Abstract: A medicine injection device includes a medicine ejection unit having a fluid flow-in port for receiving liquid, and a pressure generation unit which includes a pressure generating chamber to generate pressure acting upon a working chamber of the medicine ejection unit through the liquid and which ejects medicine by moving a gasket based on the applied pressure. The pressure generation unit includes a pressure portion cylinder in the pressure generating chamber, a first pusher provided with a hollow gasket defining the inner volume of the pressure generating chamber and a second pusher which generates the pressure inside the pressure generating chamber by pressing a distal end head portion into the inside of the pressure generating chamber. The pressure portion cylinder and the first pusher are coupled through an engagement mechanism in which fixation and fixation release are possible at different pitches in the axial direction.

Abstract: A bone cement injection needle comprises: a hollow outer needle; an outer needle hub affixed to the base end part of the outer needle; an inner needle that can be slidably inserted into the hollow part of the outer needle; and an inner needle hub affixed to the base end part of the inner needle. The outer needle comprises a first side hole located near the tip; a second side hole located near the base end part; and a depressurization passage which connects the first side hole and the second side hole.

Abstract: A manufacturing method of an artificial organ formed of a material having a solubility parameter &dgr; of not more than 13 (cal/cm3)½ involves filling micropores of the body fluid treatment membrane with a filling solution having no or little solubility with respect to a fat-soluble modifier solution, and coating a portion of the body fluid treatment membrane with the fat-soluble modifier by contacting the fat-soluble modifier solution. With this method substantially only the necessary portions need to be coated with the fat-soluble modifier so that a smaller amount of the fat-soluble modifier may be employed. A microporous membrane is formed of a synthetic polymer substrate having a solubility parameter &dgr; of not more than 13 (cal/cm3)½, with not less than 50 wt % of fat-soluble modifier included in the hollow fiber membrane being held on a surface which may contact body fluid. The membrane possesses the following sieve coefficients measured by dextrans: no more than 0.

Abstract: A process for producing a hollow fiber membrane, a hollow fiber membrane, and a dialyzer of hollow fiber membrane type is provided. The hollow fiber membrane is highly biocompatible, and the production process is quite simple and inexpensive. In the process of the invention, the hollow fiber membrane is produced in a system wherein a polymer-containing spinning solution is extruded from a tube-in-tube type orifice of a spinner in a coagulation solution to form the hollow fiber membrane. The polymer-containing spinning solution is extruded from the outer tube of the orifice to form a cylindrical filament having an inner bore and a core solution is ejected from the inner tube of the orifice into the inner bore of the filament for coagulation of the filament. The filament is directly extruded into the coagulation solution or extruded into air and then drawn to the coagulation solution.

Abstract: A medical material which comprises an oil-soluble vitamin hydrophobically bound to a hydrophobic moiety containing macromer which is bound to the surface of a polymeric substrate via a copolymer is described. Suitable macromers include for example glycidyl methacrylate-linoleic acid. Suitable polymeric substrate materials include, in particular, cellulose. Methods for producing said medical material are also provided.

Abstract: A method for the production of a hollow fiber membrane by the steps of discharging a spinning dope through an annular spinning nozzle and, at the same time, introducing a non-coagulating liquid for the spinning dope into the central cavity in a hollow fiber of the spinning dope being discharged, and then introducing the discharged fiber of the spinning dope into a coagulating liquid thereby solidifying the discharged fiber into a hollow fiber membrane, which method is characterized by incorporating a surface modifying agent in said non-coagulating liquid thereby modifying the inner surface behavior of the produced hollow fiber membrane.

Abstract: The cellulosic hollow-fiber membranes of the invention are useful in fluid processing apparatus typically for artificial dialysis. Each fiber has a tubular microporous wall having micropores and defining a lumen. The micropores have an average pore diameter of about 55 to about 300 .ANG.. The cellulosic hollow fibers exhibit a percent removal of .beta..sub.2 -microglobulin through adsorption of up to 10% after a solution of 20 mg/l of .beta..sub.2 -microglobulin in water is circulated through the fiber lumen for 3 hours. They also exhibit a sufficient filtration fraction of .beta..sub.2 -microglobulin and a ultrafiltration rate to remove .beta..sub.2 -microglobulin from blood predominantly through filtration while preventing contamination of the membranes with .beta..sub.2 -microglobulin due to adsorption and controlling the amount of water removed from the blood.