Abstract: A timepiece device with multiple-hand includes: one or more hands driven to rotate by one or more driving motors; one or more gear train mechanisms include gears which transmit a rotation movement of the driving motors to the hands; and a support plate which supports the gears; wherein the gears include: a first gear which includes a pair of gear members provided on front and rear sides of the support plate; a second gear which meshes with a gear member provided on the rear side to transmit a rotation movement of one of the driving motors to the first gear; and a third gear which meshes with a gear member provided on the front side to transmit a rotation movement of one of the driving motors to the hands.

Abstract: The present invention relates to polypeptides having a brain-localizing activity, molecules comprising these polypeptides, and pharmaceutical agents that confer brain-localizing activity. The present inventors are the first to reveal amino acid motif sequences involved in brain-localizing activity. Polypeptides that comprise such motif sequences and have brain localizing activity were discovered as follows: DNAs encoding polypeptides comprising random amino acid sequences were synthesized, and incorporated into a phage library. The phage library produced was used to screen for polypeptides having brain-localized activity, which yielded such several polypeptides. These polypeptides comprised common sequences, which lead to the successful discovery of amino acid motif sequences involved in brain-localizing activity.

Abstract: Provided is a protective film having high transparency, high ultraviolet absorption ability, high weatherability and flexibility, and not being peeled from its coating layers from a plastic film even if irradiated with ultraviolet. the protective film. The protective film comprises a plastic film and a coating layer on the surface of the plastic film, wherein the coating layer comprises a binder and core-shell type zinc oxide particles dispersed in the binder, the core-shell type zinc oxide particles have an average particle size of 50 nm or less and comprises a shell having a thickness of 1.5 nm to 20 nm.

Abstract: The object of the invention is to provide a protective film which comprises a plastic film and a coating layer and which has high transparency, high ultraviolet absorption ability, high weatherability and flexibility. The coating layer comprises a siloxane series binder and cerium oxide particles having an average particle size of 50 nm or less.

Abstract: To provide a sterilization method of container-packaged food which has a high effect on mixture food of solid food/soup and a filling system where all processes and devices can be simplified, a pre-seal lid material (PS), that has been cut to a dimension covering the opening of a cup filled with solid food, e.g. a dimension corresponding to the outer circumference of the flange of the cup, is fixed to a cup holder (CH) at a position for covering the cup opening by means of a holding bolt (31a) without being fusion bonded to the cup flange portion (CF), while a ventilation state between the head space of the cup and the air in a sterilization chamber is maintained. Thereafter, steam sterilization to the cup is performed in the sterilization chamber and the cup is transported to a clean box, filled with sterilized soup.

Abstract: A controlling system of a vehicle with a continuously variable transmission, which can render a sufficient accelerating feeling in responsive to a driver's requirement. A controller, upon judgment of an acceleration requirement, sets a target drive force higher than the target drive force upon normal calculation upon normal operation of an accelerator pedal, and sets a target rotation speed upon acceleration higher than the target rotation speed upon the normal operation and increasing with an increase of the vehicle speed by a predetermined gradient. The speed change ratio of the continuously variable transmission and the output torque of the engine are controlled such that the set target drive force is achieved, and an input shaft rotation speed of the continuously variable transmission coincides with the target rotation speed upon the set acceleration. Thus upon acceleration, the target drive force and the output rotation speed of the drive source increase.

Abstract: A method for producing contents filled in a container comprising steps of introducing a polyester container with a non-crystallized neck portion into a sterilized closed space having sterility and closed state on a commercial basis and comprising at least space in which a bottle sterilizing process is performed, space in which a filling process is performed and space in which a sealing process is performed, entire inner surface of said sterilized closed space and surface of an apparatus disposed in said sterilized closed space being sterilized by wet heating of the space using heated water and/or steam, at least the space in which the filling process is performed and the space in which the sealing process is performed being kept under a positive pressure by sterilized air; heating and sterilizing the container at least in its inner surface by wet heating using hot water and/or steam; and filling the contents in the sterilized container at a filling temperature within a temperature range from 40° C.

Abstract: Brain-localizing polypeptides carrying a reactive group for linking to a molecule that does not have brain-localizing activity were successfully produced by introducing at least two lysine residues into cyclized polypeptides having a brain-localizing motif sequence. These polypeptides have improved metabolic stability compared to conventional brain-localizing polypeptides, and can efficiently translocate desired molecules into the brain.

Abstract: [Problems] To obtain a spouted pouch package having a high degree of deoxidation by a method in which even a liquid content which is easily foamable can be filled while being inhibited from foaming. [Means for Solving Problems] A pre-filling deoxidation step (1) is performed before a liquid content is filled into a pouch. The pre-filling deoxidation step (1) comprises: a vacuum step (1-1) in which a gas is evacuated from the pouch; an inert gas blowing step (1-2) in which an inert gas is blown into the pouch after the vacuum step; and a gas-reduction vacuum step (1-3) in which the gas in the pouch after the inert gas blowing step is discharged under vacuum to reduce the gas in the pouch to a predetermined amount. Thereafter, the pouch is evacuated in a pre-filling second degassing step (2-1) and then filled with a content. After filling, gas replacement is implemented.

Abstract: A free standing film having excellent mechanical strength and flexibility as well as sufficient area is provided. The organic-inorganic hybrid free standing film includes an organic polymer having a constitutional repeating unit derived from a monomer represented by general formula (1) and a hydrolytic condensate of a metal alkoxide.

