Abstract: Oral care compositions and/or unit-dose oral care compositions with a non-inferior amount of fluoride. Unit-dose oral care compositions comprising greater than 850 ppm, greater than 1000 ppm, greater than 1150 ppm, greater than 1450 ppm, or greater than 2000 ppm of fluoride. Unit-dose oral care compositions with a salivary fluoride pK AUC that is at least 60% of the salivary fluoride pK AUC of 1.25 g of the appropriate reference toothpaste when dosed according to the manufacturer's instructions.

Abstract: Oral care compositions and/or unit-dose oral care compositions with a fluoride ion source. Oral care compositions and/or unit-dose oral care compositions with a high average fluoride ion uptake. Oral care compositions with one or more web forming materials, a calcium ion source, and a fluoride ion source with a high average fluoride uptake.

Abstract: Methods for detecting and quantifying toxins present in the oral cavity. The methods may include providing a biological sample, providing reporter cells expressing one or more Toll like receptors, exposing the cells to the biological sample, measuring the EC50 value of the lipopolysaccharide on activation of a Toll like receptor, quantification of the lipopolysaccharide in the biological sample.

Abstract: Methods for detecting and quantifying toxins present in the oral cavity. The methods may include providing a biological sample, providing reporter cells expressing one or more Toll like receptors, exposing the cells to the biological sample, measuring the EC50 value of the lipopolysaccharide on activation of a Toll like receptor, quantification of the lipopolysaccharide in the biological sample.

Abstract: Methods for detecting and quantifying toxins present in the oral cavity. The methods may include providing a biological sample, providing reporter cells expressing one or more Toll like receptors, exposing the cells to the biological sample, measuring the EC50 value of the lipopolysaccharide on activation of a Toll like receptor, quantification of the lipopolysaccharide in the biological sample.

Abstract: One or more methods for sampling gingival metabolites and biomarkers.

Abstract: One or more methods for sampling gingival metabolites and biomarkers.

Abstract: According to the embodiments described herein, a method for characterizing in vivo operation of a dental prosthetic can include providing subject position data and prosthetic position data. The method may further include transforming the subject position data into a reference three-dimensional coordinate system. The reference three-dimensional coordinate system can be ordered according to a coordinate index. The coordinate index can be based at least in part upon a subject position index of the subject position data. The method may further include comparing, automatically with one or more processors, the prosthetic position data and the reference three-dimensional coordinate system according to a comparison order to characterize the dental prosthetic. The comparison order can be based at least in part upon a prosthetic position index of the prosthetic position data and the coordinate index.

Abstract: Methods for detecting and quantifying toxins present in the oral cavity. The methods may include providing a biological sample, providing reporter cells expressing one or more Toll like receptors, exposing the cells to the biological sample, measuring the EC50 value of the lipopolysaccharide on activation of a Toll like receptor, quantification of the lipopolysaccharide in the biological sample.

Abstract: A therapeutic micro-current delivery device includes a first electrode in electrical contact with a user at a first user location, a second electrode in electrical contact with the user at a second user location, a power source operable to provide a first voltage potential at the first electrode and a second voltage potential at the second electrode, and a micro-current control circuit in electrical communication with the first electrode, second electrode and power source. Electrical contact of the first electrode at the first user location and electrical contact of the second electrode at the second user location completes an electrical circuit. The micro-current control circuit generates a micro-current Iramped through a user between the first location and the second location that increases from a start current Istart to an end current Iend over a rise time trise. Oral care devices and micro-current control methods are also disclosed.

Abstract: According to the embodiments described herein, a method for characterizing in vivo operation of a dental prosthetic can include providing subject position data and prosthetic position data. The method may further include transforming the subject position data into a reference three-dimensional coordinate system. The reference three-dimensional coordinate system can be ordered according to a coordinate index. The coordinate index can be based at least in part upon a subject position index of the subject position data. The method may further include comparing, automatically with one or more processors, the prosthetic position data and the reference three-dimensional coordinate system according to a comparison order to characterize the dental prosthetic. The comparison order can be based at least in part upon a prosthetic position index of the prosthetic position data and the coordinate index.

Abstract: A therapeutic micro-current delivery device includes a first electrode in electrical contact with a user at a first user location, a second electrode in electrical contact with the user at a second user location, a power source operable to provide a first voltage potential at the first electrode and a second voltage potential at the second electrode, and a micro-current control circuit in electrical communication with the first electrode, second electrode and power source. Electrical contact of the first electrode at the first user location and electrical contact of the second electrode at the second user location completes an electrical circuit. The micro-current control circuit generates a micro-current Iramped through a user between the first location and the second location that increases from a start current Istart to an end current Iend over a rise time trise. Oral care devices and micro-current control methods are also disclosed.

Abstract: An oral care composition for the treatment of dry mouth comprising a polyethylene oxide with a molecular weight from about 200,000 to about 7,000,000, an anti-bacterial agent, and a sensate.

Abstract: Disclosed are oral hygiene regimens comprising a plurality of steps involving the use of two or more oral care products containing actives effective to provide one or more benefits including cleaning, antimicrobial, antiplaque, anticaries, anti-calculus, anti-demineralizing, anti-erosion, antisensitivity/desensitizing, whitening, surface conditioning, polishing, and pH-balancing, wherein the plurality of steps are conducted and sequenced for maximizing delivery of oral care actives to target surfaces of a subject's oral cavity thereby achieving optimum oral health and hygiene benefits. In one aspect, a regimen comprises at least once daily of each of the following steps: (a) applying an antimicrobial dentifrice to oral cavity surfaces, and (b) rinsing the oral cavity with an antimicrobial mouthrinse, wherein at least one of steps (a) and (b) is conducted prior to retiring at night.