Patents by Inventor Makoto Sakamoto

Makoto Sakamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140191751
    Abstract: A magnetic testing method and apparatus can accurately detect a flaw by magnetizing a test object to such a degree that the object becomes magnetically saturated while solving the problems of a large magnetizing device is required when only a DC magnetic field is applied and that the test object generates heat when only an AC magnetic field is applied. A magnetic testing apparatus comprises a first magnetizing device for applying a DC bias magnetic field to a test object P in substantially parallel to the direction in which a flaw F to be detected extends, a second magnetizing device for applying an AC magnetic field to the test object P substantially perpendicularly to the direction in which the flaw F to be detected extends, and a detecting device for detecting leakage flux produced by the magnetization of the test object P accomplished by the first and second magnetizing devices.
    Type: Application
    Filed: August 15, 2012
    Publication date: July 10, 2014
    Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventors: Toshiyuki Suzuma, Yoshiyuki Nakao, Makoto Sakamoto, Yoshiuki Oota
  • Patent number: 8761444
    Abstract: An apparatus for determining a kind of a steel material includes an image pickup device 11 for imaging a spark, which is produced when the steel material 18 is ground, continuously a plurality of times; a detection device 12 for detecting an alloy spark zone, which corresponds to an alloy spark produced by the grinding of an alloying component contained in the steel material, from each of picked-up images 2 imaged by the image pickup device; a calculation device 13 for calculating the total number of alloy spark zones detected by the detection device; and a judgment device 14 for determining that the steel material consists of a low-alloy steel if the total number is not smaller than a first threshold value, and determining that the steel material consists of a carbon steel if the total number is smaller than the first threshold value.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: June 24, 2014
    Assignee: Nippon Steel & Sumitomo Metal Corporation
    Inventors: Takeo Nakata, Masami Ikeda, Kazuhiro Uchida, Makoto Sakamoto, Kenji Fujiwara
  • Patent number: 8687850
    Abstract: An apparatus 1 for determining a kind of a steel material detects a spark pixel from a color picked-up image 2 of a spark 19 produced when a steel material 18 is ground, and detects a pixel, in which the density of any one color component for judgment selected from among RGB color components is low, as a low-density pixel from the spark pixels. The apparatus 1 determines that the steel material is a steel material consisting of the high-strength steel if the ratio of the total number of low-density pixels to the total number of spark pixels is not lower than a threshold value for judgment, and determines that the steel material is a steel material consisting of the ordinary steel if the ratio is lower than the threshold value for judgment.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: April 1, 2014
    Assignee: Nippon Steel & Sumitomo Metal Corporation
    Inventors: Takeo Nakata, Masami Ikeda, Makoto Sakamoto, Kenji Fujiwara, Kazuhiro Uchida
  • Patent number: 8638091
    Abstract: A rotary eddy current flaw detection probe device has a plurality of ?-shaped eddy current flaw detection probes attached in a rotating disc for detecting flaws in all directions regardless of the flaw direction. Four ?-shaped eddy current testing probes P11 to P22 are arranged around the rotation center Ds1 of a rotating disc 111 and are embedded in the disc 111. The coil planes of detector coils Ds11 to Ds22 of the testing probes P11 to P22 are parallel with each other, and are perpendicular to the rotation plane of the rotating disc 111. The coil planes of the detector coils incline at an angle ? relative to a line Y passing through the centers Ps11 and Ps12 of the probes P11 and P12. The detector coils Dc11 and Dc12 are cumulatively connected to each other and the detector coils Dc21 and Dc22 are differentially connected to each other.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: January 28, 2014
    Assignee: Nippon Steel & Sumitomo Metal Corporation
    Inventors: Takashi Hibino, Takashi Fujimoto, Shigeki Namekata, Keisuke Komatsu, Yoshiyuki Nakao, Makoto Takata, Makoto Sakamoto
  • Publication number: 20130267565
    Abstract: The present invention provides a novel compound having an excellent antitumor effect, stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.