Abstract: It was discovered that cells expressing brain-localizing polypeptides on the cell surface can pass through the blood-brain barrier and therefore have the activity of translocating to the brain. By introducing desired substances into such brain-localizing cells, the substances can also be translocated to the brain. For example, by intravenously administering brain-localizing cells into which pharmaceutical agents having therapeutic effects on brain diseases have been introduced, such agents can be efficiently delivered into the brain and the brain diseases can be effectively treated.

Abstract: A controlling system for a vehicle with a continuously variable transmission, which can render a sufficient accelerating feeling in responsive to a driver's requirement. A controller, upon judgment of an acceleration requirement, sets a target drive force higher than the target drive force upon normal calculation upon normal operation of an accelerator pedal, and sets a target rotation speed for acceleration higher than the target rotation speed upon the normal operation and increasing with an increase of the vehicle speed by a predetermined gradient. The speed change ratio of the continuously variable transmission and the output torque of the engine are controlled such that the set target drive force is achieved, and an input shaft rotation speed of the continuously variable transmission coincides with the target rotation speed for the set acceleration.

Abstract: DNAs encoding polypeptides comprising random amino acid sequences were synthesized, and incorporated into a phage library. The phage library produced was used to screen for polypeptides having brain-localizing activity. As a result, several polypeptides having brain-localizing activity were obtained. These polypeptides comprise common sequences, and amino acid motif sequences involved in brain-localizing activity were successfully identified.

Abstract: The present inventors discovered that brain-localizing cells exist in the progenitor cell fraction of bone marrow cells. They also elucidated various characteristics of the brain-localizing cells. When these cells are infused into the bloodstream, they circulate in the blood and directly translocate into the cerebral parenchyma from the bloodstream. Furthermore, the present inventors succeeded in developing methods for efficiently preparing brain-localizing cells from bone marrow or bone marrow cells. These methods can be applied to less-invasive regenerative medicines targeting the brain and using autologous cells.

Abstract: In an electronic device having a metal device case, and an antenna disposed inside the device case, a magnetic member having a magnetic permeability higher than a magnetic permeability of the device case is placed between an inner surface of the device case and the antenna.

Abstract: The present inventors intravenously administered laboratory animals with molecules in which peptides and colloidal metal particles had been bound, to discover that the molecules translocated to the brain, specifically into cerebral neurons. Since activity to translocate into cerebral neurons could not be observed when the metal colloids were not bound, this activity was suggested to be a property of the colloidal metal particles. Desired compounds can be translocated into cerebral neurons by binding them to the colloidal metal particles. Furthermore, by using as carriers conjugate molecules in which peptides having brain-localizing activity are bound to the colloidal metal particles of the present invention, desired compounds can be delivered into cerebral neurons by intravenous administration.

Abstract: A method for sterilizing a container includes a step of spraying a bactericide which has been heated to a temperature within a range from 45° C. to 95° C. over at least an interior surface of the container standing with its mouth being positioned upside in a heated atmosphere. An apparatus for sterilizing a container includes: a temperature regulated sterilizing chamber having an inlet for receiving the container and an outlet for delivering out the container and containing heated air; temperature regulating means for regulating the temperature of the air in the sterilizing chamber to a predetermined temperature; container conveying means for conveying the container standing with its mouth being positioned upside from the inlet to the outlet of the sterilizing chamber; and one or more nozzles provided in the sterilizing chamber for spraying a bactericide which has been heated to a temperature within a range from 45° C. to 95° C.

Abstract: A method for manufacturing contents such as a drink contained in a container such as a PET bottle by filling the contents in the container, sealing the container and sterilizing the container includes steps of: filling the contents in a polyester container having a non-crystallized neck portion; sealing the container; and sterilizing the container in such a manner that temperature of the neck portion of the container during sterilization is maintained within a temperature range which is 61° C. or over and less than a glass transition temperature determined by moisture content of the container.

Abstract: There is provided a hydraulic control apparatus for a belt CVT, which is comprised of a pulley pressure control section that controls the line pressure in accordance with the oil amount balance of an oil pump based on the engine speed and the oil temperature during a select-judgment period from the detection of a change from a driving range to a non-driving range or a change from the non-driving range to the driving range to the lapse of a predetermined period of time, or when the non-driving range is detected. This eliminates the possibility that the oil pump cannot generate a specified oil pressure due to a decrease in the engine speed. Further, the secondary pressure is multiplied by the ratio of the line pressure in accordance with the oil amount balance of the oil pump to the line pressure which has been intended to be specified, and the secondary pressure is controlled according to the calculation result. This makes it possible to maintain the pulley ratio without causing a down-shift of the belt CVT.

Abstract: In case a primary hydraulic pressure sensor is normal, when reverse rotation of pulleys is detected a primary pulley (Plpri) torque capacity is calculated from a primary pressure detected by the primary hydraulic pressure sensor. When the primary hydraulic pressure sensor fails, a secondary hydraulic pressure sensor is checked, and when the secondary hydraulic pressure sensor is normal, the PLpri torque capacity is determined from a secondary pressure detected by the secondary hydraulic pressure sensor by using a map. On the other hand, when the secondary hydraulic pressure sensor fails too, the PLpri torque capacity is read out from the map by using a secondary pressure target value as the secondary pressure.