Abstract: Provided is an automatic analysis device and an analysis method which are capable of reliably detecting an abnormality in a dispensing amount of a solution such as a specimen or a reagent to be dispensed and suppressing a decrease in analysis accuracy.

Abstract: The method for controlling a liquid chromatograph according to the invention is a method for controlling the liquid chromatograph including a liquid delivery pump, a flow path connected to the liquid delivery pump, a flow path switching valve (an auto purge valve, an injection valve, and a stream select valve) provided in the flow path and configured to switch a plurality of connection destinations for the flow path, and a pressure sensor configured to detect at least one of a liquid delivery pressure of the liquid delivery pump, a flow path pressure in the flow path, and a pressure applied to the flow path switching valve. The method includes rotating the flow path switching valve during liquid delivery from the liquid delivery pump, and determining whether a bubble remains in the flow path based on a pressure fluctuation when the pressure lowered by rotating the flow path switching valve increases.

Abstract: An automatic analyzer is provided that is capable of quickly responding when an abnormal process occurs, accurately grasping an abnormal state, and reducing frequencies of early abnormality diagnosis and component adjustment or replacement of the automatic analyzer. The automatic analyzer compares data output information with reference data output information, applies a data alarm to an item of the data output information determined to be in an abnormal state, compares system output information with reference system output information, applies a data alarm to an item of a data output information determined to be in an abnormal state, and executes a predictive diagnosis of a failure state of the automatic analyzer based on a temporal change of the data output information obtained by the analyzer using an internal standard substance as a sample and a temporal change of the system output information.

Abstract: Implemented is an analysis apparatus column oven equipped with a plurality of columns, which is capable of efficiently performing heat conduction on column basis, recognizing a column cartridge that holds a column, and being easily exchanged on column basis. The column change mechanism includes the ferrule, the movable ferrule connector, the pipe, the fastener pull, the fastener fitting, the column cartridge presser, the slide guide, the RFID reader, the fixed wall, the column changer heat insulating member, the fixed bottom plate, the receiver, and the fixed fitting. A plurality of column cartridges can be installed in the heat block, and are in contact with the column heat block to control the temperature in the column cartridges. The column cartridge is fixed between left and right column change mechanisms, and when the fixed column cartridge is opened, the column change mechanism on the left side is moved leftward and opened.

Abstract: Provided is an automatic analysis device and an analysis method which are capable of reliably detecting an abnormality in a dispensing amount of a solution such as a specimen or a reagent to be dispensed and suppressing a decrease in analysis accuracy.

Abstract: An analysis apparatus capable of adjusting holding time of each stream in a plurality of HPLC streams without adjusting a pipe length, and capable of determining degradation of a separation column, a liquid-delivery failure, or the like without removing a pipe from the apparatus is implemented. Air is suctioned from the shipper 109 and injected into the verification flow paths 122 and 123, and holding time when a baseline of the detector 125 changes is stored in the control unit 130. The air in the verification flow paths 122 and 123 of the stream 101 and the stream 102 is measured, and holding time of the stream 101 and holding time of the stream 102 are compared to determine whether or not there is a difference of 1 second or more in the holding time. When the difference in holding time is 1 second or more, correction is performed.

Abstract: An analysis apparatus column oven equipped with a plurality of columns is capable of efficiently performing heat conduction on column basis, recognizing a column cartridge that holds a column, and being easily exchanged on column basis. The column change mechanism includes a ferrule, a movable ferrule connector, a pipe, a fastener pull, a fastener fitting, a column cartridge presser, a slide guide, an RFID reader, a fixed wall, a column changer heat insulating member, a fixed bottom plate, a receiver, and a fixed fitting. A plurality of column cartridges can be installed in the heat block, and are in contact with the column heat block to control the temperature in the column cartridges. The column cartridge is fixed between left and right column change mechanisms, and when the fixed column cartridge is opened, the column change mechanism on the left side is moved leftward and opened.

