Patents by Inventor Mala S. Mahendroo

Mala S. Mahendroo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adipose-specific promoter region of human aromatase cytochrome P450 gene
    Patent number: 5446143
    Abstract: The present invention relates generally to the control and regulation of estrogen biosynthesis. Estrogen biosynthesis is catalyzed by a microsomal enzyme, aromatase cytochrome P450 (P450arom; the product of the CYP19 gene). Tissue-specific expression of P450arom is determined by the use of tissue-specific promoters which give rise to P450arom transcripts with unique 5' noncoding sequences. Two unique 5'-untranslated exons of the CYP19 gene, I.3 and I.4., which are present in adipose tissue and adipose stromal cells (ASC) in culture have been identified. I.3-specific sequence is expressed in adipose tissue as well as in ACS maintained under all culture conditions, I.4-specific sequence is apparently present only in breast adipose tissue, and ACS stimulated with gluocorticoids.
    Type: Grant
    Filed: September 14, 1993
    Date of Patent: August 29, 1995
    Assignee: Board of Regents, the University of Texas System
    Inventors: Evan R. Simpson, Mala S. Mahendroo, Carole R. Mendelson