Patents by Inventor Malcolm Clive Carter
Malcolm Clive Carter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160339027Abstract: A pharmaceutical formulation comprising the compound of formulaType: ApplicationFiled: August 3, 2016Publication date: November 24, 2016Applicant: NOVARTIS AGInventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey, Stephen Barry Guntrip, Kathryn Jane Smith
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Publication number: 20160051551Abstract: A pharmaceutical formulation comprising the compound of formulaType: ApplicationFiled: October 20, 2015Publication date: February 25, 2016Applicant: NOVARTIS AGInventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey, Stephen Barry Guntrip, Kathryn Jane Smith
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Patent number: 9199973Abstract: A pharmaceutical formulation comprising the compound of formulaType: GrantFiled: November 10, 2014Date of Patent: December 1, 2015Assignee: Novartis AGInventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
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Publication number: 20150065527Abstract: A pharmaceutical formulation comprising the compound of formulaType: ApplicationFiled: November 10, 2014Publication date: March 5, 2015Inventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
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Patent number: 8912205Abstract: A pharmaceutical formulation comprising the compound of formulaType: GrantFiled: July 16, 2013Date of Patent: December 16, 2014Assignee: GlaxoSmithKline LLCInventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
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Publication number: 20130310562Abstract: A pharmaceutical formulation comprising the compound of formulaType: ApplicationFiled: July 16, 2013Publication date: November 21, 2013Applicant: GlaxoSmithKline LLCInventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
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Patent number: 8513262Abstract: A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) wherein L and L? are suitable leaving groups, with a compound of formula (III) UNH2??(III) to prepare a compound of formula (IV) and subsequently (b) substituting the group R1 by replacement of the leaving group L?.Type: GrantFiled: January 22, 2010Date of Patent: August 20, 2013Assignee: GlaxoSmithKline LLCInventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
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Patent number: 8008303Abstract: Use of a compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of Hepatitis C wherein the variables are described herein.Type: GrantFiled: September 18, 2006Date of Patent: August 30, 2011Assignee: AstraZeneca ABInventors: Christopher James Wheelhouse, Alexander James Floyd Thomas, David John Bushnell, James Lumley, James Iain Salter, Malcolm Clive Carter, Neil Mathews, Christopher John Pilkington, Richard Martyn Angell
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Publication number: 20100267755Abstract: The invention provides the compounds of formula (I) and pharmaceutically acceptable salts thereof, in which: R1 and R2 are independently selected from the group consisting of H, C1-6alkyl, C1-2alkyl substituted by one to five fluorine atoms, C3-6alkenyl, C3-6alkynyl, C3-10cycloalkylC0-6alkyl, C4-12bridged cycloalkyl, A(CR7R8)n and B(CR7R8)n; R3 is selected from the group consisting of C1-6alkyl, NH2 and R10CONH; R4 is C1-2alkyl substituted by one to five fluorine atoms; R5 is selected from the group consisting of H, C1-4alkyl, C1-2alkyl substituted with one to five fluorine atoms, halogen and C3-10cycloalkylC0-6alkyl, with the proviso that when R6 is H R5 is not H.Type: ApplicationFiled: May 23, 2002Publication date: October 21, 2010Applicants: GLAXO GROUP LIMITED, Jennifer Margaret GREENInventors: Gianpaolo Bravi, Malcolm Clive Carter, Richard Howard Green, Jennifer Margaret Doughty, Charles David Hartley, Alan Naylor, Martin Pass, Jeremy John Payne, Neil Anthony Pegg
