Patents by Inventor Mami TSUCHIYA
Mami TSUCHIYA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240135246Abstract: A data generation method for generating data for domain generalization in machine learning includes performing, with a computer, augmentation using training data as raw data usable to train a machine learning model, and extracting, with the computer, a dataset including the raw data and data generated through the augmentation as a dataset for the domain generalization.Type: ApplicationFiled: January 18, 2022Publication date: April 25, 2024Inventors: Mami Miyamoto, Seitaro Mura, Yuki Hirohashi, Atsushi Hashimoto, Takahiro Toku, Naoki Tsuchiya, Yoshihisa Ijiri, Yamato Okamoto
-
Patent number: 10494437Abstract: According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising CL-Fc prepared by fusion of an immunoglobulin light chain constant region (CL) and Fc region, and also has a deletion or substitution of Cys residues involved in disulfide bonds between CL and CH1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a DNA and a vector encoding the protein composition thereof are provided.Type: GrantFiled: June 15, 2017Date of Patent: December 3, 2019Assignee: KYOWA KIRIN CO., LTDInventors: Rinpei Niwa, Mami Tsuchiya, Takuya Murakami, Yuta Tezuka
-
Patent number: 10040861Abstract: Among N-glycoside-linked sugar chains which are bound to the Fc region of an antibody, sugar chains which are bound to Asn at position 297 relates to the activity and stability of the antibody in blood, but there is a possibility that extra sugar chains bound to the amino acid residues at positions other than 297 have influences upon the antibody constant region-mediated activity and a possibility of causing a problem of uniformity as a therapeutic antibody preparation. Accordingly, among N-glycoside-linked sugar chains which bind to the Fc region of the antibody, a method for controlling extra sugar chains which are bound to Asn residues at positions other than position 297 according to the EU index is required.Type: GrantFiled: December 16, 2016Date of Patent: August 7, 2018Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Rinpei Niwa, Mami Tsuchiya
-
Publication number: 20170362323Abstract: According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising CL-Fc prepared by fusion of an immunoglobulin light chain constant region (CL) and Fc region, and also has a deletion or substitution of Cys residues involved in disulfide bonds between CL and CH1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a DNA and a vector encoding the protein composition thereof are providedType: ApplicationFiled: June 15, 2017Publication date: December 21, 2017Applicant: KYOWA HAKKO KIRIN CO., LTDInventors: Rinpei NIWA, Mami TSUCHIYA, Takuya MURAKAMI, Yuta TEZUKA
-
Patent number: 9714291Abstract: According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising CL-Fc prepared by fusion of an immunoglobulin light chain constant region (CL) and Fc region, and also has a deletion or substitution of Cys residues involved in disulfide bonds between CL and CH1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a DNA and a vector encoding the protein composition thereof are provided.Type: GrantFiled: October 4, 2013Date of Patent: July 25, 2017Assignee: KYOWA HAKKO KIRIN CO., LTDInventors: Rinpei Niwa, Mami Tsuchiya, Takuya Murakami, Yuta Tezuka
-
Publication number: 20170190781Abstract: According to the present invention, anti-death receptor 3 (DR3) antagonistic IgG antibodies and antibody fragments thereof, wherein the antibodies and the antibody fragments thereof display a decreased agonistic activity or no agonistic activity for DR3 through their binding, an antibody compositions and an antibody fragment compositions comprising them, a nucleotide sequence encoding the antibody or the antibody fragment, a vector comprising the nucleotide sequences, an amino acid sequences of the antibodies or the antibody fragments, a method of producing the antibodies or the antibody fragments thereof, and a method of decreasing the agonistic potency of an antibody against DR3 through its binding, are provided.Type: ApplicationFiled: October 8, 2015Publication date: July 6, 2017Applicant: KYOWA HAKKO KIRIN CO., LTDInventors: David MILLS, Kazuma TOMIZUKA, John LAUDENSLAGER, Rinpei NIWA, Mami TSUCHIYA
-
Publication number: 20170166650Abstract: Among N-glycoside-linked sugar chains which are bound to the Fc region of an antibody, sugar chains which are bound to Asn at position 297 relates to the activity and stability of the antibody in blood, but there is a possibility that extra sugar chains bound to the amino acid residues at positions other than 297 have influences upon the antibody constant region-mediated activity and a possibility of causing a problem of uniformity as a therapeutic antibody preparation. Accordingly, among N-glycoside-linked sugar chains which bind to the Fc region of the antibody, a method for controlling extra sugar chains which are bound to Asn residues at positions other than position 297 according to the EU index is required.Type: ApplicationFiled: December 16, 2016Publication date: June 15, 2017Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Rinpei NIWA, Mami TSUCHIYA
-
Patent number: 9556279Abstract: Among N-glycoside-linked sugar chains which are bound to the Fc region of an antibody, sugar chains which are bound to Asn at position 297 relates to the activity and stability of the antibody in blood, but there is a possibility that extra sugar chains bound to the amino acid residues at positions other than 297 have influences upon the antibody constant region-mediated activity and a possibility of causing a problem of uniformity as a therapeutic antibody preparation. Accordingly, among N-glycoside-linked sugar chains which bind to the Fc region of the antibody, a method for controlling extra sugar chains which are bound to Asn residues at positions other than position 297 according to the EU index is required.Type: GrantFiled: March 2, 2011Date of Patent: January 31, 2017Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Rinpei Niwa, Mami Tsuchiya
-
Publication number: 20140120581Abstract: According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising CL-Fc prepared by fusion of an immunoglobulin light chain constant region (CL) and Fc region, and also has a deletion or substitution of Cys residues involved in disulfide bonds between CL and CH1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a DNA and a vector encoding the protein composition thereof are providedType: ApplicationFiled: October 4, 2013Publication date: May 1, 2014Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Rinpei NIWA, Mami TSUCHIYA, Takuya MURAKAMI, Yuta TEZUKA
-
Publication number: 20120010387Abstract: Among N-glycoside-linked sugar chains which are bound to the Fc region of an antibody, sugar chains which are bound to Asn at position 297 relates to the activity and stability of the antibody in blood, but there is a possibility that extra sugar chains bound to the amino acid residues at positions other than 297 have influences upon the antibody constant region-mediated activity and a possibility of causing a problem of uniformity as a therapeutic antibody preparation. Accordingly, among N-glycoside-linked sugar chains which bind to the Fc region of the antibody, a method for controlling extra sugar chains which are bound to Asn residues at positions other than position 297 according to the EU index is required.Type: ApplicationFiled: March 2, 2011Publication date: January 12, 2012Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Rinpei NIWA, Mami TSUCHIYA