Patents by Inventor Malcolm R. Bell

Malcolm R. Bell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CB.sub.2 Receptor agonist compounds
    Patent number: 6013648
    Abstract: The use of human CB.sub.2 receptor-specific agonists of formula (I) or (I') for preparing immunomodulating drugs is disclosed. In formulae (I) and (I'), R.sub.1 is a group selected from --CH.sub.2 CHR.sub.10 NR.sub.6 R.sub.11, --(CH.sub.2).sub.2 NR'.sub.6 R'.sub.11, --CHR.sub.9 CH.sub.2 NR'.sub.6 R'.sub.11, --(CH.sub.2).sub.n Z and --COR.sub.8 ; R'.sub.1 is a --CH.sub.2 CHR.sub.10 NR.sub.6 R.sub.11 or --(CH.sub.2).sub.2 NR'.sub.6 R'.sub.11 group; R.sub.2 and R'.sub.2 are hydrogen, halogen or C.sub.1-4 alkyl; R.sub.3 is hydrogen, C.sub.1-4 alkyl or a group selected from --CH.sub.2 CHR.sub.10 NR.sub.6 R.sub.11, --(CH.sub.2).sub.2 NR'.sub.6 R'.sub.11 and --COR.sub.8 ; R'.sub.3 is a .dbd.CR.sub.6 R.sub.8 group; R.sub.4 has one of the meanings given for R.sub.5 or is a --COR.sub.8 group; R.sub.5 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, a halogen atom, a CF.sub.3 group, an OCF.sub.3 group or C.sub.1-4 alkylthio; R'.sub.5 has one of the meanings given for R.sub.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: January 11, 2000
    Assignee: Sanofi
    Inventors: Murielle Rinaldi, Francis Barth, Pierre Casellas, Christian Congy, Didier Oustric, Malcolm R. Bell, Thomas E. D'Ambra, Richard E. Philion
  • 3-arylcarbonyl-1(C-attached-N-heteryl)-1H-indoles
    Patent number: 5607933
    Abstract: 2--R.sub.2 --R.sub.4 -substituted-3--R.sub.3 --CO--1--[(C-attached-N-heteryl)-(Alk).sub.n ]--1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.
    Type: Grant
    Filed: March 16, 1994
    Date of Patent: March 4, 1997
    Assignee: Sterling Winthrop Inc.
    Inventors: Thomas E. D'Ambra, Edward R. Bacon, Malcolm R. Bell, Susan J. Ward
  • 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
    Patent number: 5597841
    Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an acid-acceptor.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: January 28, 1997
    Assignee: Sterling Winthrop, Inc.
    Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Virendra Kumar, Chakrapani Subramanyam, Ranjit C. Desai, Dennis J. Hlasta, Manohar T. Saindane, Malcolm R. Bell, John J. Court, Robert P. Farrell
  • 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
    Patent number: 5563163
    Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: October 8, 1996
    Assignee: Sterling Winthrop, Inc.
    Inventors: Richard P. Dunlap, Dennis J. Hlasta, Ranjit C. Desai, Lee H. Latimer, Chakrapani Subramanyam, John J. Court, Malcolm R. Bell, Virendra Kumar
  • 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
    Patent number: 5512589
    Abstract: A compound having the formula: ##STR1## wherein Ar, R.sup.4 and R.sup.5 are defined herein have pharmaceutical utility as proteolytic enzyme inhibitors.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: April 30, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Virendra Kumar, Chakrapani Subramanyam, Ranjit C. Desai, Dennis J. Hlasta, Manohar T. Saindane, Malcolm R. Bell, John J. Court, Robert P. Farrell
  • 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
    Patent number: 5488062
    Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.
