Abstract: A device for fixing a toner image on an image forming medium in an image forming apparatus includes a heating roller and a supporting roller for supporting the sheet of paper and transporting the paper, the heating roller having an inner peripheral surface, and at least one electrically resistive layer on the inner surface of the heating roller for fixing the toner image on the paper and reducing heat loss from the heating roller. Further, the device includes a pair of electrodes at opposite ends of the resistive layer for transmitting electrical power to the resistive layer.

Abstract: The present invention relates to biologically active substances obtained by reacting Islets-Activating Protein having an insulin secretion promoting action with a carbonyl compound in the presence of a reducing agent; to anti-diabetic composition in dosage unit form comprising the substance of the present invention; to pertussis vaccine in dosage unit form comprising the substance of the present invention; and to a process for the preparation of the same. The substances of the present invention are suppressed in leukocytosis-promoting effect.