Patents by Inventor Malcolm Adams

Malcolm Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the maturation of dendritic cells and a vaccine
    Patent number: 7981673
    Abstract: The invention proves a method of producing mature dendritic cells in vitro, which comprises the step of culturing the immature dendritic cells in the presence of a specifically configured high molecular weight double stranded RNA (dsRNA) polymer. The specifically configured high molecular weight dsRNA polymer is typically selected from the group comprising poly[I]:poly [CxU]; poly [I]:poly [GxU]; poly [A]: poly [UxC]; poly [A]:poly [UxG]; poly [U]:poly [AxC]; poly [U]:poly [IxU]; poly [C]:poly [GxA]; poly [C]:poly [GxU]; poly [G]:poly [CxA]; poly [G]:poly [CxU] and AMPLIGEN® (poly[I]:poly[C12U]), where x is on average a number from 3 to 40. The immature dendritic cells may be exposed to an antigen before they are matured, and a vaccine including the antigen-presenting mature dendritic cells can then be prepared. A method of treating cancer, a virus, parasite and microorganism is also disclosed.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: July 19, 2011
    Assignee: Biociones (Propietary) Limited
    Inventors: Malcolm Adams, Cyril Donninger
  • Process for the maturation of dentritic cells and a vaccine
    Publication number: 20040253722
    Abstract: The invention proves a method of producing mature dendritic cells in vitro, which comprises the step of culturing the immature dendritic cells in the presence of a specifically configured high molecular weight double stranded RNA (dsRNA) polymer. The specifically configured high molecular weight dsRNA polymer is typically selected from the group comprising poly[I]: poly [CxU]; poly [I]: poly [GxU]; poly [A]: poly [UxC]; poly [A]: poly [UxG]; poly [U]: poly [AxC]; poly [U]: poly [IxU]; poly [C]: poly [GxA]; poly [C]: poly [GxU]; poly [G]: poly [CxA]; poly [G]: poly [CxU] and Ampligen, where x is on average a number from 3 to 40. The immature dendritic cells may be exposed to an antigen before they are matured, and a vaccine including the antigen-presenting mature dendritic cells can then be prepared.
    Type: Application
    Filed: July 29, 2004
    Publication date: December 16, 2004
    Inventors: Malcolm Adams, Cyril Donninger