Patents by Inventor Mamata Patel

Mamata Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functional fragments of HIV-1 VPR protein and methods of using the same
    Publication number: 20060088551
    Abstract: Conjugated compositions comprising a fragment of HIV-1 Vpr or a non-HIV-1 Vpr protein conjugated to a therapeutic compounds and methods of using the same to deliver therapeutic compounds to a cell's nucleus or for the preparation of drug delivery particles are disclosed. Functional fragments of HIV-1 Vpr and functional non-HIV-1 Vpr proteins, and pharmaceutical compositions comprising the same are disclosed. Methods of inhibiting cell proliferation and methods of treating an individual who has a hyperproliferative disease are disclosed. Methods of identifying compounds that inhibit Vpr protein binding to the p6 domain of p55 or to p6 protein and kits for performing such methods are disclosed.
    Type: Application
    Filed: September 29, 2004
    Publication date: April 27, 2006
    Inventors: Sundarasamy Mahalingam, Velpandi Ayyavoo, Mamata Patel, Thomas Kieber-Emmons, David Weiner
  • Cellular receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle
    Patent number: 6949337
    Abstract: The present invention provides methods of identifying anti-HIV compound by contacting human Vpr Interacting Protein (hVIP), or a fragment thereof known to interact with Vpr, with Vpr, or a fragment thereof known to interact with hVIP in the presence of a test compound, and comparing the affinity of the hVIP or fragment thereof to the Vpr or fragment thereof in the presence of the test compound with the affinity of the hVIP or fragment thereof to the Vpr or fragment thereof in the absence of the test compound. The present invention also provides transgenic non-human mammals comprising a recombinant expression vector that comprises a nucleic acid sequence that encodes hVIP.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: September 27, 2005
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Velpandi Ayyavoo, Sundarasamy Mahalingam, Mamata Patel
  • Functional fragments of HIV-1 Vpr protein and methods of using the same
    Patent number: 6818627
    Abstract: Conjugated compositions comprising a fragment of HIV-1 Vpr or a non-HIV-1 Vpr protein conjugated to a therapeutic compound and methods of using the same to deliver therapeutic compounds to a cell's nucleus or for the preparation of drug delivery particles are disclosed. Functional fragments of HIV-1 Vpr and functional non-HIV-1 Vpr proteins, and pharmaceutical compositions comprising the same are disclosed. Methods of inhibiting cell proliferation and methods of treating an individual who has a hyperproliferative disease are disclosed. Methods of identifying compounds that inhibit Vpr protein binding to the p6 domain of p55 or to p6 protein and kits for performing such methods are disclosed.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: November 16, 2004
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Sundarasamy Mahalingam, Velpandi Ayyavoo, Mamata Patel, Thomas Kieber-Emmons, David B. Weiner
  • Cellular receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle
    Publication number: 20030143735
    Abstract: The present invention provides methods of identifying an anti-HIV compound by contacting human Vpr Interacting Protein (hVIP), or a fragment thereof known to interact with Vpr, with Vpr, or a fragment thereof known to interact with hVIP in the presence of a test compound, and comparing the affinity of the hVIP or fragment thereof to the Vpr or fragment thereof in the presence of the test compound with the affinity of the hVIP or fragment thereof to the Vpr or fragment thereof in the absence of the test compound. The present invention also provides transgenic non-human mammals comprising a recombinant expression vector that comprises a nucleic acid sequence that encodes hVIP.
    Type: Application
    Filed: February 27, 2003
    Publication date: July 31, 2003
    Inventors: David B. Weiner, Velpandi Ayyavoo, Sundarasamy Mahalingam, Mamata Patel
  • Cellular receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle
    Patent number: 6448078
    Abstract: The present invention is directed to substantially pure Human Vpr Interacting Protein (hVIP), and fragments thereof.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: September 10, 2002
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Velpandi Ayyavoo, Sundarasamy Mahalingam, Mamata Patel
  • Cellular receptor for HIV-1 Vpr essential for G2/M phase
    Patent number: 6172201
    Abstract: The present invention is directed to substantially pure human Vpr Interacting Protein (hVIP), and fragments thereof.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: January 9, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Velpandi Ayyavoo, Sundarasamy Mahalingam, Mamata Patel
  • Cellular receptor for HIV-1 VPR essential for G2/M phase transition of the cell cycle
    Patent number: 6060587
    Abstract: The present invention is directed to substantially pure human Vpr Interacting Protein (hVIP), and fragments thereof.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: May 9, 2000
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Velpandi Ayyavoo, Sundarasamy Mahalingam, Mamata Patel