Patents by Inventor Malgorzata Mieszala

Malgorzata Mieszala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of lipopolysaccharide-protein conjugate vaccines via the lipid a region following removal of the glycosidic phosphate residue
    Publication number: 20050147624
    Abstract: This invention relates to lipopolysaccharide-protein conjugate vaccines with appropriate presentation of conserved inner core oligosaccharide epitopes having improved immunogenic properties. These are based upon antigenic, detoxified bacterial lipopolysaccharides which optimally present an inner core oligosaccharide epitope following removal of at least a glycosidic phosphate of the lipid A region. These partially or completely dephosphorylated antigenic, detoxified bacterial lipopolysaccharides are linkable to an immunologically acceptable carrier and can be used in polyvalent or multivalent vaccines.
    Type: Application
    Filed: February 24, 2003
    Publication date: July 7, 2005
    Inventors: Harold Jennings, Malgorzata Mieszala, Grigorij Kogan, Wei Zou, James Richards, Andrew Cox