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Publication number: 20100215618Abstract: The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6 and L are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of hepatitis C virus.Type: ApplicationFiled: February 23, 2010Publication date: August 26, 2010Applicant: Arrow Therapeutics LimitedInventors: Malcolm Clive Carter, Neil Mathews
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Publication number: 20080255105Abstract: A compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof wherein: R1 is a C1-C6 alkyl group or a moiety -A1, -L1-A1, -A1-A1?, -L1-A1-A1?, -A1-L1-A1?, -A1-Y1-A1?, -A1-Het1-A1?, -L1-A1-Y1-A1?, -L1-A1-Het1-A1?, -L1-Het1-A1, -L1-Y1-A1, -L1-Y1-Het1-A1, -L1-Het1-Y1-A1, -L1-Y1-Het1-L1?, -A1-Y1-Het1-A1?, -A1-Het1-Y1-A1?, -A1-Het1-L1-A1?, -A1-L1-Het1-A1? or -L1-Het1-L1?; -A and B are the same or different and each represent a direct bond or a —CO—NR?—, —NR?—CO—, —NR?—CO2—, —CO—, —NR?—CO—NR?—, —NR?—S(O)2—, —S(O)2—NR?—, —SO2—, —NR?—, —NR?—CO—CO—, —CO—O—, —O—CO—, —(C1-C2 alkylene)-NR?— or —(C1-C2 hydroxyalkylene)-NR?-moiety, wherein R? and R? are the same or different and each represent hydrogen or C1-C4 alkyl; —R2 and R3 are the same or different and each represent C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy or halogen; n and m are the same or different and each represent 0 or 1; R4 is a C1-C6 alkyl group or a moiety -A4, -L4-A4, -A4-A4?, -L4-A4-A4?, -A4-L4Type: ApplicationFiled: September 18, 2006Publication date: October 16, 2008Inventors: Christopher James Wheelhouse, Alexander James Floyd Thomas, David John Bushnell, James Lumley, James Iain Salter, Malcolm Clive Carter, Neil Mathews, Christopher John Pilkington, Richard Martyn Angell
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Patent number: 7109333Abstract: A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) ?wherein L and L? are suitable leaving groups, with a compound of formula (III) UNH2??(III) to prepare a compound of formula (IV) and subsequently (b) substituting the group R1 by replacement of the leaving group L?.Type: GrantFiled: February 3, 2005Date of Patent: September 19, 2006Assignee: SmithKline Beecham CorporationInventors: Malcolm Clive Carter, George Stuart Cockerill, Stephen Barry Guntrip, Karen Elizabeth Lackey, Kathryn Jane Smith
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Patent number: 7084148Abstract: A compound of formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1 is H or C1-6alkyl; R2 is wherein defines the point of attachment of the ring; and R3 is C1-6alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of pain, fever, inflammation of a variety of conditions and diseases.Type: GrantFiled: August 31, 2001Date of Patent: August 1, 2006Assignee: SmithKline Beecham CorporationInventors: Malcolm Clive Carter, Alan Naylor, Martin Pass, Jeremy John Payne, Neil Anthony Pegg
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Patent number: 6828320Abstract: Substituted heteroaromatic compounds, and in particular substituted quinolines and quinazolines, are protein tyrosine kinase inhibitors. The compounds are described as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of cancer and psoriasis.Type: GrantFiled: January 31, 2002Date of Patent: December 7, 2004Assignee: SmithKline Beecham CorporationInventors: George Stuart Cockerill, Malcolm Clive Carter, Stephen Barry Guntrip, Kathryn Jane Smith
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Patent number: 6780870Abstract: The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl; R3 is C1-6alkyl or NH2; R4 is H or C1-6alkyl; A is a 5- or 6-membered aryl, or a 5- or 6-membered aryl substituted by one or more R5; R5 is halogen, C1-6alkyl, C1-6alkyl substituted by one ore more F, C1-6alkoxy, C1-6alkoxy substituted by one or more F, SO2NH2 or SO2C1-6alkyl; and n is 1 to 4.Type: GrantFiled: July 31, 2002Date of Patent: August 24, 2004Assignee: SmithKline Beecham CorporationInventors: Malcolm Clive Carter, Alan Naylor, Jeremy John Payne, Neil Anthony Pegg
