Patents by Inventor Malcolm Sheardown

Malcolm Sheardown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VDCC Gamma-8 Ion Channel
    Publication number: 20090180959
    Abstract: VDCC ?-8 polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3, SEQ ID NO. 5 or SEQ ID NO: 7, and homologues, variants and derivatives thereof are provided. Nucleic acids capable of encoding VDCC ?-8 polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID NO. 4 or SEQ ID NO: 6. These polypeptides and polynucleotides are implicated in mental illness and are useful in screening for therapeutic agents useful in treating mental illness.
    Type: Application
    Filed: September 4, 2006
    Publication date: July 16, 2009
    Inventors: John Dixon, Justin Powell, Malcolm Sheardown, Nicola Brice, Jennifer Marie Horwood, Isabelle Malinge, Haiping Liu, Kok Siu Foo
  • GPR 26 G-Protein Coupled Receptor
    Publication number: 20090048200
    Abstract: We disclose GPR26 G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding GPR26 polypeptide are also disclosed. The GPR26 receptor is useful in the diagnosis and therapy of mental illness.
    Type: Application
    Filed: October 30, 2006
    Publication date: February 19, 2009
    Inventors: Alan Hendrick, John Dixon, Tere Michelle Tait, Rosa Fradley, Malcolm Sheardown, Haiping Liu, Kok Siu Foo
  • Treatment of ischemias by administration of 2,N.sup.6 -substituted adenosines
    Patent number: 5683989
    Abstract: The present invention relates to compounds of formula I ##STR1## wherein X is amino, C.sub.1-6 -alkylamino, di-C.sub.1-6 -alkylamino;R.sup.1 is H, straight or branched C.sub.1-6 -alkyl or trifluoromethyl; R.sup.4 is H or straight or branched C.sub.1-6 -alkyl; or R.sup.1 and R.sup.4 together form a cyclobutyl, cyclopentyl or cyclohexyl ring;Y is O, S, SO.sub.2, N--H or N-alkyl;R.sup.5 is selected from optionally substituted heterocycles;R.sup.6 is hydrogen, benzoyl or C.sub.1-6 -alkanoyl andR.sup.7 is hydrogen, benzoyl or C.sub.1-6 -alkanoyl; ora pharmaceutically acceptable salt thereof.The compounds have been found useful for treating central nervous system and cardiovascular ailments.
    Type: Grant
    Filed: July 20, 1995
    Date of Patent: November 4, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Jesper Lau, Lars Jacob Stray Knutsen, Malcolm Sheardown, Anker Jon Hansen
  • 2, N.sup.6 -disubstituted adenosines, tri-O-ester derivatives and their pharmaceutical compositions to treat ischemias
    Patent number: 5484774
    Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein X is halogen, trifluoromethyl, cyano, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio, C.sub.1-6 -alkylamino or C.sub.1-6 -dialkylamino;R.sup.1 and R.sup.4 are H or straight or branched C.sub.1-6 -alkyl or trifluoromethyl or R.sup.1 and R.sup.4 together form a cycloalkyl ring;Y is O, S, SO.sub.2, NH or N-alkyl;R.sup.5 is selected from optionally substituted heterocycles.R.sup.6 and R.sup.7 are hydrogen, benzoyl or C.sub.1-6 -alkanoyl.The compounds have been found useful for treating central nervous system and cardiovascular ailments.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: January 16, 1996
    Assignee: Novo Nordisk A/S
    Inventors: Jesper Lau, Lars J. S. Knutsen, Malcolm Sheardown, Anker J. Hansen