Abstract: An automatic analyzer includes a liquid feed unit including a liquid feed unit and a liquid feed flow passage and feeding a mobile phase, a sample introduction unit introducing a sample to the mobile phase, a separation column separating the sample into plural components, a detector detecting the component, and a control unit. A pressure sensor detecting pressure of the liquid feed flow passage is provided, and the control unit calculates a pressure rise rate of the time immediately after starting liquid feeding of the mobile phase based on the pressure detected by the pressure sensor and a compression pressure variation amount and a pressure average after continuing liquid feeding of the mobile phase for a certain time, and determines completion of equilibration of the separation column.

Abstract: The present invention makes it possible to realize an analysis apparatus having a plurality of liquid chromatographs capable of judging separation performance and the like at the right timing and improving analysis performance early. Analysis starts and a mixed sample is prepared by adding a non-retaining ingredient to a measurement object sample and is introduced into an analysis flow path (S401 to S404). The mixed sample is separated into components by a separation column, the components are outputted as chromatogram data by a detector, and the analysis finishes (S404 to S406). Retention time and peak information are acquired from the chromatogram outputted from the detector, whether or not a measurement result is within an allowable range is judged, and the process shifts to next analysis when the measurement result is within the allowable range (S407 to S409).

Abstract: The analysis apparatus includes a standby section which is provided between a dispensing operation of an analysis item B? prior to an analysis item C and the sample analysis channel introduction. The sample analysis channel introduction is arranged prior to a data collection section of an analysis item A. The operation is started earlier but after a sample dispensing operation section of the analysis item A. A sample dispensing operation section of the analysis item C can be started earlier and the analysis time of the analysis item C can be moved to immediately after a sample analysis operation section of the analysis item B?. The analysis item A in a second cycle can be started earlier by the early start time of the analysis item C in a first cycle. A total processing time Tc can be shorter than a total processing time Tb.

Abstract: A control method for an automatic analyzer that can improve robustness, throughput, and measurement accuracy. The automatic analyzer includes a sample loop connected between two sample ports of a plurality of sample ports of a switch valve. The method includes the steps of: adjusting a drive parameter of the syringe corresponding to a viscosity of the sample acquired in advance; switching the switch valve to a first state in which the sipper and the syringe contact with each other without through the sample loop; driving the syringe based on the drive parameter to draw and introduce the sample through the sipper; switching the switch valve to a second state in which the syringe and the sample loop conduct with each other; and driving the syringe based on the drive parameter to introduce the sample into the sample loop.

Abstract: A pretreatment method of an automatic analyzer, in which pretreatments of a plurality of substances to be measured can be performed by a series of treatments using a plurality of magnetic beads that can bind to the plurality of substances to be measured, is achieved. In the pretreatment method of an automatic analyzer, a magnetic bead is added to a sample containing a substance to be measured, the substance to be measured is bound to the magnetic bead, the magnetic bead is extracted from the sample, and the substance to be measured is separated from the magnetic bead by an eluate. A plurality of magnetic beads that bind to a plurality of types of substances to be measured are added to a sample, and the plurality of types of substances to be measured are extracted from the magnetic bead by an eluate.

Abstract: An analysis device of the present invention is provided with a sample introduction unit that introduces a sample into a mass spectroscope; a sample condensation unit that treats the sample introduced into the device; a detection unit that analyzes the sample treated by a treatment unit; and a control unit that controls the sample introduction unit, the sample condensation unit, and the detection unit. The sample introduction unit includes a sample introduction valve, and the sample condensation unit includes an elution valve and a cleaning valve, and the cleaning valve is disposed between the sample introduction valve and the elution valve.

