Patents by Inventor Malken Bayrakdarian

Malken Bayrakdarian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modular synthesis of aminoglycosides
    Patent number: 11673907
    Abstract: The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: June 13, 2023
    Assignee: Revagenix, Inc.
    Inventors: Andrew Calabrese, Timothy Robert Kane, Darin Hildebrandt, Michael Lopez, Nikolai Evdokimov, Frederick Cohen, Malken Bayrakdarian, Sanjia Xu, Samuel Desjardins, Olivier Soueidan
  • MODULAR SYNTHESIS OF AMINOGLYCOSIDES
    Publication number: 20230167148
    Abstract: The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.
    Type: Application
    Filed: December 21, 2022
    Publication date: June 1, 2023
    Inventors: Andrew Antony Calabrese, Timothy Robert Kane, Darin Hildebrandt, Michael Lopez, Nikolai Evdokimov, Frederick Cohen, Malken Bayrakdarian, Sanijia Xu, Samuel Desjardins, Olivier Soueidan
  • SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20230120413
    Abstract: This application relates to substituted benzimidazoles, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted benzimidazoles and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Application
    Filed: May 13, 2022
    Publication date: April 20, 2023
    Inventors: Mehrnaz POURASHRAF, Guillaume JACQUEMOT, Stephen CLARIDGE, Malken BAYRAKDARIAN, Shawn JOHNSTONE, Jeffrey S. ALBERT, Andrew GRIFFIN
  • MODULAR SYNTHESIS OF AMINOGLYCOSIDES
    Publication number: 20220411456
    Abstract: The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.
    Type: Application
    Filed: August 24, 2018
    Publication date: December 29, 2022
    Applicant: Revagenix, Inc.
    Inventors: Andrew CALABRESE, Timothy Robort KANE, Darin HILDEBRANDT, Michael LOPEZ, Nikolai EVDOKIMOV, Frederick COHEN, Malken BAYRAKDARIAN, Sanijia XU, Samuel DESJARDINS, Olivier SOUEIDAN
  • Substituted benzimidazoles, their preparation and their use as pharmaceuticals
    Patent number: 11365186
    Abstract: This application relates to substituted benzimidazoles, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted benzimidazoles and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: June 21, 2022
    Assignee: EPIGENETIX, INC.
    Inventors: Mehrnaz Pourashraf, Guillaume Jacquemot, Stephen Claridge, Malken Bayrakdarian, Shawn Johnstone, Jeffrey S. Albert, Andrew Griffin
  • SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20210107893
    Abstract: This application relates to substituted benzimidazoles, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted benzimidazoles and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Application
    Filed: May 22, 2020
    Publication date: April 15, 2021
    Inventors: Mehrnaz POURASHRAF, Guillaume JACQUEMOT, Stephen CLARIDGE, Malken BAYRAKDARIAN, Shawn JOHNSTONE, Jeffrey S. ALBERT, Andrew GRIFFIN
  • N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
    Patent number: 10836742
    Abstract: This application relates to N-substituted bicyclic lactams of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to the N-substituted bicyclic lactams of formula (I) and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: November 17, 2020
    Assignee: Neomed Institute
    Inventors: Guillaume Jacquemot, Stephen Claridge, Malken Bayrakdarian, Shawn Johnstone, Jeffrey S. Albert, Andrew Griffin
  • ARYL-SUBSTITUTED DIHYDROQUINOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20200299262
    Abstract: This application relates to aryl-substituted dihydroquinolinones of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to aryl-substituted dihydroquinolinones and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Application
    Filed: October 28, 2019
    Publication date: September 24, 2020
    Inventors: Guillaume JACQUEMOT, Malken BAYRAKDARIAN, Shawn JOHNSTONE, Jeffrey S. ALBERT, Andrew GRIFFIN
  • SUBSTITUTED IMIDAZOPYRIDINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20200299291
    Abstract: This application relates to substituted imidazopyridines, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted imidazopyridines and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Application
    Filed: October 29, 2019
    Publication date: September 24, 2020
    Inventors: Mehrnaz POURASHRAF, Marc-Andre BEAULIEU, Stephen CLARIDGE, Malken BAYRAKDARIAN, Shawn JOHNSTONE, Jeffrey S. ALBERT, Andrew GRIFFIN
  • SUBSTITUTED [1,2,4]TRIAZOLO[4,3-A]PYRIDINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20200299292
    Abstract: This application relates to substituted [1,2,4]triazolo[4,3-a]pyridines of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted [1,2,4]triazolo[4,3-a]pyridines and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Application
    Filed: November 19, 2019
    Publication date: September 24, 2020
    Inventors: Malken BAYRAKDARIAN, Stephen CLARIDGE, Andrew GRIFFIN
  • Substituted benzimidazoles, their preparation and their use as pharmaceuticals
