Patents by Inventor Malcolm Moos
Malcolm Moos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11270098Abstract: Methods are disclosed for clustering biological samples and other objects using a grand canonical ensemble. A biological sample is characterized by data attributes from varying sources (e.g. NGS, other types of high-dimensional cytometric data, observed disease state) and of varying data types (e.g. Boolean, continuous, or coded sets) organized as vectors (as many as 109) having as many as 106, 109, or more components. The biological samples or observational data are modeled as particles of a grand canonical ensemble which can be variably distributed among partitions. A pseudo-energy is defined as a measure of inverse similarity between the particles. Minimization of grand canonical ensemble pseudo-energy corresponds to clustering maximally similar particles in each partition, thereby determining clusters of the biological samples. The sample clusters can be used for feature discovery, gene and pathway identification, and development of cell based therapeutics, or for other purposes.Type: GrantFiled: November 15, 2018Date of Patent: March 8, 2022Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICESInventors: Elaine Ellen Thompson, Vahan Simonyan, Malcolm Moos, Jr.
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Publication number: 20200311384Abstract: Methods are disclosed for clustering biological samples and other objects using a grand canonical ensemble. A biological sample is characterized by data attributes from varying sources (e.g. NGS, other types of high-dimensional cytometric data, observed disease state) and of varying data types (e.g. Boolean, continuous, or coded sets) organized as vectors (as many as 109) having as many as 106, 109, or more components. The biological samples or observational data are modeled as particles of a grand canonical ensemble which can be variably distributed among partitions. A pseudo-energy is defined as a measure of inverse similarity between the particles. Minimization of grand canonical ensemble pseudo-energy corresponds to clustering maximally similar particles in each partition, thereby determining clusters of the biological samples. The sample clusters can be used for feature discovery, gene and pathway identification, and development of cell based therapeutics, or for other purposes.Type: ApplicationFiled: November 15, 2018Publication date: October 1, 2020Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICInventors: Elaine Ellen Thompson, Vahan Simonyan, Malcolm Moos, JR.
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Patent number: 7563596Abstract: An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle and nerve tissue formation. Frzb binds to and modulates the activity of Wnt growth factors which play a role in various developmental and neoplastic processes. The cDNA and protein sequences of human, bovine and Xenopus Frzb are provided. Production and purification of recombinant Frzb are also described.Type: GrantFiled: July 18, 2005Date of Patent: July 21, 2009Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Frank P. Luyten, Malcolm Moos, Jr., Bang Hoang, Shouwen Wang
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Publication number: 20080199443Abstract: Human cartilage-derived morphogenetic protein variant polypeptides and isolated nucleic acids are provided. Also provided are vectors, host cells, and recombinant methods for producing human cartilage-derived morphogenetic protein variants polypeptides. Therapeutic methods useful for treating musculoskeletal disorders and joint repair with such variants are also provided.Type: ApplicationFiled: June 8, 2006Publication date: August 21, 2008Applicant: The Govt. of the U.S.A. as represented by the Secretary, Dept. of Health and Human ServicesInventors: Malcolm Moos, J. Terrig Thomas
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Patent number: 7220558Abstract: Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can be used to repair cartilage defects in a mammal.Type: GrantFiled: March 3, 2003Date of Patent: May 22, 2007Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Frank P. Luyten, Malcolm Moos, Jr., Steven Chao-Huan Chang
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Publication number: 20070053991Abstract: Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can be used to repair cartilage defects in a mammal.Type: ApplicationFiled: November 3, 2006Publication date: March 8, 2007Inventors: Frank Luyten, Malcolm Moos, Steven Chang
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Patent number: 7148036Abstract: The present invention is a purified cartilage extract that stimulates local cartilage formation when combined with a matrix and implanted into a mammal. This extract can conveniently be produced by a method which includes the steps of: obtaining cartilage tissue; homogenizing the cartilage tissue in the presence of chaotropic agents under conditions that permit separation of proteins from proteoglycans; separating the proteins from the proteoglycans and then obtaining the proteins. The step for separating the proteins from the proteoglycans can be carried out using a sepharose column. The extract can also be obtained by additionally including the steps of separating the proteins on a molecular sieve and then collecting the proteins having molecular weights in the 30 kDa to 60 kDa size range. Articular cartilage or epiphyseal cartilage can be used in the preparation of this purified extract.Type: GrantFiled: May 19, 2000Date of Patent: December 12, 2006Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Frank P. Luyten, Malcolm Moos, Jr., Steven Chao-Huan Chang
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Publication number: 20060149050Abstract: An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle and nerve tissue formation. Frzb binds to and modulates the activity of Wnt growth factors which play a role in various developmental and neoplastic processes. The cDNA and protein sequences of human, bovine and Xenopus Frzb are provided. Production and purification of recombinant Frzb are also described.Type: ApplicationFiled: March 6, 2006Publication date: July 6, 2006Inventors: Frank Luyten, Malcolm Moos, Bang Hoang, Shouwen Wang
