Patents by Inventor Malayannan Subramaniam

Malayannan Subramaniam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSGENIC TIEG NON-HUMAN ANIMALS
    Publication number: 20080300184
    Abstract: Materials and Methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. In addition, materials and methods related to the treatment of hypertrophic cardiomyopathy are provided.
    Type: Application
    Filed: October 5, 2007
    Publication date: December 4, 2008
    Inventors: Thomas C. Spelsberg, Malayannan Subramaniam, Merry Jo Velasquez, Nalini M. Rajamannan
  • Transgenic TIEG non-human animals
    Patent number: 7304203
    Abstract: Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. In addition, materials and methods related to the treatment of hypertrophic cardiomyopathy are provided.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: December 4, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Thomas C. Spelsberg, Malayannan Subramaniam, Merry Jo Velasquez, Nalini M. Rajamannan
  • Transgenic tieg non-human animals
    Publication number: 20060048238
    Abstract: Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. In addition, materials and methods related to the treatment of hypertrophic cardiomyopathy are provided.
    Type: Application
    Filed: September 17, 2004
    Publication date: March 2, 2006
    Inventors: Thomas Spelsberg, Malayannan Subramaniam, Merry Velasquez, Nalini Rajamannan
  • Determining cancer aggressiveness
    Publication number: 20030198961
    Abstract: The invention provides materials and methods for determining the aggressiveness of a cancer in a mammal. Specifically, the invention provides methods and methods for measuring the level of a TIEG marker in a sample. Such levels can be correlated with the aggressiveness of a cancer to predict patient outcome and develop treatment regimens.
    Type: Application
    Filed: April 15, 2002
    Publication date: October 23, 2003
    Inventors: Thomas C. Spelsberg, Patrick C. Roche, Monica Reinholz, Steven A. Johnsen, Malayannan Subramaniam
  • TGF-&bgr; inducible early factor-1 (TIEF-1) and a method to detect breast cancer
    Patent number: 6207375
    Abstract: Methods to determine TIEF-1 polypeptide, or genetic rearrangements in the TIEF-1 gene, in a sample are provided. Also provided are TIEF-1 specific antibodies and nucleic acid probes, and methods of employing those antibodies and probes to detect breast cancer in situ in a mammalian tissue sample.
    Type: Grant
    Filed: July 7, 1998
    Date of Patent: March 27, 2001
    Assignee: Mayo Foundation for Medical Educational & Research
    Inventors: Malayannan Subramaniam, Thomas C. Spelsberg, Patrick C. Roche
  • DNA encoding TGF-.beta. inducible early factor-1 (TIEF-1), a gene expressed by osteoblasts
    Patent number: 5981217
    Abstract: An isolated and purified DNA molecule encoding TGF-.beta. inducible early factor-1 (TIEF-1) is provided. A method of isolating a growth factor- or differentiation factor-inducible gene is also provided.
    Type: Grant
    Filed: December 11, 1995
    Date of Patent: November 9, 1999
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Malayannan Subramaniam, Thomas C. Spelsberg