Abstract: The invention provides the compounds of formula (I) and pharmaceutically acceptable salts thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl; R3 is selected from the group consisting of C1-6alkyl, NH2 and R6CONH; R4 is H or C1-6alkyl; R5 is selected from the group consisting of CH2F, CHF2, CF3CH2, CF3CHF and CF3CF2; A is a 5- or 6-membered aryl, or a 5- or 6-membered aryl substituted by one or more R7; R6 is selected from the group consisting of H, C1-6alkyl, C1-6alkoxy, C1-6alkylOC1-6alkyl, phenyl, HO2CC1-6alkyl, C1-6alkylOCOC1-6alkyl, C1-6alkylOCO, H2NC1-6alkyl, C1-6alkylOCONHC1-6alkyl and C1-6alkylCONHC1-6alkyl; R7 is selected from the group consisting of halogen, C1-6alkyl, C1-6alkyl substituted by one or more F, C1-6alkoxy, C1-6alkoxy substitued by one or more F, SO2NH2 or SO2C1-6alkyl; and n is 1 to 4.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.

Abstract: A compound of formula (I) ##STR1## wherein, R.sup.1 is hydrogen, halogen or C.sub.1-6 alkyl;R.sup.2 is a group of formula --CR.sup.3 R.sup.4 (CH.sub.2).sub.p NR.sup.5 COR.sup.6 ;R.sup.3, R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or C.sub.l-6 alkyl;R.sup.6 is C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl;n is an integer of 2, 3 or 4;p is an integer of 1, 2, 3 or 4;and pharmaceutically acceptable salts and solvates thereof. A compound of formula (I) is useful in the treatment of conditions associated with a disturbed functioning of the melatonin system.