Patents by Inventor Mami MATANO

Mami MATANO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell culture medium for culturing organoid, culture method, and organoid
    Patent number: 11834681
    Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGH1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i (to III); i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGIF-?) inhibitor.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: December 5, 2023
    Assignee: KEIO UNIVERSITY
    Inventors: Toshiro Sato, Mami Matano
  • Cell culture medium for culturing organoid, culture method, and organoid
    Patent number: 11760978
    Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGH1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i (to III); i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGIF-?) inhibitor.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: September 19, 2023
    Assignee: KEIO UNIVERSITY
    Inventors: Toshiro Sato, Mami Matano
  • Cell culture medium for culturing organoid, culture method, and organoid
    Patent number: 11407980
    Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGF1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i) to iii): i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGF-?) inhibitor.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: August 9, 2022
    Assignee: KEIO UNIVERSITY
    Inventors: Toshiro Sato, Mami Matano
  • CELL CULTURE MEDIUM FOR CULTURING ORGANOID, CULTURE METHOD, AND ORGANOID
    Publication number: 20200231937
    Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGH1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i (to III); i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGIF-?) inhibitor.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 23, 2020
    Applicant: KEIO UNIVERSITY
    Inventors: Toshiro SATO, Mami MATANO
  • CELL CULTURE MEDIUM FOR CULTURING ORGANOID, CULTURE METHOD, AND ORGANOID
    Publication number: 20200216817
    Abstract: A cell culture medium for culturing organoid containing at lest two types of components selected from the group consisting of insulin-like growth factor 1 (IGH1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i (to III); i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGIF-?) inhibitor.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 9, 2020
    Applicant: KEIO UNIVERSITY
    Inventors: Toshiro SATO, Mami MATANO
  • CELL CULTURE MEDIUM FOR CULTURING ORGANOID, CULTURE METHOD, AND ORGANOID
    Publication number: 20190390171
    Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGF1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i) to iii): i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGF-?) inhibitor.
    Type: Application
    Filed: May 10, 2017
    Publication date: December 26, 2019
    Applicant: KEIO UNIVERSITY
    Inventors: Toshiro SATO, Mami MATANO
  • CELL CULTURE MEDIUM, CULTURE METHOD, AND ORGANOID
    Publication number: 20190100724
    Abstract: The present invention provides a cell culture medium with which serum-free long-term culture of an epithelial stem cell, an epithelial cancer cell, or a tissue containing at least one thereof can be achieved. The cell culture medium of the present invention includes: a Wnt agonist composed of a complex of Wnt protein and afamin, which is a substance capable of stabilizing the Wnt protein, and R-spondin; and at least one selected from the group consisting of a mitogenic growth factor, a bone morphogenetic protein (BMP) inhibitor, a transforming growth factor-? (TGF-?) inhibitor, and a p38 inhibitor.
    Type: Application
    Filed: February 17, 2017
    Publication date: April 4, 2019
    Inventors: Toshiro SATO, Mami MATANO, Shinya SUGIMOTO, Junichi TAKAGI