Patents by Inventor Makoto Takeo

Makoto Takeo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN VITRO GROWTH METHOD FOR HAIR FOLLICULAR EPITHELIAL STEM CELLS
    Publication number: 20210380940
    Abstract: To provide means for efficient growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs. Provided are a culture medium for growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs, the culture medium comprising basal medium and at least (1) through (3), below: and a method for growing the epithelial cells using the culture medium: (1) at least one species of BMP inhibitor: (2) at least one species of fibroblast growth factor: and (3) at least one species of sonic hedgehog (SHH) and/or SHH agonist.
    Type: Application
    Filed: September 19, 2019
    Publication date: December 9, 2021
    Applicants: ORGAN TECHNOLOGIES, INC., RIKEN
    Inventors: Takashi Tsuji, Kyosuke Asakawa, Makoto Takeo, Koh-ei Toyoshima, Miho Ogawa, Yutaka Mori, Kyosuke Kishimoto
  • NAIL STEM CELLS AND METHODS OF USE THEREOF
    Publication number: 20140356333
    Abstract: The present invention is directed to an in vitro method for promoting proliferation, survival, and/or differentiation of K14+, K17+ nail stem cells (NSCs). The instant methods may be used to generate an expanded population of K14+, K17+ NSCs in vitro and expanded NSC populations in which a Wnt pathway is activated are envisioned as therapeutic agents. Methods for screening to identify agents capable of modulating K14+, K17+ NSC proliferation, survival, and/or differentiation are also encompassed herein, as are isolated, pure populations of homogeneous K14+, K17+ NSCs.
    Type: Application
    Filed: June 4, 2014
    Publication date: December 4, 2014
    Inventors: Mayumi Ito, Makoto Takeo