    Patent number: 10703740
    Abstract: This application relates to substituted benzimidazoles, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted benzimidazoles and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: July 7, 2020
    Assignee: Neomed Institute
    Inventors: Mehrnaz Pourashraf, Guillaume Jacquemot, Stephen Claridge, Malken Bayrakdarian, Shawn Johnstone, Jeffrey S. Albert, Andrew Griffin
  • N-SUBSTITUTED BICYCLIC LACTAMS, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20200024253
    Abstract: This application relates to N-substituted bicyclic lactams of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to the N-substituted bicyclic lactams of formula (I) and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Application
    Filed: August 11, 2016
    Publication date: January 23, 2020
    Inventors: Guillaume JACQUEMOT, Stephen CLARIDGE, Malken BAYRAKDARIAN, Shawn JOHNSTONE, Jeffrey S. ALBERT, Andrew GRIFFIN
  • Substituted [1,2,4]triazolo[4,3-A]pyridines, their preparation and their use as pharmaceuticals
    Patent number: 10519151
    Abstract: This application relates to substituted [1,2,4]triazolo[4,3-a]pyridines of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted [1,2,4]triazolo[4,3-a]pyridines and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: December 31, 2019
    Assignee: Neomed Institute
    Inventors: Malken Bayrakdarian, Stephen Claridge, Andrew Griffin
  • Substituted imidazo[1,2-a]pyridines as bromodomain inhibitors
    Patent number: 10501459
    Abstract: This application relates to substituted imidazopyridines, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted imidazopyridines of Formula I and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: December 10, 2019
    Assignee: Neomed Institute
    Inventors: Mehrnaz Pourashraf, Marc-Andre Beaulieu, Stephen Claridge, Malken Bayrakdarian, Shawn Johnstone, Jeffrey S. Albert, Andrew Griffin
  • Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals
    Patent number: 10501438
    Abstract: This application relates to aryl-substituted dihydroquinolinones of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to aryl-substituted dihydroquinolinones and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: December 10, 2019
    Assignee: Neomed Institute
    Inventors: Guillaume Jacquemot, Malken Bayrakdarian, Shawn Johnstone, Jeffrey S. Albert, Andrew Griffin
  • Rac inhibitors
    Patent number: 10472352
    Abstract: The present invention relates to compounds that act as pan-Rac inhibitors, compositions including the compounds, and methods of using the compounds. In particular, the compounds are useful for treating certain cancers such as breast cancer.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: November 12, 2019
    Assignee: GENEYUS LLC
    Inventors: Marc Lippman, Erik Goka, Shawn D. Johnstone, Malken Bayrakdarian, William Brown, Jeffrey S. Albert
  • RAC INHIBITORS
    Publication number: 20190031647
    Abstract: The present invention relates to compounds that act as pan-Rac inhibitors, compositions including the compounds, and methods of using the compounds. In particular, the compounds are useful for treating certain cancers such as breast cancer.
    Type: Application
    Filed: July 25, 2018
    Publication date: January 31, 2019
    Applicant: Geneyus LLC
    Inventors: Marc LIPPMAN, Erik GOKA, Shawn D. JOHNSTONE, Malken BAYRAKDARIAN, William BROWN, Jeffrey S. ALBERT
  • SUBSTITUTED [1,2,4]TRIAZOLO[4,3-A]PYRIDINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20190031657
    Abstract: This application relates to substituted [1,2,4]triazolo[4,3-a]pyridines of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted [1,2,4]triazolo[4,3-a]pyridines and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Application
    Filed: January 27, 2017
    Publication date: January 31, 2019
    Inventors: Malken BAYRAKDARIAN, Stephen CLARIDGE, Andrew GRIFFIN
  • SUBSTITUTED IMIDAZOPYRIDINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20180312504
    Abstract: This application relates to substituted imidazopyridines, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted imidazopyridines and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Application
    Filed: October 20, 2016
    Publication date: November 1, 2018
    Inventors: Mehrnaz POURASHRAF, Marc-Andre BEAULIEU, Stephen CLARIDGE, Malken BAYRAKDARIAN, Shawn JOHNSTONE, Jeffery S. ALBERT, Andrew GRIFFIN
  • SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20180237417
    Abstract: This application relates to substituted benzimidazoles, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted benzimidazoles and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
    Type: Application
    Filed: August 12, 2016
    Publication date: August 23, 2018
    Inventors: Mehrnaz POURASHRAF, Guillaume JACQUEMOT, Stephen CLARIDGE, Malken BAYRAKDARIAN, Shawn JOHNSTONE, Jeffrey S. ALBERT, Andrew GRIFFIN