Patents by Inventor Makoto Takahagi

Makoto Takahagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230025076
    Abstract: A composition containing Brilliant Blue G (BBG) or a pharmaceutically acceptable salt thereof, and a positional isomer of Brilliant Blue G (BBG) or a pharmaceutically acceptable salt thereof, the composition containing 90 wt % or more and 100 wt % or less of one or both of Brilliant Blue G (BBG) and the pharmaceutically acceptable salt thereof in the total of the Brilliant Blue G (BBG), the pharmaceutically acceptable salt of Brilliant Blue G (BBG), the positional isomer of Brilliant Blue G (BBG), and the pharmaceutically acceptable salt of the positional isomer of Brilliant Blue G (BBG), a method for producing said composition, and a method of removing the ocular membrane of a human patient.
    Type: Application
    Filed: September 1, 2022
    Publication date: January 26, 2023
    Inventors: Makoto TAKAHAGI, Nobuhiro HAGA, Atsushi INOUE
  • Patent number: 11534505
    Abstract: A composition containing Brilliant Blue G (BBG) or a pharmaceutically acceptable salt thereof, and a positional isomer of Brilliant Blue G (BBG) or a pharmaceutically acceptable salt thereof, the composition containing 90 wt % or more and 100 wt % or less of one or both of Brilliant Blue G (BBG) and the pharmaceutically acceptable salt thereof in the total of the Brilliant Blue G (BBG), the pharmaceutically acceptable salt of Brilliant Blue G (BBG), the positional isomer of Brilliant Blue G (BBG), and the pharmaceutically acceptable salt of the positional isomer of Brilliant Blue G (BBG), a method for producing said composition, and a method of removing the ocular membrane of a human patient.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: December 27, 2022
    Assignee: D. WESTERN THERAPEUTICS INSTITUTE, INC.
    Inventors: Makoto Takahagi, Nobuhiro Haga, Atsushi Inoue
  • Publication number: 20180264142
    Abstract: A composition containing Brilliant Blue G (BBG) or a pharmaceutically acceptable salt thereof, and a positional isomer of Brilliant Blue G (BBG) or a pharmaceutically acceptable salt thereof, the composition containing 90 wt % or more and 100 wt % or less of one or both of Brilliant Blue G (BBG) and the pharmaceutically acceptable salt thereof in the total of the Brilliant Blue G (BBG), the pharmaceutically acceptable salt of Brilliant Blue G (BBG), the positional isomer of Brilliant Blue G (BBG), and the pharmaceutically acceptable salt of the positional isomer of Brilliant Blue G (BBG), a method for producing said composition, and a method of removing the ocular membrane of a human patient.
    Type: Application
    Filed: May 18, 2018
    Publication date: September 20, 2018
    Inventors: Makoto TAKAHAGI, Nobuhiro HAGA, Atsushi INOUE
  • Patent number: 7804592
    Abstract: The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: September 28, 2010
    Assignee: NARD Institute, Ltd.
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi
  • Publication number: 20090185181
    Abstract: The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound.
    Type: Application
    Filed: October 12, 2004
    Publication date: July 23, 2009
    Applicant: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi
  • Publication number: 20090087378
    Abstract: It is an objective of the present invention to provide a positron tomography method applicable to the diagnosis of specific brain diseases and to provide a positron-emitting compound for use in the method. The present invention method relates to a positron tomography method for measuring a distribution and concentration of a positron-emitting source, and is characterized in using the compound (I) as the positron-emitting source.
    Type: Application
    Filed: February 16, 2007
    Publication date: April 2, 2009
    Applicant: NARD INSTITUTE, LTD.
    Inventors: Masaaki Matsuo, Takeru Kitashoji, Tatsuhiro Kobashi, Makoto Takahagi, Hideo Tsukada, Shingo Nishiyama
  • Patent number: 7202093
    Abstract: Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods. The complex compound is represented by the formula: wherein X is a linker moiety, and Y is a labeling group. The compound (I) is highly coordinated to a phosphorylated peptide, and has a labeling group. Accordingly, with use of the compound (I), the phosphorylated peptide can be easily identified.
    Type: Grant
    Filed: February 23, 2004
    Date of Patent: April 10, 2007
    Assignee: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi
  • Publication number: 20040198712
    Abstract: Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods.
    Type: Application
    Filed: February 23, 2004
    Publication date: October 7, 2004
    Applicant: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi