Patents by Inventor Malcolm King

Malcolm King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions And Methods For Improved Mucus Function
    Publication number: 20070275091
    Abstract: The invention relates to compositions and methods for enhancing mucus functions such as but not limited to improved respiratory tract mucus clearance. The compositions of the invention are mucothickening compositions. They can be used to improve mucus clearance in a subject in need thereof, such as in the treatment of conditions related to non-functioning cilia or to excessively thin mucus.
    Type: Application
    Filed: March 30, 2005
    Publication date: November 29, 2007
    Inventors: Malcolm King, Gustavo Zayas
  • Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
    Publication number: 20040224922
    Abstract: The present invention is for a charged dextran, preferably dextran sulfate, as an improved mucoactive agent which can be used to improve viscoelasticity and clearance of respiratory tract mucus. The charged dextran can be used in the treatment of animals with impaired mucus clearance, mucus retention and/or mucus hypersecretion, such as cystic fibrosis, chronic bronchitis, bronchiectasis, bronchiolitis and bronchial asthma. Related methods of treatment and pharmaceutical compositions, particularly aerosolized dextran sulfate compositions are encompassed within the scope of the invention.
    Type: Application
    Filed: February 23, 2004
    Publication date: November 11, 2004
    Inventor: Malcolm King
  • Use of dextran and other polysaccharides to improve mucus clearance
    Publication number: 20020032172
    Abstract: This invention relates to the use of polysaccharide such as dextran to improve mucus clearance. In the present invention, dextran has been shown to reduce viscoelasticity and increase mucus clearability of sputum of cystic fibrosis patients. Dextran also reduced viscoelasticity of healthy dog mucus. The present invention therefore may be used to improve mucus clearance in cystic fibrosis patients and treat other conditions associated with defect in airway mucus clearance including chronic bronchitis, bronchiectasis and bronchial asthma.
    Type: Application
    Filed: June 28, 2001
    Publication date: March 14, 2002
    Inventors: Malcolm King, David P. Speert
  • Use of dextran and other polysaccharides to improve mucus clearance
    Patent number: 6339075
    Abstract: This invention relates to the use of polysaccharide such as dextran to improve mucus clearance. In the present invention, dextran has been shown to reduce viscoelasticity and increase mucus clearability of sputum of cystic fibrosis patients. Dextran also reduced viscoelasticity of healthy dog mucus. The present invention therefore may be used to improve mucus clearance in cystic fibrosis patients and treat other conditions associated with defect in airway mucus clearance including chronic bronchitis, bronchiectasis and bronchial asthma.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: January 15, 2002
    Assignees: The University of British Columbia, The University of Alberta
    Inventors: Malcolm King, David P Speert