Patents by Inventor Malgorzata Mysliwiec

Malgorzata Mysliwiec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic vaccine for treatment of diabetes type 1 in children, application of the cell sorter and the method of multiplying Treg cells to produce therapeutic vaccine for treatment of diabetes type 1
    Patent number: 11944672
    Abstract: The gist of the invention consists in the therapeutic vaccine for treatment of diabetes type 1 in children, which contains Treg cells CD3(+)CD4(+)CD25(high)CD127(?). Claimed too is the cell sorter used to produce the vaccine and the method of multiplying Treg cells in vitro.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: April 2, 2024
    Assignee: Gdanski Uniwersytet Medyczny
    Inventors: Piotr Trzonkowski, Malgorzata Mysliwiec, Natalia Marek-Trzonkowska
  • METHOD FOR EX VIVO EXPANSION OF REGULATORY T CELLS
    Publication number: 20210348126
    Abstract: The invention relates to a new method for in vitro expansion of CD4+CD25HighCD127?/LowFoxP3+ Tregs, wherein the process of Treg expansion takes place permanently or temporarily at a temperature below 37° C., optimally at a temperature of 33° C., the isolated Tregs are expanded in SCGM or X-vivo-20 medium supplemented with human serum or with foetal bovine serum, and magnetic beads coated with anti-CD3 and anti-CD28 antibodies at 1:1 (cell:bead) ratio and interleukin-2 are added to the culture.
    Type: Application
    Filed: July 21, 2021
    Publication date: November 11, 2021
    Inventors: Natalia MAREK-TRZONKOWSKA, Piotr TRZONKOWSKl, Malgorzata MYSLIWIEC
  • Method for ex vivo expansion of regulatory T cells
    Patent number: 11072779
    Abstract: The invention relates to a new method for in vitro expansion of CD4+CD25HighCD127?/LOWfoxP3+Tregs, wherein the process of Treg expansion takes place permanently or temporarily at a temperature below 37° C., optimally at a temperature of 33° C., the isolated Tregs are expanded in SCGM or X-vivo-20 medium supplemented with human serum or with foetal bovine serum, and magnetic beads coated with anti-CD3 and anti-CD28 antibodies at 1:1 (cell:bead) ratio and interleukin-2 are added to the culture.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: July 27, 2021
    Assignee: GDANSKI UNIWERSYTET MEDYCZNY
    Inventors: Natalia Marek-Trzonkowska, Piotr Trzonkowski, Malgorzata Mysliwiec
  • THERAPEUTIC VACCINE FOR TREATMENT OF DIABETES TYPE 1 IN CHILDREN, APPLICATION OF THE CELL SORTER AND THE METHOD OF MULTIPLYING TREG CELLS TO PRODUCE THERAPEUTIC VACCINE FOR TREATMENT OF DIABETES TYPE 1
    Publication number: 20200054724
    Abstract: The gist of the invention consists in the therapeutic vaccine for treatment of diabetes type 1 in children, which contains Treg cells CD3(+)CD4(+)CD25(high)CD127(?). Claimed too is the cell sorter used to produce the vaccine and the method of multiplying Treg cells in vitro.
    Type: Application
    Filed: October 23, 2019
    Publication date: February 20, 2020
    Inventors: Piotr Trzonkowski, Malgorzata Mysliwiec, Natalia Marek-Trzonkowska
  • METHOD FOR EX VIVO EXPANSION OF REGULATORY T CELLS
    Publication number: 20180362928
    Abstract: The invention relates to a new method for in vitro expansion of CD4+CD25HighCD127?/LOWfoxP3+Tregs, wherein the process of Treg expansion takes place permanently or temporarily at a temperature below 37° C., optimally at a temperature of 33° C., the isolated Tregs are expanded in SCGM or X-vivo-20 medium supplemented with human serum or with foetal bovine serum, and magnetic beads coated with anti-CD3 and anti-CD28 antibodies at 1:1 (cell:bead) ratio and interleukin-2 are added to the culture.
    Type: Application
    Filed: December 19, 2016
    Publication date: December 20, 2018
    Inventors: Natalia MAREK-TRZONKOWSKA, Piotr TRZONKOWSKl, Malgorzata MYSLIWIEC
  • THERAPEUTIC VACCINE FOR TREATMENT OF DIABETES TYPE 1 IN CHILDREN, APPLICATION OF THE CELL SORTER AND THE METHOD OF MULTIPLYING TREG CELLS TO PRODUCE THERAPEUTIC VACCINE FOR TREATMENT OF DIABETES TYPE 1
    Publication number: 20180117134
    Abstract: The gist of the invention consists in the therapeutic vaccine for treatment of diabetes type 1 in children, which contains Treg cells CD3(+)CD4(+)CD25(high)CD127(?). Claimed too is the cell sorter used to produce the vaccine and the method of multiplying Treg cells in vitro.
    Type: Application
    Filed: December 22, 2017
    Publication date: May 3, 2018
    Inventors: Piotr Trzonkowski, Malgorzata Mysliwiec, Natalia Marek-Trzonkowski
  • THERAPEUTIC VACCINE FOR TREATMENT OF DIABETES TYPE 1 IN CHILDREN, APPLICATION OF THE CELL SORTER AND THE METHOD OF MULTIPLYING TREG CELLS TO PRODUCE THERAPEUTIC VACCINE FOR TREATMENT OF DIABETES TYPE 1
    Publication number: 20150165007
    Abstract: The gist of the invention consists in the therapeutic vaccine for treatment of diabetes type 1 in children, which contains Treg cells CD3(+)CD4(+)CD25(high)CD127(?). Claimed too is the cell sorter used to produce the vaccine and the method of multiplying Treg cells in vitro.
    Type: Application
    Filed: June 4, 2013
    Publication date: June 18, 2015
    Applicant: Gdanski Uniwersytet Medyczny
    Inventors: Piotr Trzonkowski, Malgorzata Mysliwiec, Natalia Marek-Trzonkowski