Abstract: A needle actuator assembly for a drug delivery system includes a housing, a needle having retracted and extended positions, a needle actuator body received within the housing and configured to move from a pre-use position where the needle is in the retracted position to a use position where the needle is in the extended position and to a post-use position where the needle is in the retracted position, with the needle actuator having a button contact surface, and an actuator button received by the housing.

Abstract: Methods, systems, and computer storage media for providing a concentrate grade recommendation using a concentrate grade optimization engine in a material processing engine of a material processing system. The concentrate grade recommendation refers to a quantified value for concentrate grade that corresponds to an economic value for ore of a mining process. In operation, input data comprising material processing planning data and economic data associated with a recovery process are accessed. The input data is analyzed using a grade recovery relationship machine learning model. The grade recovery relationship machine learning model is trained on historical material processing data features associated with concentrate grade and recovery of the material recovery process. The historical data includes data on produced concentrate (e.g., achieved grades and corresponding recovery). Based on analyzing the input data, a concentrate grade that corresponds to an economic value is generated.

Abstract: A thermal energy storing system includes two or more volumes of a formulation of active material. The formulation of active material in each of the two or more volumes includes a solvent and one or more of a salt, a base, or an acid as the active material. The formulation of active material in each of the two or more volumes also has multiple congruent solid/liquid phase transitions at different concentrations of the solvent. A phase transition temperature of each volume of the two or more volumes of the formulation of active material can be adjusted by changing the concentration of solvent in each formulation. This tunability notably improves the performance and cost effectiveness of heat pumps, shifting electrical loads to lower-cost, off-peak/renewable-intensive periods, improving efficiency, and enabling recovery of low-grade renewable and waste heat. The system has a relatively small footprint, which is particularly attractive in urban applications.

Abstract: A drug delivery system for injecting a medicament includes a housing, a container configured to receive a medicament including a stopper configured to move within the container and a closure, a needle in fluid communication with the container, a spacer configured to be engaged with the stopper, a first plunger, a first spring configured to bias the first plunger in an axial direction, second plunger disposed about the first plunger, a second spring configured to bias the second plunger in an axial direction. The first plunger is configured to move the spacer and the container relative to the housing via the first spring to establish fluid communication between the container and the patient needle, and the second plunger is configured to move the spacer and the stopper relative to the container via the second spring.

Abstract: The present invention relates to methods of producing a food or malt-based beverage suitable for consumption by a subject with Coeliac's disease. In particular, the present invention relates to methods of producing a food or malt-based beverage with very low levels of hordeins. Also provided are barley plants which produce grain that can be used in the methods of the invention.

Abstract: A fuel cell system includes a hotbox configured to house a fuel cell stack, the fuel cell stack including a temperature sensor configured to detect temperature inside the fuel cell stack. The system includes a first tank including a first valve and configured to store methanol. The system includes a second tank including a second valve and configured to store water. The system includes a controller communicatively coupled to receive signals from the temperature sensor and control each of the first valve and the second valve. The controller is configured to set a dosing rate of methanol, based on a temperature of the fuel cells stack, to a predefined dosing rate and initiate operating at least one of the first valve and the second valve to deliver a mixture of methanol and water at the predefined dosing rate to prevent re-oxidation of an anode of the fuel cell stack.

Abstract: The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: (I)

Abstract: The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I:

Abstract: Capturing and processing a digital image of a pictorial (e.g., hand-drawn) representation of a schematic or block diagram as a digital image to aid in creation and maintenance of electrical designs is disclosed. Processing of the digital image includes processing to determine design parameters to create an informational format useful as input to other design software. Design parameters may include schematic layout and attributes such as maximum output voltage, minimum input voltage, ambient temperature, etc. The method and system also include storage of information accessible to refine designs and perform simulations of designs as part of an overall electrical design process. Associated devices and methods are disclosed as well.

Abstract: The present invention relates to methods of producing a food or malt-based beverage suitable for consumption by a subject with Coeliac's disease. In particular, the present invention relates to methods of producing a food or malt-based beverage with very low levels of hordeins. Also provided are barley plants which produce grain that can be used in the methods of the invention.

Abstract: The invention relates to benzodiazepine derivatives of formula (A) useful as CCK2/gastrin receptor antagonists, their preparation and their use in the treatment or prevention of disorders associated with CCK2/gastrin receptors, disorders caused by or associated with hypergastrinaemia, and gastric acid-related disorders.

Abstract: Capturing and processing a digital image of a pictorial (e.g., hand-drawn) representation of a schematic or block diagram as a digital image to aid in creation and maintenance of electrical designs is disclosed. Processing of the digital image includes processing to determine design parameters to create an informational format useful as input to other design software. Design parameters may include schematic layout and attributes such as maximum output voltage, minimum input voltage, ambient temperature, etc. The method and system also include storage of information accessible to refine designs and perform simulations of designs as part of an overall electrical design process. Associated devices and methods are disclosed as well.

Abstract: The present invention relates to methods of producing a food or malt-based beverage suitable for consumption by a subject with Coeliac's disease. In particular, the present invention relates to methods of producing a food or malt-based beverage with very low levels of hordeins. Also provided are barley plants which produce grain that can be used in the methods of the invention.

Abstract: Capturing and processing a digital image of a pictorial (e.g., hand-drawn) representation of a schematic or block diagram as a digital image to aid in creation and maintenance of electrical designs is disclosed. Processing of the digital image includes processing to determine design parameters to create an informational format useful as input to other design software. Design parameters may include schematic layout and attributes such as maximum output voltage, minimum input voltage, ambient temperature, etc. The method and system also include storage of information accessible to refine designs and perform simulations of designs as part of an overall electrical design process. Associated devices and methods are disclosed as well.

Abstract: The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I:

Abstract: The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: (I)

Abstract: A sealing apparatus for mitigating emissions of a hazardous gas flowing between first and second regions. A body of the apparatus includes at least one inlet, at least one outlet spaced apart from the at least one inlet, and a channel connecting the at least one inlet and the at least one outlet in fluid communication. Treatment material housed in at least a portion of the channel is adapted to treat the hazardous gas to form a conditioned gas. In use, the hazardous gas being emitted from the first region is received at the at least one inlet, and the conditioned gas is discharged to the second region at the at least one outlet. The apparatus may be used in combination with a storage container housing radioactive or other toxic waste.

Abstract: The invention relates to benzodiazepine derivatives of formula (A) useful as CCK2/gastrin receptor antagonists, their preparation and their use in the treatment or prevention of disorders associated with CCK2/gastrin receptors, disorders caused by or associated with hypergastrinaemia, and gastric acid-related disorders.

Abstract: Capturing and processing a digital image of a pictorial (e.g., hand-drawn) representation of a schematic or block diagram as a digital image to aid in creation and maintenance of electrical designs is disclosed. Processing of the digital image includes processing to determine design parameters to create an informational format useful as input to other design software. Design parameters may include schematic layout and attributes such as maximum output voltage, minimum input voltage, ambient temperature, etc. The method and system also include storage of information accessible to refine designs and perform simulations of designs as part of an overall electrical design process. Associated devices and methods are disclosed as well.