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Patent number: 6727256Abstract: Substituted heteroaromatic compounds of formula (I), wherein X is N or CH; Y is CR1 and V is N; or Y is N and V is CR1; or Y is CR1 and V is CR2; or Y is CR2 and V is CR1; R1 represents a group CH3SO2CH2CH2NHCH2—Ar—, wherein Ar is selected from phenyl, furan, thiophene, pyrrole and thiazole, each of which may optionally be substituted by one or two halo, C1-4alkyl or C1-4alkoxy groups; R2 is selected from the group comprising hydrogen, halo, hydroxy, C1-4alkyl, C1-4alkoxy, C1-4alkylamino and di[C1-4alkyl]amino; U represents a phenyl, pyridyl, 3H-imidazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, 1H-indazolyl, 2,3-dihydro-1H-indazolyl, 1H-benzimidazolyl, 2,3-dihydro-1H-benzimidazolyl or 1H-benzotriazolyl group, substituted by an R3 group and optionally substituted by at least one independently selected R4 group; R3 is selected from a group comprising benzyl, halo-, dihalo- and trihalobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, benzyloxy, halo-, dihalo- and trihalobenzyType: GrantFiled: June 30, 2000Date of Patent: April 27, 2004Assignee: SmithKline Beecham CorporationInventors: Malcolm Clive Carter, George Stuart Cockerill, Stephen Barry Guntrip, Karen Elizabeth Lackey, Kathryn Jane Smith
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Patent number: 6723726Abstract: Substituted heteroaromatic compounds, and in particular substituted bicyclic heteroaromatic compounds of formula (I), wherein X is N or CH; A represents a fused 5, 6 or 7-membered heterocyclic ring containing 1 to 5 heteroatoms which may be the same or different and which are selected from N, O or S(O)m, wherein m is as defined above, the heterocyclic ring containing a total of 1, 2 or 3 double bonds inclusive of the bond in the pyridine or pyrimidine ring to which it is fused, with the provisos that the heterocyclic ring does not form part of a purine and that the fused heterocyclic ring does not contain two adjacent O or S(O)m atoms.Type: GrantFiled: June 30, 2000Date of Patent: April 20, 2004Assignee: SmithKline Beecham CorporationInventors: George Stuart Cockerill, Malcolm Clive Carter, Stephen Barry Guntrip, Kathryn Jane Smith
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Patent number: 6713485Abstract: The present invention relates to substituted heteroaromatic compounds, methods for their preparation, pharmaceutical compositions containing them and their use in medicine. Specifically, the invention relates to quinazoline derivatives useful in treating disorders mediated by protein tyrosine kinase activity, in particular erbB-2 and/or EGFR activity.Type: GrantFiled: February 8, 2002Date of Patent: March 30, 2004Assignee: SmithKline Beecham CorporationInventors: Malcolm Clive Carter, George Stuart Cockerill, Stephen Barry Guntrip, Karen Elizabeth Lackey, Kathryn Jane Smith
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Publication number: 20030176451Abstract: A process for the preparation of a compound of formula (I) 1Type: ApplicationFiled: January 15, 2003Publication date: September 18, 2003Inventors: Malcolm Clive Carter, George Stuart Cockerill, Stephen Barry Guntrip, Karen Elizabeth Lackey, Kathryn Jane Smith
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Publication number: 20030109538Abstract: The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl, R3 is C1-6alkyl or NH2: R4 is H or C1-6alkyl: A is and 5- or 6-membered aryl, or a 5- or 6-membered aryl substituted by one or more R5; R5 is halogen, C1-6alkyl, C1-6alkyl substituted by one ore more F, C1-6alkoxy, C1-6alkoxy substituted by one or more F, SO2NH2 or SO2C1-6alkyl; and n is 1 to 4. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.Type: ApplicationFiled: July 31, 2002Publication date: June 12, 2003Inventors: Malcolm Clive Carter, Alan Naylor, Jeremy John Payne, Neil Anthony Pegg