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Patent number: 7049291Abstract: An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle and nerve tissue formation. Frzb binds to and modulates the activity of Wnt growth factors which play a role in various developmental and neoplastic processes. The cDNA and protein sequences of human, bovine and Xenopus Frzb are provided. Production and purification of recombinant Frzb are also described.Type: GrantFiled: February 28, 2002Date of Patent: May 23, 2006Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Frank P. Luyten, Malcolm Moos, Jr., Bang Hoang, Shouwen Wang
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Publication number: 20050256052Abstract: An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle and nerve tissue formation. Frzb binds to and modulates the activity of Wnt growth factors which play a role in various developmental and neoplastic processes. The cDNA and protein sequences of human, bovine and Xenopus Frzb are provided. Production and purification of recombinant Frzb are also described.Type: ApplicationFiled: July 18, 2005Publication date: November 17, 2005Inventors: Frank Luyten, Malcolm Moos, Bang Hoang, Shouwen Wang
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Patent number: 6924367Abstract: An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle, and nerve tissue formation. Frzb binds to and modulates the activity of Wnt growth factors which play a role in various developmental and neoplastic processes. The cDNA and protein sequences of human, bovine and Xenopus Frzb are provided. Production and purification of recombinant Frzb are also described.Type: GrantFiled: December 19, 2001Date of Patent: August 2, 2005Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Frank P. Luyten, Malcolm Moos, Jr., Bang Hoang, Shouwen Wang
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Patent number: 6884871Abstract: An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle and nerve tissue formation. The CDNA and protein sequences of human and bovine frzb are provided. Production and purification of recombinant Frzb are also described.Type: GrantFiled: December 7, 2001Date of Patent: April 26, 2005Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Frank P. Luyten, Malcolm Moos, Jr., Bang Hoang, Shouwen Wang
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Publication number: 20030185898Abstract: the present invention is a purified cartilage extract that stimulates local cartilage formation when combined with a matrix and implanted into a mammal. This extract can conveniently be produced by a method which includes the steps of: obtaining cartilage tissue; homogenizing the cartilage tissue in the presence of chaotropic agents under conditions that permit separation of proteins from proteoglycans; separating the proteins from the proteoglycans and then obtaining the proteins. The step for separating the proteins from the proteoglycans can be carried out using a sepharose column. The extract can also be obtained by additionally including the steps of separating the proteins on a molecular sieve and then collecting the proteins having molecular weights in the 30 kDa to 60 kDa size range. Articular cartilage or epiphyseal cartilage can be used in the preparation of this purified extract.Type: ApplicationFiled: May 19, 2000Publication date: October 2, 2003Inventors: Frank P. Luyten, Malcolm Moos, Steven Chao-Huan Chang
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Publication number: 20030176683Abstract: Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can be used to repair cartilage defects in a mammal.Type: ApplicationFiled: March 3, 2003Publication date: September 18, 2003Inventors: Frank P. Luyten, Malcolm Moos, Steven Chao-Huan Chang
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Publication number: 20030139591Abstract: An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle and nerve tissue formation. The CDNA and protein sequences of human and bovine frzb are provided. Production and purification of recombinant Frzb are also described.Type: ApplicationFiled: December 7, 2001Publication date: July 24, 2003Inventors: Frank P. Luyten, Malcolm Moos, Bang Hoang, Shouwen Wang
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Publication number: 20030009023Abstract: An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle and nerve tissue formation. Frzb binds to and modulates the activity of Wnt growth factors which play a role in various developmental and neoplastic processes. The cDNA and protein sequences of human, bovine and Xenopus Frzb are provided. Production and purification of recombinant Frzb are also described.Type: ApplicationFiled: February 28, 2002Publication date: January 9, 2003Inventors: Frank P. Luyten, Malcolm Moos, Bang Hoang, Shouwen Wang
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Publication number: 20020147329Abstract: An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle, and nerve tissue formation. Frzb binds to and modulates the activity of Wnt growth factors which play a role in various developmental and neoplastic processes. The cDNA and protein sequences of human, bovine and Xenopus Frzb are provided. Production and purification of recombinant Frzb are also described.Type: ApplicationFiled: December 19, 2001Publication date: October 10, 2002Inventors: Frank P. Luyten, Malcolm Moos, Bang Hoang, Shouwen Wang
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Publication number: 20010037017Abstract: Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can be used to repair cartilage defects in a mammal.Type: ApplicationFiled: December 13, 2000Publication date: November 1, 2001Inventors: Frank P. Luyten, Malcolm Moos, Steven Chao-Huan Chang
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Publication number: 20010011131Abstract: Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can be used to repair cartilage defects in a mammal.Type: ApplicationFiled: December 5, 2000Publication date: August 2, 2001Inventors: Frank P. Luyten, Malcolm Moos, Steven Chao-Huan Chang
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Patent number: 5693779Abstract: An isolated polynucleotide of anti-dorsalizing morphogenetic protein (ADMP-1) is obtained from Xenopus. The protein is most closely related to human BMP-3. ADMP-1 functions as a modulator for dorsalizing influences, and prevents syndromes involving inappropriate proliferation of tissues.Type: GrantFiled: November 8, 1994Date of Patent: December 2, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Malcolm Moos, Jr., Marie Krinks, Shouwen Wang