Patents by Inventor Malthe Hansen-Bruhn

Malthe Hansen-Bruhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION AND QUANTIFICATION OF SMALL MOLECULES
    Publication number: 20220137034
    Abstract: The present invention relates to an in vitro method for determining the presence, absence and/or concentration of an analyte in a sample. The method uses an optically based competition assay comprising a labelled analyte binding protein and a labelled analyte analogue. The concentration/presence of the analyte is determined by inhibitory binding of the analyte to the analyte binding protein thereby impeding binding of the analyte analogue to the analyte binding protein. The invention further relates to kits, solid supports, cartridges, detection chips and uses thereof.
    Type: Application
    Filed: February 21, 2020
    Publication date: May 5, 2022
    Inventors: Kurt Vesterager Gothelf, Michael Rosholm Mortensen, Malthe Hansen-Bruhn, Line Debois Frejlev Nielsen, Jesper Vinther Sørensen
  • Nano/micromotors for active and dynamic intracellular payload delivery
    Patent number: 11007281
    Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: May 18, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNA
    Inventors: Joseph Wang, Berta Esteban-Fernández de Ávila, Yi Chen, Chava Angell, Fernando Soto, Liangfang Zhang, Malthe Hansen-Bruhn
  • NANO/MICROMOTORS FOR ACTIVE AND DYNAMIC INTRACELLULAR PAYLOAD DELIVERY
    Publication number: 20190070314
    Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.
    Type: Application
    Filed: March 28, 2018
    Publication date: March 7, 2019
    Inventors: Joseph Wang, Berta Esteban-Fernández de Ávila, Yi Chen, Chava Angell, Fernando Soto Alvarez, Liangfang Zhang, Malthe Hansen-Bruhn