    Type: Application
    Filed: October 3, 2011
    Publication date: October 10, 2013
    Inventors: Takashi Nakagawa, Makoto Sakamoto, Kazuya Yamaguchi, Yuki Terauchi, Masamichi Shirakura, Yasuo Harada, Yutaka Kojima, Takumi Sumida
  • Patent number: 8551999
    Abstract: The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: October 8, 2013
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Takumi Sumida, Fujio Tabusa, Kazuo Sekiguchi, Takeshi Kodama, Koichi Yasumura, Yutaka Kojima, Masaaki Motoyama, Keisuke Miyajima, Kenji Yoshida, Keizo Kan, Makoto Sakamoto, Hideki Takasu, Takashi Nakagawa, Naoto Ohi, Yasuo Harada, Norikazu Hashimoto, Hironori Matsuyama, Masatoshi Iida, Shigekazu Fujita, Tae Fukushima
  • Patent number: 8438926
    Abstract: The present invention provides a method which allows simply, easily and accurately evaluating the fastening state of shoulder parts of a threaded joint for use as a joint of pipes or tubes, such as OCTG, during fastening or after fastening. The fastening state evaluation method for a threaded joint 100 of pipes or tubes according to the present invention is characterized in that it transmits ultrasonic surface waves from the internal surface of either one of the pin 1 and the box 2 toward the internal surface of the other one of the pin 1 and the box 2 through the shoulder parts 13, 23 of the pin 1 and the box 2, and on the basis of the transmitted wave intensity or the reflected wave intensity thereof, determines whether or not the fastening state of the threaded joint 100 is satisfactory.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: May 14, 2013
    Assignee: Nippon Steel & Sumitomo Metal Corporation
    Inventors: Ikuji Hoshino, Masaki Yamano, Makoto Sakamoto, Keiichi Nakamura, Jun Masubuchi, Kenta Sakai
  • Publication number: 20120281877
    Abstract: An apparatus 1 for determining a kind of a steel material detects a spark pixel from a color picked-up image 2 of a spark 19 produced when a steel material 18 is ground, and detects a pixel, in which the density of any one color component for judgment selected from among RGB color components is low, as a low-density pixel from the spark pixels. The apparatus 1 determines that the steel material is a steel material consisting of the high-strength steel if the ratio of the total number of low-density pixels to the total number of spark pixels is not lower than a threshold value for judgment, and determines that the steel material is a steel material consisting of the ordinary steel if the ratio is lower than the threshold value for judgment.
    Type: Application
    Filed: May 11, 2012
    Publication date: November 8, 2012
    Applicant: SUMITOMO METAL INDUSTRIES, LTD.
    Inventors: Takeo NAKATA, Masami IKEDA, Makoto SAKAMOTO, Kenji FUJIWARA, Kazuhiro UCHIDA
  • Publication number: 20120281876
    Abstract: An apparatus for determining a kind of a steel material includes an image pickup device 11 for imaging a spark, which is produced when the steel material 18 is ground, continuously a plurality of times; a detection device 12 for detecting an alloy spark zone, which corresponds to an alloy spark produced by the grinding of an alloying component contained in the steel material, from each of picked-up images 2 imaged by the image pickup device; a calculation device 13 for calculating the total number of alloy spark zones detected by the detection device; and a judgment device 14 for determining that the steel material consists of a low-alloy steel if the total number is not smaller than a first threshold value, and determining that the steel material consists of a carbon steel if the total number is smaller than the first threshold value.
    Type: Application
    Filed: May 11, 2012
    Publication date: November 8, 2012
    Applicant: SUMITOMO METAL INDUSTRIES, LTD.
