Patents by Inventor Malene Bech Vester-Christensen

Malene Bech Vester-Christensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-Glycosylation
    Publication number: 20210102223
    Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
    Type: Application
    Filed: November 5, 2020
    Publication date: April 8, 2021
    Inventors: Henrik Clausen, Zhang Yang, Adnan Fevzi Halim, Eric Bennett, Carsten Behrens, Malene Bech Vester-Christensen, Shamim Herbert Rahman
  • N-Glycosylation
    Publication number: 20210095317
    Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
    Type: Application
    Filed: November 5, 2020
    Publication date: April 1, 2021
    Inventors: Henrik Clausen, Zhang Yang, Adnan Fevzi Halim, Eric Bennett, Carsten Behrens, Malene Bech Vester-Christensen, Shamim Herbert Rahman
  • N-Glycosylation
    Publication number: 20210087587
    Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
    Type: Application
    Filed: November 5, 2020
    Publication date: March 25, 2021
    Inventors: Henrik Clausen, Zhang Yang, Adnan Fevzi Halim, Eric Bennett, Carsten Behrens, Malene Bech Vester-Christensen, Shamim Herbert Rahman
  • Production of N-glycoproteins for enzyme assisted glycomodification
    Patent number: 10889845
    Abstract: The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: January 12, 2021
    Assignees: UNIVERSITY OF COPENHAGEN, DANMARKS TEKNISKE UNIVERSITET
    Inventors: Shamim Herbert Rahman, Carsten Behrens, Malene Bech Vester-Christensen, Henrik Clausen, Zhang Yang, Adnan Fevzi Halim, Eric Bennett
  • N-glycosylation
    Patent number: 10858671
    Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: December 8, 2020
    Assignees: University of Copenhagen, Dansmarks Tekniske Universitet
    Inventors: Henrik Clausen, Zhang Yang, Adnan Fevzi Halim, Eric Bennett, Carsten Behrens, Malene Bech Vester-Christensen, Shamim Herbert Rahman
  • PRODUCTION OF N-GLYCOPROTEINS FOR ENZYME ASSISTED GLYCOMODIFICATION
    Publication number: 20190203247
    Abstract: The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.
    Type: Application
    Filed: June 15, 2016
    Publication date: July 4, 2019
    Inventors: Shamim Herbert RAHMAN, Carsten BEHRENS, Malene Bech VESTER-CHRISTENSEN, Henrik CLAUSEN, Yang ZHANG, Adnan Fevzi HALIM, Eric BENNETT
  • N-GLYCOSYLATION
    Publication number: 20170369905
    Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
    Type: Application
    Filed: December 11, 2015
    Publication date: December 28, 2017
    Inventors: Henrik Clausen, Zhang Yang, Adnan Fevzi Halim, Eric Bennett, Carsten Behrens, Malene Bech Vester-Christensen, Shamim Herbert Rahman