Abstract: The invention is a novel class of materials made by combining the best qualities of both lead iron tantalate (PFT) and lead iron titanate (PZT) to synthesize (PbZr0.53Ti0.47O3)(1-x)—(PbFe0.5Ta0.5O3)x (PZTFT) (0.1?x?0.9) compositions that have multiferroic (ferroelectric and ferromagnetic) and magnetoelectric properties.

Abstract: A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand docking methods into an integrated process. In one embodiment, NMR data is used to filter docking results to identify the most consistent binding modes, thereby providing structural information in a high-throughput fashion without the need for assigning protein resonances. Trial assignments for protein-ligand nuclear Overhauser effect (NOE) interactions are also produced by the method.

Abstract: A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand docking methods into an integrated process. In one embodiment, NMR data is used to filter docking results to identify the most consistent binding modes, thereby providing structural information in a high-throughput fashion without the need for assigning protein resonances. Trial assignments for protein-ligand nuclear Overhauser effect (NOE) interactions are also produced by the method.

Abstract: A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand docking methods into an integrated process. In one embodiment, NMR data is used to filter docking results to identify the most consistent binding modes, thereby providing structural information in a high-throughput fashion without the need for assigning protein resonances. Trial assignments for protein-ligand nuclear Overhauser effect (NOE) interactions are also produced by the method.

Abstract: A flexible component-based software system is developed by generating a UML model (3) in a specification phase (4). Components are generated in an implementation phase (4). The UML model (3) is transformed to a meta model. A runtime architecture service (RAS, 10) dynamically assembles a system in runtime according to the meta model. A modelling tool (15) modifies the meta model via an API (34) and a meta modeller (31). This allows dynamic re-configuration of the system.

Abstract: A flexible component-based software system is developed by generating a UML model (3) in a specification phase (4). Components are generated in an implementation phase (4). The UML model (3) is transformed to a meta model. A runtime architecture service (RAS, 10) dynamically assembles a system in runtime according to the meta model. A modelling tool (15) modifies the meta model via an API (34) and a meta modeller (31). This allows dynamic re-configuration of the system.

Abstract: An air vent for a heating or air conditioning system comprising an air flow nozzle having a part spherical outer wall mounted within a housing which is substantially circular in cross section about a longitudinal axis and shaped to allow swivelling of the nozzle within it, the nozzle being mounted to the housing via a gimbal member, the gimbal member comprising two legs with a web extending between them, each leg extending between the housing and the nozzle wall in a longitudinal direction, each leg being pivotally attached to the housing at diametrically opposite points such that the gimbal member may rotate about a first axis with respect to the housing, the gimbal member also comprising a tongue extending from the web to the first axis between the pivot points of the housing and being pivotally attached to the nozzle about a second axis orthogonal to the first axis.