Patents by Inventor Malon Kit

Malon Kit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Infectious bovine rhinotracheitis virus insertion mutants, vaccines containing same, and methods for the production of same
    Patent number: 5601816
    Abstract: The present invention relates to infectious bovine rhinotracheitis viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against infectious bovine rhinotracheitis containing the same and methods for production and use of same. The present invention also relates to infectious bovine rhinotracheitis-based viral vectors useful for the coexpression of foreign genes.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: February 11, 1997
    Assignees: Novagene, Inc., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit
  • Equine herpesvirus 1 tk mutants
    Patent number: 5292653
    Abstract: The present invention relates to Equine Herpesvirus Type 1 mutants which fail to produce any functional thymidine kinase as a result of a deletion and/or insertion in the EHV-1 thymidine kinase gene.
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: March 8, 1994
    Assignees: NovaGene, Inc., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit
  • Infectious bovine rhinotrachetis virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
    Patent number: 5128129
    Abstract: Infectious bovine rhinotracheitis virus (bovine herpesvirus type 1) mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced, vaccines for infectious bovine rhinotracheitis containing the same, methods for the production of the same and methods for use of the same. Animals vaccinated with these mutants do not develop antibodies to the viral glycoprotein and can be distinguished serologically from animals infected with infectious bovine rhinotracheitis virus field strains.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: July 7, 1992
    Assignees: Novagene Inc., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit, Haruki Otsuka
  • Thymidine kinase negative insertion mutants of pseudorabies virus and methods for the production of same
    Patent number: 4999296
    Abstract: The present invention relates to pseudorabies viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against pseudorabies containing the same, and methods for the production and use of the same. The present invention also relates to pseudorabies virus based viral vectors for the coexpression of foreign genes.
    Type: Grant
    Filed: April 29, 1986
    Date of Patent: March 12, 1991
    Assignees: NovaGene, Inc., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit
  • Infectious bovine rhinotracheitis virus mutants, methods for the production of same and methods for the use of same
    Patent number: 4992051
    Abstract: Infectious bovine rhinotracheitis virus (bovine herpesvirus type 1) mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced, vaccines for infectious bovine rhinotrachetis containing the same, methods for the production of the same and methods for use of the same. Animals vaccinated with these mutants do not develop antibodies to the viral glycoprotein and can be distinguished serologically from animals infected with infectious bovine rhinotracheitis virus field strains.
    Type: Grant
    Filed: November 8, 1987
    Date of Patent: February 12, 1991
    Assignees: Novagene, Inc., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit, Haruki Otsuka
  • Thymidine kinase deletion mutants of bovine herpesvirus-1, vaccines against infectious bovine rhinotracheitis containing same and methods for the production and use of same
    Patent number: 4824667
    Abstract: Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: April 25, 1989
    Assignees: NovaGene, Inc., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit
  • Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
    Patent number: 4753884
    Abstract: The present invention relates to pseudorabies virus mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced. As a result, animals vaccinated with such do not develop antibodies to the viral glycoprotein and can be distinguished from animals infected with pseudorabies virus field strains and known pseudorabies virus vaccine strains. The present invention also relates to vaccines for pseudorabies disease containing the same, methods for production of the same and methods for use of the same.
    Type: Grant
    Filed: September 10, 1987
    Date of Patent: June 28, 1988
    Assignees: NovaGene, Inc., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit
  • Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
    Patent number: 4711850
    Abstract: The present invention relates to pseudorabies virus mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced. As a result, animals vaccinated with such do not develop antibodies to the viral glycoprotein and can be distinguished from animals infected with pseudorabies virus field strains and known pseudorabies virus vaccine strains. The present invention also relates to vaccines for pseudorabies disease containing the same, methods for production of the same and methods for use of the same.
    Type: Grant
    Filed: January 28, 1986
    Date of Patent: December 8, 1987
    Assignees: NovaGene, Inc., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit
  • Thymidine kinase deletion mutants of bovine herpesvirus-1
    Patent number: 4703011
    Abstract: Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: October 27, 1987
    Assignees: NovaGene, Inc., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit
  • Vaccines for pseudorabies disease and methods for use of same
    Patent number: 4609548
    Abstract: Temperature-resistant pseudorabies viruses which fail to produce any functional TK as a result of mutagen-induced mutation and temperature-resistant pseudorabies viruses which fail to produce any functional TK as a result of a deletion in the tk gene, vaccines containing same, methods for production of same and methods for use of same.
    Type: Grant
    Filed: December 20, 1984
    Date of Patent: September 2, 1986
    Assignees: Novagene, Ltd., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit
  • Modified live pseudorabies viruses
    Patent number: 4514497
    Abstract: Temperature-resistant pseudorabies viruses which fail to produce any functional TK as a result of mutagen-induced mutation and temperature-resistant pseudorabies viruses which fail to produce any functional TK as a result of a deletion in the tk gene, vaccines containing same, methods for production of same and methods for use of same.
    Type: Grant
    Filed: December 30, 1983
    Date of Patent: April 30, 1985
    Assignees: Novagene, Ltd., Baylor College of Medicine
    Inventors: Malon Kit, Saul Kit
  • Method for the quantitative determination of terminal deoxynucleotidyl transferase in biological samples
    Patent number: 4307189
    Abstract: Terminal Deoxynucleotidyl Transferase (TdT) may now be quantified in a biological sample without interference from other DNA polymerases normally found therein by utilizing labeled deoxynucleoside triphosphates and/or labeled single stranded oligodeoxynucleotides which have been chemically modified to impair or destroy their ability to form nucleotide base pairs by hydrogen bonding. Such modified deoxynucleoside triphosphates and/or oligodeoxynucleotides of impaired base forming abilities are selectively synthesized by TdT into fluorescently or radioactively labeled acid insoluble polydeoxynucleotides which may be quantified to determine the amount of TdT originally present in the biological sample.
    Type: Grant
    Filed: March 21, 1980
    Date of Patent: December 22, 1981
    Inventor: Malon Kit