Patents by Inventor Mamiko NINOMIYA

Mamiko NINOMIYA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREPARING INTERLEUKIN-2 OR INTERLEUKIN-2 ANALOGUES
    Publication number: 20210155665
    Abstract: A method for preparing interleukin-2 or an interleukin-2 analogue formed by at least three building blocks includes: synthesizing the at least three building blocks, whereby for each building block the C-terminal residue comprises an ?-keto group and/or the N-terminal residue comprises a cyclic hydroxylamine; coupling the at least three building blocks by KAHA ligation resulting in a depsipeptide; and rearranging the depsipeptide to obtain interleukin-2 or an interleukin-2 analogue.
    Type: Application
    Filed: January 29, 2021
    Publication date: May 27, 2021
    Applicant: ETH ZURICH
    Inventors: Jeffrey BODE, Claudia MURAR, Mamiko NINOMIYA
  • METHOD FOR PREPARING INTERLEUKIN-2 OR INTERLEUKIN-2 ANALOGUES
    Publication number: 20190023760
    Abstract: A method for preparing interleukin-2 or an interleukin-2 analogue formed by at least three building blocks including the steps of: a) Synthesizing the at least three building blocks, whereby the C-terminal amino acid of each building block is linked to an a-keto group and the N-terminal amino acid of each building block is linked to a cyclic hydroxylamine, b) Coupling the at least three building blocks by KAHA ligation resulting in a depsipeptide, c) Rearrangement of the depsipeptide to obtain interleukin-2 or an interleukin-2 analogue.
    Type: Application
    Filed: January 24, 2018
    Publication date: January 24, 2019
    Applicant: ETH ZURICH
    Inventors: Jeffrey BODE, Claudia MURAR, Mamiko NINOMIYA