Patents by Inventor Makoto Tsubokawa

Makoto Tsubokawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Screening method for neuroprotective compounds
    Patent number: 5264371
    Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
    Type: Grant
    Filed: March 23, 1992
    Date of Patent: November 23, 1993
    Assignee: Neurex Corporation
    Inventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro, Makoto Tsubokawa
  • Method of reducing neuronal damage using omega conotoxin peptides
    Patent number: 5189020
    Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
    Type: Grant
    Filed: August 2, 1990
    Date of Patent: February 23, 1993
    Assignee: Neurex Corporation
    Inventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro, Makoto Tsubokawa
  • Single-polarization optical fiber
    Patent number: 4913521
    Abstract: A single-polarization optical fiber comprising a core, an inner cladding surrounding the core, an outer cladding surrounding the inner cladding and at least one pair of stress-applying portions each of which are partially extended into both the inner and outer claddings and which are symmetrical about the axis of the core and having thermal expansion coefficient higher than those of both the inner and outer claddings. When the refractive index of the stress-applying portions is lower than that of the core and higher than that of the inner cladding and further not higher than that of the outer cladding, one of orthogonally polarized mode is cutoff and only one polarized mode can propagate in the optical fiber.
    Type: Grant
    Filed: December 2, 1988
    Date of Patent: April 3, 1990
    Assignee: Nippon Telegraph and Telephone Corporation
    Inventors: Katsusuke Tajima, Yutaka Sasaki, Masaharu Ohashi, Makoto Tsubokawa, Nobuo Kuwaki