Patents by Inventor Malgorzata Krych

Malgorzata Krych has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified truncated complement system regulators
    Publication number: 20080119400
    Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which affect the complement inhibitory activities of these proteins, substituting, rearranging or adding SCRs (short consensus repeats) or SCR regions to the proteins, deleting amino acid sequences, and combinations thereof.
    Type: Application
    Filed: November 23, 2004
    Publication date: May 22, 2008
    Applicant: Washington University
    Inventors: John P. Atkinson, Dennis Hourcade, Malgorzata Krych
  • Modified RCA proteins
    Patent number: 6897290
    Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which affect the complement inhibitory activities of these proteins, substituting, rearranging or adding SCRs (short consensus repeats) or SCR regions to the proteins, deleting amino acid sequences, and combinations thereof.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: May 24, 2005
    Assignee: Washington University
    Inventors: John P. Atkinson, Dennis Hourcade, Malgorzata Krych
  • Cells expressing a modified regulator of complement activation
    Patent number: 6521450
    Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: February 18, 2003
    Assignee: Washington University
    Inventors: John P. Atkinson, Dennis Hourcade, Malgorzata Krych
  • Modified complement system regulators
    Patent number: 6010873
    Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (amino acids at positions 54-61 of SEQ ID NO. 13) (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 4, 2000
    Assignee: Washington University
    Inventors: John P. Atkinson, Dennis Hourcade, Malgorzata Krych
  • Modified complement system regulators
    Patent number: 5719127
    Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: February 17, 1998
    Assignee: Washington University
    Inventors: John P. Atkinson, Dennis Hourcade, Malgorzata Krych
  • Modified complement system regulators
    Patent number: 5545619
    Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (SEQ ID NO:1) (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: August 13, 1996
    Assignee: Washington University
    Inventors: John P. Atkinson, Dennis Hourcade, Malgorzata Krych