    Type: Grant
    Filed: August 9, 1994
    Date of Patent: January 30, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Richard P. Dunlap, Dennis J. Hlasta, Ranjit C. Desai, Lee H. Latimer, Chakrapani Subramanyam, John J. Court, Malcolm R. Bell, Virendra Kumar
  • 3-arylcarbonyl-1-(C-attached-N-heteryl)-1H-indoles
    Patent number: 5324737
    Abstract: 2-R.sub.2 -R.sub.4 -substitutea-3-R.sub.3 -CO-1-[(C-attached-N-heteryl)(Alk).sub.n ]-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: June 28, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Thomas E. D'Ambra, Edward R. Bacon, Malcolm R. Bell, Philip M. Carabateas, Michael A. Eissenstat, Virendra Kumar, John P. Mallamo, Susan J. Ward
  • Tetrahydro 2-saccharinylmerthyl aryl carboxylates
    Patent number: 5306818
    Abstract: 4-R.sup.4 -R.sup.5 -Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an acid-acceptor.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: April 26, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Chakrapani Subramanyam, Malcolm R. Bell
  • 2-saccharinylmethyl aryl carboxylate
    Patent number: 5250696
    Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an acid-acceptor.
    Type: Grant
    Filed: March 30, 1992
    Date of Patent: October 5, 1993
    Assignee: Sterling Winthrop Inc.
    Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Virendra Kumar, Chakrapani Subramanyam, Ranjit C. Desai, Dennis J. Hlasta, Manohar T. Saindane, Malcolm R. Bell, John J. Court
  • Proteolytic enzyme inhibition method
    Patent number: 5128339
    Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an acid-acceptor.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: July 7, 1992
    Assignee: Sterling Winthrop Inc.
    Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Virendra Kumar, Chakrapani Subramanyam, Ranjit C. Desai, Dennis J. Hlasta, Manohar T. Saindane, Malcolm R. Bell, John J. Court
  • 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates
    Patent number: 5109135
    Abstract: 2- and 3-Aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines , useful as analgesic agents, are prepared either by reaction of a 2- or 3-aminomethyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine with an arylcarboxylic acid halide in the presence of a Lewis acid or by reaction of a 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine with a 1-lower-alkyl-3-aryl-1,3-diketone or with a .beta.-aryl-.beta.-ketopropionaldehyde under dehydrating conditions and heating the resulting hydrazone in an acid medium.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: April 28, 1992
    Assignee: Sterling Drug Inc.
    Inventors: Thomas E. D'Ambra, Malcolm R. Bell
  • Antiandrogenic sulfonylsteroidofurans
    Patent number: 5100882
    Abstract: 5'-Alkylsulfonylsteroido[3,2-b]furans, for example 5'-methylsulfonyl-5.alpha.-pregn-2-en-20-yno[3,2-b]furan-17.beta.-ol having the structural formula, ##STR1## which are useful as antiandrogenic agents, and processes for preparation, method of use and compositions thereof are disclosed.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: March 31, 1992
    Assignee: Sterling Drug Inc.
    Inventors: Robert G. Christiansen, Malcolm R. Bell, Virendra Kumar
  • 3-arylcarbonyl-1-(C-attached-N-heteryl)-1H-indoles
    Patent number: 5068234
    Abstract: 2-R.sub.2 -R.sub.4 -substituted-3-R.sub.3 -CO-1-[(C-attached-N-herteryl)-(Alk).sub.n ]-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: November 26, 1991
    Assignee: Sterling Drug Inc.
    Inventors: Thomas E. D'Ambra, Edward R. Bacon, Malcolm R. Bell, Philip M. Carabateas, Michael A. Eissenstat, Virendra Kumar, John P. Mallamo, Susan J. Ward
  • 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazin es
    Patent number: 5066803
    Abstract: 2- and 3-Aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines , useful as analgesic agents, are prepared either by reaction of a 2- or 3-aminomethyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine with an arylcarboxylic acid halide in the presence of a Lewis acid or by reaction of 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine with a 1-lower-alkyl-3-aryl-1,3-diketone or with a .beta.-aryl-.beta.-ketopropionaldehyde under dehydrating conditions and heating the resulting hydrazone in an acid medium.
