Patents by Inventor Malika Gunasekera

Malika Gunasekera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sterol disulfates and methods of use
    Patent number: 5079239
    Abstract: Novel sterol disulfates have been isolated from the marine sponge Petrosia weinbergii. These compounds, and derivatives thereof, are useful antiviral compounds. One of these compounds is active against the AIDS virus and exhibits immunosuppressive activity.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: January 7, 1992
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: H. Howard Sun, Sue S. Cross, Frank Koehn, Malika Gunasekera
  • Novel bioactive discodermides and methods of use
    Patent number: 5059618
    Abstract: A novel lactam discodermide has been isolated from a marine sponge. This compound, and its derivatives, are useful as antifungal and antitumor agents.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: October 22, 1991
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Sarath P. Gunasekera, Malika Gunasekera, Peter J. McCarthy
  • Discodermolide compounds, compositions containing same and method of preparation and use
    Patent number: 5010099
    Abstract: Novel lactone compounds having remarkable immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to the formula: ##STR1## wherein: R=--H, --A, --CH.sub.2 --Q, --COA or --COZ,A=lower alkyl,Z=monocyclicaryl,Q=phenyl, tolyl or xylyl,X=--H, --A, --Z or --CH.sub.2 --Z, andY=--H, --A, --Z, --CH.sub.2 --Z, --COA, --COZ,the acid-addition salts, the octahydro and 23,24-dihydro derivatives thereof.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: April 23, 1991
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Malika Gunasekera, Sarath P. Gunasekera, Ross E. Longley, Neal S. Burres
  • Discodermolide compounds, compositions containing same and methods of preparation and use
    Patent number: 4939168
    Abstract: Novel lactone compounds having remarkable immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to the formula: ##STR1## wherein: R=--H, --A, --CH.sub.2 --Q, --COA or --COZ,A=lower alkyl,Z=monocyclicaryl,Q=phenyl, tolyl or xylyl,X=--H, --A, --Z or --CH.sub.2 --Z, andY=--H, --A, --Z, --CH.sub.2 --Z, --COA, --COZ,the acid-addition salts, the octahydro and 23,24-dihydro derivatives thereof.
    Type: Grant
    Filed: August 11, 1989
    Date of Patent: July 3, 1990
    Assignee: Harbor Branch Oceanographics Institution, Inc.
    Inventors: Malika Gunasekera, Sarath P. Gunasekera, Ross E. Longley, Neal S. Burres