Abstract: Two clocks, a fast clock and a slow clock are provided for clocking a processing unit. A plurality of frequency settings, referred to as gears, are defined for the two clock. Each of these gears indicates a maximum frequency for the fast clock and a minimum frequency for the slow clock, such that the gap between the two frequencies may be kept to a manageable level so as to reduce transients upon switching between the two clocks. The system switches between the gears as required. In response to a determination to increase the frequency of the clock signal, a higher gear is selected at which the maximum and minimum frequencies defined for that gear are higher than the previous selected gear.

Abstract: A system and method for docking a processing unit provided. According to the method, the system dithers between the two signals provided by the two clock generators so as to clock the processing unit at an average clock frequency having a value between the frequencies of the two signals. The average clock frequency is adjusted by modifying the proportion of time spent on one clock signal vs the other clock signal.

Abstract: The application relates to a series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives and 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted by an arylaminophenyl or heteroarylaminophenyl moiety. The compounds are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful as pharmaceutical agents for the treatment of malaria.

Abstract: A system and method for docking a processing unit provided. According to the method, the system dithers between the two signals provided by the two clock generators so as to clock the processing unit at an average clock frequency having a value between the frequencies of the two signals. The average clock frequency is adjusted by modifying the proportion of time spent on one clock signal vs the other clock signal.

Abstract: Two clocks, a fast clock and a slow clock are provided for clocking a processing unit. A plurality of frequency settings, referred to as gears, are defined for the two clock. Each of these gears indicates a maximum frequency for the fast clock and a minimum frequency for the slow clock, such that the gap between the two frequencies may be kept to a manageable level so as to reduce transients upon switching between the two clocks. The system switches between the gears as required. In response to a determination to increase the frequency of the clock signal, a higher gear is selected at which the maximum and minimum frequencies defined for that gear are higher than the previous selected gear.

Abstract: The application relates to a series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives and 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted by an arylaminophenyl or heteroarylaminophenyl moiety. The compounds are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful as pharmaceutical agents for the treatment of malaria.

Abstract: The invention relates to compositions and methods for enhancing mucus functions such as but not limited to improved respiratory tract mucus clearance. The compositions of the invention are mucothickening compositions. They can be used to improve mucus clearance in a subject in need thereof, such as in the treatment of conditions related to non-functioning cilia or to excessively thin mucus.

Abstract: The present invention is for a charged dextran, preferably dextran sulfate, as an improved mucoactive agent which can be used to improve viscoelasticity and clearance of respiratory tract mucus. The charged dextran can be used in the treatment of animals with impaired mucus clearance, mucus retention and/or mucus hypersecretion, such as cystic fibrosis, chronic bronchitis, bronchiectasis, bronchiolitis and bronchial asthma. Related methods of treatment and pharmaceutical compositions, particularly aerosolized dextran sulfate compositions are encompassed within the scope of the invention.

Abstract: This invention relates to the use of polysaccharide such as dextran to improve mucus clearance. In the present invention, dextran has been shown to reduce viscoelasticity and increase mucus clearability of sputum of cystic fibrosis patients. Dextran also reduced viscoelasticity of healthy dog mucus. The present invention therefore may be used to improve mucus clearance in cystic fibrosis patients and treat other conditions associated with defect in airway mucus clearance including chronic bronchitis, bronchiectasis and bronchial asthma.

Abstract: This invention relates to the use of polysaccharide such as dextran to improve mucus clearance. In the present invention, dextran has been shown to reduce viscoelasticity and increase mucus clearability of sputum of cystic fibrosis patients. Dextran also reduced viscoelasticity of healthy dog mucus. The present invention therefore may be used to improve mucus clearance in cystic fibrosis patients and treat other conditions associated with defect in airway mucus clearance including chronic bronchitis, bronchiectasis and bronchial asthma.

Abstract: A data processing system dynamically balances allocation of storage areas in a shared coupling facility that is devoted to storage of directory entries and data blocks. Each directory entry includes information regarding the validity of a data block that is locally stored by one or more processor modules in the data processing system. The system includes a coupling facility having a cache memory wherein a first portion is allocated to storage of data blocks and a second portion is allocated to storage of directory entries. Each directory entry, associated with a data block, indicates the validity or invalidity of data contained in a copy of the data block maintained by a connected computer module in its local memory. Each computer module, upon requiring a first data block and determining that (i) the first data block is present in its local memory (i.e., a buffer "hit"), but (ii) is not marked valid and (iii) is not present in the coupling facility (i.e.