    Inventors: Takeo NAKATA, Masami Ikeda, Kazuhiro Uchida, Makoto Sakamoto, Kenji Fujiwara
  • Publication number: 20120238750
    Abstract: The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
    Type: Application
    Filed: February 29, 2012
    Publication date: September 20, 2012
    Inventors: Tae FUKUSHIMA, Shuji Matsumura, Noriaki Takemura, Hideaki Satou, Nobuaki Ito, Takuya Shitsuta, Hironori Tsutsui, Michinori Tanaka, Keizo Kan, Hitoshi Nagao, Kenji Watanabe, Kuninori Tai, Takashi Nakagawa, Hideki Takasu, Makoto Sakamoto, Keisuke Miyajima, Satoshi Yamada, Yutaka Kojima, Koichi Yasumura, Naoto Ohi, Mitsuhiro Okuno, Kazuhisa Sugiyama, Kunihiko Kiyono, Takashi Suzuki, Seiji Akamatsu, Takeshi Kodama, Yasuo Yanagihara, Takumi Sumida
  • Patent number: 8236826
    Abstract: An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: August 7, 2012
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Hironori Matsuyama, Kenji Ohnishi, Takashi Nakagawa, Hideki Takasu, Makoto Sakamoto, Kumi Higuchi, Keisuke Miyajima, Satoshi Yamada, Masaaki Motoyama, Yutaka Kojima, Koichi Yasumura, Takeshi Kodama, Shun Otsuji, Keizo Kan, Takumi Sumida
  • Publication number: 20120161758
    Abstract: In an eddy current testing method which involves using a rotatable eddy current testing probe in which a detection coil is arranged within an exciting coil, a change in detection sensitivity (a deviation of detection sensitivity) which changes depending on the rotational position of the detection coil is reduced. The eddy current testing probe includes an exciting coil EC1, a detection coil DC1, an exciting coil EC2 and a detection coil DC2, which are mounted on a disk DS. The eddy current testing probe is placed so as to face a circumferential surface of an object to be inspected T, which is in the shape of a circular cylinder, and the disk DS is rotated. Then, the distance (liftoff) between the detection coils DC1 and DC2 and an inspection surface changes. Therefore, also the detection sensitivity to a flaw signal changes. To reduce the change in detection sensitivity, the detection sensitivity is adjusted by detecting the rotational position (rotational angle) of the detection coils DC1 and DC2.
    Type: Application
    Filed: December 14, 2009
    Publication date: June 28, 2012
    Inventors: Takashi Hibino, Takashi Fujimoto, Keisuke Komatsu, Yoshiyuki Nakao, Makoto Takata, Makoto Sakamoto
  • Patent number: 8188277
    Abstract: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: May 29, 2012
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Tae Fukushima, Shuji Matsumura, Noriaki Takemura, Hideaki Satou, Nobuaki Ito, Takuya Shitsuta, Hironori Tsutsui, Michinori Tanaka, Keizo Kan, Hitoshi Nagao, Kenji Watanabe, Kuninori Tai, Takashi Nakagawa, Hideki Takasu, Makoto Sakamoto, Keisuke Miyajima, Satoshi Yamada, Yutaka Kojima, Koichi Yasumura, Naoto Ohi, Mitsuhiro Okuno, Kazuhisa Sugiyama, Kunihiko Kiyono, Takashi Suzuki, Seiji Akamatsu, Takeshi Kodama, Yasuo Yanagihara, Takumi Sumida
  • Publication number: 20120092005
    Abstract: A rotary eddy current flaw detection probe device has a plurality of ?-shaped eddy current flaw detection probes attached in a rotating disc for detecting flaws in all directions regardless of the flaw direction. Four ?-shaped eddy current testing probes P11 to P22 are arranged around the rotation center Ds1 of a rotating disc 111, and are embedded in the disc 111. The coil planes of detector coils Ds11 to Ds22 of the testing probes P11 to P22 are parallel with each other, and are perpendicular to the rotation plane of the rotating disc 111. The coil planes of the detector coils incline at an angle ? relative to a line Y passing through the centers Ps11 and Ps12 of the probes P11 and P12. The detector coils Dc11 and Dc12 are cumulatively connected to each other, and the detector coils Dc21 and Dc22 are differentially connected to each other.
    Type: Application
    Filed: November 1, 2011
    Publication date: April 19, 2012
    Applicant: SUMITOMO METAL INDUSTRIES, LTD.
    Inventors: Takashi HIBINO, Takashi Fujimoto, Shigeki Namekata, Keisuke Komatsu, Yoshiyuki Nakao, Makoto Takata, Makoto Sakamoto
  • Publication number: 20120067127
    Abstract: The present invention provides a method which allows simply, easily and accurately evaluating the fastening state of shoulder parts of a threaded joint for use as a joint of pipes or tubes, such as OCTG, during fastening or after fastening. The fastening state evaluation method for a threaded joint 100 of pipes or tubes according to the present invention is characterized in that it transmits ultrasonic surface waves from the internal surface of either one of the pin 1 and the box 2 toward the internal surface of the other one of the pin 1 and the box 2 through the shoulder parts 13, 23 of the pin 1 and the box 2, and on the basis of the transmitted wave intensity or the reflected wave intensity thereof, determines whether or not the fastening state of the threaded joint 100 is satisfactory.