Abstract: Implemented is an analysis apparatus column oven equipped with a plurality of columns, which is capable of efficiently performing heat conduction on column basis, recognizing a column cartridge that holds a column, and being easily exchanged on column basis. The column change mechanism 105 includes the ferrule 206, the movable ferrule connector 207, the pipe 208, the fastener pull 209, the fastener fitting 210, the column cartridge presser 211, the slide guide 212, the RFID reader 214, the fixed wall 215, the column changer heat insulating member 216, the fixed bottom plate 217, the receiver 218, and the fixed fitting 219. A plurality of column cartridges 104 can be installed in the heat block 101, and are in contact with the column heat block 103 to control the temperature in the column cartridges 104.

Abstract: An analysis apparatus capable of adjusting holding time of each stream in a plurality of HPLC streams without adjusting a pipe length, and capable of determining degradation of a separation column, a liquid-delivery failure, or the like without removing a pipe from the apparatus is implemented. Air is suctioned from the shipper 109 and injected into the verification flow paths 122 and 123, and holding time when a baseline of the detector 125 changes is stored in the control unit 130. The air in the verification flow paths 122 and 123 of the stream 101 and the stream 102 is measured, and holding time of the stream 101 and holding time of the stream 102 are compared to determine whether or not there is a difference of 1 second or more in the holding time. When the difference in holding time is 1 second or more, correction is performed.

Abstract: Tests of channels of a system as a whole can be easily performed without adding a complicated mechanism. A liquid feeding part includes a liquid feeding channel to feed a mobile phase, a drainage channel to release pressure in the liquid feeding channel, an analysis channel that discharges the mobile phase into the sample introduction part, and a channel switching valve that selectively connects the liquid feeding channel to one of the drainage channel and the analysis channel. The channel switching valve is configured to be able to provide a tight stopper state in which the liquid feeding channel is connected to neither the analysis channel nor the drainage channel.

Abstract: An analysis apparatus having a plurality of chromatographs is provided capable of achieving suppression of a reduction in throughput even when a separation column needs to be replaced at the end of its lifespan. When estimating that a column used in a liquid chromatograph 107 reaches the end of its lifespan, a control unit calculates back time from the estimated time so that another liquid chromatograph 117 is ready for measurement at a timing when the liquid chromatograph 107 becomes unusable for the measurement. Then, the control unit starts the preparation operation of the liquid chromatograph 117. After the completion of the preparation operation, the liquid chromatograph 117 performs initialization, equilibration, standard sample injection, elution, and washing processes of a preliminary new column.

Abstract: The present invention makes it possible to realize an analysis apparatus having a plurality of liquid chromatographs capable of judging separation performance and the like at the right timing and improving analysis performance early. Analysis starts and a mixed sample is prepared by adding a non-retaining ingredient to a measurement object sample and is introduced into an analysis flow path (S401 to S404). The mixed sample is separated into components by a separation column, the components are outputted as chromatogram data by a detector, and the analysis finishes (S404 to S406). Retention time and peak information are acquired from the chromatogram outputted from the detector, whether or not a measurement result is within an allowable range is judged, and the process shifts to next analysis when the measurement result is within the allowable range (S407 to S409).

Abstract: The analysis apparatus includes a standby section which is provided between a dispensing operation of an analysis item B? prior to an analysis item C and the sample analysis channel introduction. The sample analysis channel introduction is arranged prior to a data collection section of an analysis item A. The operation is started earlier but after a sample dispensing operation section of the analysis item A. A sample dispensing operation section of the analysis item C can be started earlier and the analysis time of the analysis item C can be moved to immediately after a sample analysis operation section of the analysis item B?. The analysis item A in a second cycle can be started earlier by the early start time of the analysis item C in a first cycle. A total processing time Tc can be shorter than a total processing time Tb.

Abstract: An analysis device of the present invention is provided with a sample introduction unit that introduces a sample into a mass spectroscope; a sample condensation unit that treats the sample introduced into the device; a detection unit that analyzes the sample treated by a treatment unit; and a control unit that controls the sample introduction unit, the sample condensation unit, and the detection unit. The sample introduction unit includes a sample introduction valve, and the sample condensation unit includes an elution valve and a cleaning valve, and the cleaning valve is disposed between the sample introduction valve and the elution valve.