Patents by Inventor Malcolm P. Toft

Malcolm P. Toft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoquinolinones
    Patent number: 5004747
    Abstract: Therapeutically useful isoquinolinone derivatives of the formula A--X--R.sup.3, wherein A represents a group of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R.sup.4 represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R.sup.6 O-- wherein R.sup.6 represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:--Y.sup.1 --CH.sub.2 --CH(OH)--CH.sub.2 --COOR.sup.5wherein Y.sup.1 represents carbonyl, hydroxymethylene or --C(OR).sub.2 -- wherein R represents alkyl or the two R symbols together represent alkylene and R.sup.5 represents hydrogen or optionally substituted alkyl or R.sup.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: April 2, 1991
    Assignee: May & Baker Limited
    Inventors: Michael J. Ashton, Andrew W. Bridge, Robert K. Chambers, Donald I. Dron, Garry Fenton, Neil V. Harris, David J. Lythgoe, Ian M. McFarlane, Christopher G. Newton, David Riddell, Christopher Smith, Keith A. J. Stuttle, Malcolm P. Toft