    Type: Application
    Filed: September 22, 2011
    Publication date: March 22, 2012
    Applicant: SUMITOMO METAL INDUSTRIES, LTD.
    Inventors: Ikuji HOSHINO, Masaki YAMANO, Makoto SAKAMOTO, Keiichi NAKAMURA, Jun MASUBUCHI, Kenta SAKAI
  • Publication number: 20110071537
    Abstract: Disclosed is an intra-medullary rod, including: a cylindrical body made of an X-ray transmitting material; a plurality of wires, which are made of a material that does not transmit X-ray and are deposited at regular intervals along a surface of the cylindrical body in the circumferential direction, being extended in an axial direction in a spiral shape, wherein each of the wires is made in a way that a starting end and a terminating end of the cylindrical body are connected by the shortest distance along the outer surface thereof. In a fluoroscopic image of the cylindrical body, a distance from a reference position to an intersection location of a pair of the wires corresponds to an amount of rotational angle of the intra-medullary rod. By digitizing the intersection location, the rotational angle of the intra-medullary rod is measured.
    Type: Application
    Filed: March 31, 2004
    Publication date: March 24, 2011
    Inventors: Yoshio Koga, Makoto Sakamoto, Toshikazu Matsumoto, Yuji Tanabe
  • Publication number: 20100261720
    Abstract: The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.
    Type: Application
    Filed: October 29, 2008
    Publication date: October 14, 2010
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Takumi Sumida, Fujio Tabusa, Kazuo Sekiguchi, Takeshi Kodama, Koichi Yasumura, Yutaka Kojima, Masaaki Motoyama, Keisuke Miyajima, Kenji Yoshida, Keizo Kan, Makoto Sakamoto, Hideki Takasu, Takashi Nakagawa, Naoto Ohi, Yasuo Harada, Norikazu Hashimoto, Hironori Matsuyama, Masatoshi Iida, Shigekazu Fujita, Tae Fukushima
  • Publication number: 20100004438
    Abstract: An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group -Z-R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
    Type: Application
    Filed: December 4, 2006
    Publication date: January 7, 2010
    Inventors: Hironori Matsuyama, Kenji Ohnishi, Takashi Nakagawa, Hideki Takasu, Makoto Sakamoto, Kumi Higuchi, Keisuke Miyajima, Satoshi Yamada, Masaaki Motoyama, Yutaka Kojima, Koichi Yasumura, Takeshi Kodama, Shun Otsuji, Keizo Kan, Takumi Sumida
  • Publication number: 20080110533
    Abstract: A non-heat treated seamless steel pipe comprising, by weight, C: 0.10 to 0.25%, Si: 0.05 to 1.00%, Mn: 0.50 to 2.50%, P: not more than 0.03%, S: not more than 0.05%, Cr: 0.40 to 1.50%, Mo: 0.05 to 1.50%, V: 0.02 to 0.30%, Al: 0.003 to 0.10%, B: 0.0003 to 0.01%, and N: 0.001 to 0.02%, in which the balance comprises Fe and impurities. According to this non-heat treated seamless steel pipe, a ferrite area ratio is not more than 10%, and a carbon equivalent Ceq. (%) defined by the following equation is 0.45 to 0.85%. Ceq.
    Type: Application
    Filed: December 21, 2007
    Publication date: May 15, 2008
    Inventor: Makoto Sakamoto
  • Publication number: 20070270422
    Abstract: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group -Z-R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
    Type: Application
    Filed: August 3, 2005
    Publication date: November 22, 2007
    Inventors: Tae Fukushima, Shuji Matsumura, Noriaki Takemura, Hideaki Satou, Nobuaki Ito, Takuya Shitsuta, Hironori Tsutsui, Michinori Tanaka, Keizo Kan, Hitoshi Nagao, Kenji Watanabe, Kuninori Tai, Takashi Nakagawa, Hideki Takasu, Makoto Sakamoto, Keisuke Miyajima, Satoshi Yamada, Yutaka Kojima, Koichi Yasumura, Naoto Ohi, Mitsuhiro Okuno, Kazuhisa Sugiyama, Kunihiko Kiyono, Takashi Suzuki, Seiji Akamatsu, Takeshi Kodama, Yasuo Yanagihara, Takumi Sumida