subjected to stationary combustion. The stationary combustion of aluminum is conducted by controlling either or both amounts of aluminum powder and oxygen introduced into the chamber. The amount of the aluminum powder is controlled by the amount of aluminum powder sucked into a jet stream of a carrier gas that introduces the powder into the combustion chamber, or by the amount of an impurity to be mixed with the powder. The amount of oxygen is controlled by the mixing ratio of oxygen to a diluent gas introduced simultaneously. The alumina from the combustion is recovered, reduced to aluminum, and recycled as a fuel.
    Type: Application
    Filed: March 8, 2013
    Publication date: August 13, 2015
    Inventors: Tetsuya Goto, Yoshihiro Arakawa, Shuhei Takahashi, Masakatsu Nakano, Makoto Matsui
  • Publication number: 20150203937
    Abstract: An alumina- or magnesia-reducing process in which a greenhouse gas or substance harmful to the human body is not emitted, which can achieve improved energy efficiency in comparison with the Hall-Heroult or Pidgeon methods. The process includes: introducing an alumina or magnesia powder with a carrier gas to the upstream side of a throat provided on a reducing unit; pressure-transferring the powder and carrier gas to the throat by an operative gas introduced to the upstream side of the throat; irradiating the throat with a laser beam to convert the alumina or magnesia into a plasma state and dissociate the alumina or magnesia thermally; jetting the thermally dissociated product through a nozzle provided on the downstream side of the throat at a supersonic speed to form a frozen flow; and isolating aluminum or magnesium. Hydrogen may be added to the operative gas to accelerate the reduction of alumina or magnesia.
    Type: Application
    Filed: March 8, 2013
    Publication date: July 23, 2015
    Inventors: Yoshihiro Arakawa, Masakatsu Nakano, Makoto Matsui, Tetsuya Goto