    Type: Grant
    Filed: April 16, 1990
    Date of Patent: November 19, 1991
    Assignee: Sterling Drug Inc.
    Inventors: Thomas E. D'Ambra, Malcolm R. Bell
  • 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles
    Patent number: 5013732
    Abstract: 3-Arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, useful as analgesic, anti-rheumatic and anti-inflammatory agents, are prepared by reacting a 3-arylcarbonyl- or 3-cycloalkylcarbonylindole with an aminoalkyl halide in the presence of an acid-acceptor; by reacting a 1-aminoalkyl-1H-indole with an arylcarboxylic acid halide or a cycloalkanecarboxylic acid halide in the presence of a Lewis acid; or by reacting a 3-arylcarbonyl- or 3-cycloalkanecarbonyl-1-tosyloxyalkyl- or haloalkyl-1H-indole with an amine.
    Type: Grant
    Filed: July 30, 1990
    Date of Patent: May 7, 1991
    Assignee: Sterling Drug Inc.
    Inventor: Malcolm R. Bell
  • 3-Arylcarbonyl-1H-indole-containing compounds
    Patent number: 5013837
    Abstract: Antiglaucoma compositions containing 3-aryl-carbonyl-1-aminoalkyl-1H-indoles, as the active component thereof, and a method of use thereof in the treatment of glaucoma.
    Type: Grant
    Filed: August 3, 1990
    Date of Patent: May 7, 1991
    Assignee: Sterling Drug Inc.
    Inventors: Susan J. Ward, Malcolm R. Bell
  • 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indole pharmaceutical compositions
    Patent number: 4978664
    Abstract: 3-Arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, useful as analgesic, anti-rheumatic and anti-inflammatory agents, are prepared by reacting a 3-arylcarbonyl- or 3-cycloalkylcarbonylindoe with an aminoalkyl halide in the presence of an acid-acceptor; by reacting a 1-aminoalkyl-1H-indole with an arylcarboxylic acid halide or a cycloalkanecarboxylic acid halide in the presence of a Lewis acid; or by reacting a 3-arylcarbonyl- or 3-cycloalkanecarbonyl-1-tosyloxyalkyl- or haloalkyl-1H-indole with an amine.
    Type: Grant
    Filed: September 20, 1989
    Date of Patent: December 18, 1990
    Assignee: Sterling Drug Inc.
    Inventor: Malcolm R. Bell
  • 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method
    Patent number: 4973587
    Abstract: Antiglaucoma compositions containing 3-aryl-carbonyl-1-aminoalkyl-1H-indoles, as the active component thereof, and a method of use thereof in the treatment of glaucoma.
    Type: Grant
    Filed: March 8, 1990
    Date of Patent: November 27, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Susan J. Ward, Malcolm R. Bell
  • 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazin es
    Patent number: 4939138
    Abstract: 2- and 3-Aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines , useful as analgesic agents, are prepared either by reaction of a 2- or 3-aminomethyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine with an arylcarboxylic acid halide in the presence of a Lewis acid or by reaction of a 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine with a 1-lower-alkyl-3-aryl-1,3-diketone or with a .beta.-aryl-.beta.-ketopropionaldehyde under dehydrating conditions and heating the resulting hydrazone in an acid medium.
    Type: Grant
    Filed: December 7, 1989
    Date of Patent: July 3, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Thomas E. D'Ambra, Malcolm R. Bell
  • Pyrazolo[3,4-b]quinolines and their use as antiviral agents
    Patent number: 4920128
    Abstract: Pyrazolo[3,4-b]quinolines having the formula ##STR1## where R is hydrogen, hydroxy or alkoxy; R.sub.2 is halogen, cyano, carbamyl, carboxy, lower-alkylcarbonyl, amino or aminomethyl; and R.sub.1 is hydrogen or selected substituents as defined herein, are useful as antiviral agents and/or as vasodilators.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: April 24, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Malcolm R. Bell, James H. Ackerman