Patents by Inventor Malle SCHMIDT

Malle SCHMIDT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
    Publication number: 20220023280
    Abstract: This invention provides a composition comprising pridopidine or pharmaceutically acceptable salt thereof and at least one of compounds 1-8: or a pharmaceutically acceptable salt thereof; and to methods of use thereof.
    Type: Application
    Filed: October 11, 2021
    Publication date: January 27, 2022
    Inventors: Malle SCHMIDT, Malle PARI, Marit LAOS, Ants MAASALU, Kalle KALJUSTE
  • Analogs of pridopidine, their preparation and use
    Patent number: 11141412
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof, processes for making the same and to compositions comprising pridopidine with these compounds.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: October 12, 2021
    Assignee: PRILENIA NEUROTHERAPEUTICS LTD.
    Inventors: Malle Schmidt, Malle Pari, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
    Publication number: 20200030308
    Abstract: This invention provides an isolated compound having the structure: or, or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 8, 2019
    Publication date: January 30, 2020
    Inventors: Malle SCHMIDT, Malle PARI, Marit LAOS, Ants MAASALU, Kalle KALJUSTE
  • Analogs of pridopidine, their preparation and use
    Patent number: 10406145
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: September 10, 2019
    Assignee: PRILENIA NEUROTHERAPEUTICS LTD.
    Inventors: Malle Schmidt, Malle Päri, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
    Publication number: 20190030016
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 3, 2018
    Publication date: January 31, 2019
    Applicant: Teva Pharmaceutical Industries Ltd.
    Inventors: Malle Schmidt, Malle Päri, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • Analogs of pridopidine, their preparation and use
    Patent number: 10130621
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridne, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: November 20, 2018
    Assignee: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Malle Schmidt, Malle Päri, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • Process for preparing lacosamide and related compounds
    Patent number: 9771317
    Abstract: There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: September 26, 2017
    Assignees: Cambrex Karlskoga AB, Cambrex Profarmaco Milano
    Inventors: Stefano Radaelli, Giuseppe Zurlo, Lars Eklund, Margus Eek, Ants Maasalu, Malle Schmidt
  • ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
    Publication number: 20150374677
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridne, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 29, 2015
    Publication date: December 31, 2015
    Applicant: Teva Pharmaceutical Industries Ltd.
    Inventors: Malle Schmidt, Malle Päri, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • NEW PROCESS
    Publication number: 20150299105
    Abstract: There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application.
    Type: Application
    Filed: November 1, 2013
    Publication date: October 22, 2015
    Inventors: Stefano RADAELLI, Giuseppe ZURLO, Lars EKLUND, Margus EEK, Ants MAASALU, Malle SCHMIDT